A5057213706- Veterinary Oncology Research
- Virus-based gene therapy research
- Skin and Cellular Biology Research
- Cancer-related Molecular Pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Platelet Disorders and Treatments
- Lysosomal Storage Disorders Research
- Complement system in diseases
- Mast cells and histamine
- Veterinary Medicine and Surgery
- Microbial infections and disease research
- Congenital Ear and Nasal Anomalies
- Cell Adhesion Molecules Research
- Blood groups and transfusion
- Bone Tumor Diagnosis and Treatments
- Animal health and immunology
- Retinal Development and Disorders
- Retinoids in leukemia and cellular processes
- Teratomas and Epidermoid Cysts
- Venous Thromboembolism Diagnosis and Management
- Veterinary Equine Medical Research
- Telomeres, Telomerase, and Senescence
- Immunotoxicology and immune responses
- Vector-Borne Animal Diseases
- Trypanosoma species research and implications
Covance (United Kingdom)
2020
Queen's Hospital
2018-2019
University of Cambridge
2018-2019
Background Chronic hepatitis (CH) occurs commonly in dogs but is associated with a variable and largely unpredictable prognosis. p21, cell‐cycle inhibitor marker of cellular senescence, upregulated human liver disease better prognostic than histological or clinical scoring systems. Objective To quantify hepatocyte p21 immunopositivity histopathology samples from CH determine its association outcome. Animals Twenty‐six client‐owned histologically confirmed CH, 15 normal histology. Methods...
The incidence and range of spontaneous microscopic lesions were determined in the eyes male female control Sprague-Dawley Han Wistar rats. Data collected retrospectively from 1411, 817, 970, 658, 3999 rats groups 4-, 13-, 26-, 52-, 104-week studies, respectively, carried out between 1997 2019. Microscopic eye rare 4- 13-week uncommon 26- 52-week relatively higher studies. Neoplastic sporadic only observed In rats, most common (>1% studies) retinal degeneration, rosettes/folds, lenticular...
Nodular fat necrosis is a rare condition in the cat, and no cases of free‐floating abdominal masses cats have been previously reported literature. Furthermore, nodular when present has not associated with an acute abdomen presentation. An adult neutered female cat presented abdomen. exploratory laparotomy was performed identifying two within cavity patient. These were removed patient made uneventful recovery. The histopathological analysis consistent diagnosis necrosis. Acute presentation...
Abstract A 7‐year‐old, female, spayed springer spaniel presented due to acute stranguria and absence of reported urination by the owner. Two weeks earlier, it had been diagnosed with primary immune‐mediated thrombocytopenia for which was receiving prednisolone. Imaging revealed presence abdominal effusion severe urinary bladder changes, compatible cystitis wall haemorrhage. rupture at its cranioventral pole confirmed contrast study. Cytology fluid concluded septic uroabdomen. Surgical...
Abstract A 5‐year‐old, smooth‐haired miniature dachshund exhibited a progressive history of frequent episodes aggression towards objects, head pressing, circling and intermittent pelvic limb ataxia over period 2 weeks. Visual impairment was also noticed several months prior. Neurolocalisation consistent with forebrain disease. Blood urine analysis, magnetic resonance imaging the brain cerebrospinal fluid analysis were all unremarkable. The patient euthanased due to disease progression,...
A 1‐year, 8‐month‐old Rhodesian Ridgeback was presented with obtundation, ambulatory tetraparesis, and myoclonus. Initial clinical findings included ionized hypercalcemia an apparent marked increase in parathyroid hormone, thrombocytopenia, nonregenerative anemia. Low numbers of circulating atypical cells were noted on blood film evaluation. Brain magnetic resonance imaging identified extra‐axial contrast enhancing subtentorial lesion, cerebrospinal fluid (CSF) analysis documented a...
HistoryAn approximately 18-month-old Beltex ram was found dead in the field which it kept. The had a previous clinical history of breathing problem, but no details regarding examination or treatment were provided at time submission carcass.The underwent postmortem Department Veterinary Medicine, University Cambridge, UK. Tissue samples from all major organs fixed neutral-buffered 10% formalin solution, and histological sections prepared following standard protocols.Clinical Gross...