A5085679310- Immunotoxicology and immune responses
- Animal testing and alternatives
- Carcinogens and Genotoxicity Assessment
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sperm and Testicular Function
- Veterinary Pharmacology and Anesthesia
- Inhalation and Respiratory Drug Delivery
- Indoor Air Quality and Microbial Exposure
- Reproductive Biology and Fertility
- Veterinary Oncology Research
- Biochemical effects in animals
- Medicinal Plant Pharmacodynamics Research
- Viral Infectious Diseases and Gene Expression in Insects
- Liver Disease Diagnosis and Treatment
- Rabbits: Nutrition, Reproduction, Health
- Bladder and Urothelial Cancer Treatments
- Cardiac Fibrosis and Remodeling
- Diet and metabolism studies
- Helminth infection and control
- Dupuytren's Contracture and Treatments
- Diabetes Management and Research
- Urologic and reproductive health conditions
- Cell Image Analysis Techniques
Envigo (United Kingdom)
2019-2021
Covance (United Kingdom)
2019-2020
Liverpool Women's Hospital
2019
University of Liverpool
2019
Huntingdon College
2011-2014
Abstract This study details the breed, gender and neutering status of a large cohort British canine patients suffering from histologically confirmed anal sac gland carcinoma. Estimates relative risk for development this disease attributable to these factors are calculated. To reduce impact sampling errors, cases were selected veterinary histopathology laboratories rather than referral hospital databases, multiple estimates general population used. The weaknesses statistical assumptions made...
It is sometimes difficult to assess the relevance of tumors that occur in treated animals short-term studies. This report intended establish a general profile tumor occurrence young Han Wistar rats. Data were collected and evaluated from 29 rat carcinogenicity studies few 2-, 4-, 13-, 26-week conducted between 1995 2009 at Huntingdon Life Sciences, UK. The route administration was dietary, oral gavage, or inhalation, analysis confined sporadic deaths (decedents) In rats, most common earliest...
Many variables may affect the outcome of continuous infusion studies. The results largely depend on experience laboratory performing these studies, technical equipment used, choice blood vessels and hence surgical technique as well quality pathological evaluation. latter is major interest due to fact that pathologist not involved until necropsy in most cases, i.e. dealing with complicated or in-life procedures this study type. tissue sampling during histology processing influence tissues...
The evaluation of inhalation studies in monkeys is often hampered by the scarcity published information on relevant nasal anatomy and pathology. We examined cavities 114 control cynomolgus from 11 evaluated 2008 to 2013, order characterize document anatomic features spontaneous Compared other laboratory animals, monkey has a relatively simple nose with 2 unbranched, dorsoventrally stacked turbinates, large maxillary sinuses, septum that continues into nasopharynx. vomeronasal organ absent,...
Mowat, V., Turton, J., Stewart, Lui, K. C., and Pilling, A. M. (2009). Histopathological Features of Capillaria hepatica Infection in Laboratory Rabbits. Toxicol Pathol37, 661-666. DOI: 10.1177/0192623309339501. The above manuscript has been retracted from publication. following reason was stated: paper described the pathology associated with what thought to be a nematode parasite, hepatica. figures that appear show another Eimeria spp do not nematode. While some hepatic might have...
The Sprague Dawley (SD) and Han Wistar (HW) are the two most commonly used rat strains in Europe US, with increasing popularity because of its greater longevity lower tumor burden. This survey was undertaken at Covance CRS (Huntingdon Eye) to compare in-house common spontaneous profiles published data. Data were compiled from 104-week studies started between 2010 2017. Mean survival for both sexes HWs when compared SDs. Pituitary tumors commonest strains, slightly higher incidences more...
Summary Disorders of genital development occur in all mammals. Hermaphroditism is a condition where the subject has organs both sexes. True hermaphrodites have ovarian and testicular tissue. Pseudohermaphrodites only one type gonadal tissue according to which they are classified as male or female pseudohermaphrodites. Two cases spontaneously occurring pseudohermaphroditism Cynomolgus monkeys ( Macaca fascicularis ) were seen here during 1999–2001. Both animals had external genitalia, but...
This review was performed to assess the nature and incidence of procedure-related background changes in control dogs receiving saline by continuous infusion, compare them with data from a similar previously done Cynomolgus monkeys. Data were collected 14 dog studies over an 8-year period (i.e., 86 animals total). The restricted lesions at injection site, lungs catheter's entry point. most frequently seen endothelial hyperplasia (67.4%) intimal thickening site (80.2%) interstitial pneumonitis...
The incidence and range of spontaneous microscopic lesions were determined in the eyes male female control Sprague-Dawley Han Wistar rats. Data collected retrospectively from 1411, 817, 970, 658, 3999 rats groups 4-, 13-, 26-, 52-, 104-week studies, respectively, carried out between 1997 2019. Microscopic eye rare 4- 13-week uncommon 26- 52-week relatively higher studies. Neoplastic sporadic only observed In rats, most common (>1% studies) retinal degeneration, rosettes/folds, lenticular...
In this opinion piece, we discuss some proposed principles for designating adversity and nonadversity of histopathological changes. The suggested approach categorizes the classes findings noted in toxicity studies with illustrations examples suggests or each class, authors' opinions, rationales. Although suggestions offered piece are generally agreement Society Toxicologic Pathology best practices guideline on adversity, authors suggest highlight occasional divergences differences opinion....
The inter-laboratory performance of Isolated Chicken Eye (ICE) histopathology scoring was assessed for predicting EU CLP/UN GHS Cat. 1 surfactants. Furthermore, the predictive capacity ICE evaluated combined dataset surfactants and existing data non-extreme pH (2 < 11.5) detergents. Use led to increased sensitivity compared test method alone When with detergents, use in addition standard decreased false negative rates from 64% (14/22) 27% (6/22); accuracy 53% (16/30) 77% (23/30); acceptable...
A retrospective study was performed to establish the causes of mortality and incidence patterns tumors in young (<50 weeks) control CD-1® mice from Charles River Laboratories. Tumor incidences (fatal nonfatal) nonneoplastic death observed during first 50 weeks were collected 48 thirteen-week toxicity studies conducted between 2009 2018 43 carcinogenicity 2005 2018. Thirteen-week had a rate 8/620 (1.3%) males 4/620 (0.65%) females. The major factors contributing integument lesions (3/8)...