A5060826659- Lysosomal Storage Disorders Research
- Virus-based gene therapy research
- Neurogenesis and neuroplasticity mechanisms
- Cellular transport and secretion
- Glycosylation and Glycoproteins Research
- Nerve injury and regeneration
- Virology and Viral Diseases
- Multiple Sclerosis Research Studies
- Mast cells and histamine
- Animal testing and alternatives
- Growth Hormone and Insulin-like Growth Factors
- Viral Infections and Vectors
- Asthma and respiratory diseases
- Single-cell and spatial transcriptomics
- Immunotoxicology and immune responses
- Molecular Biology Techniques and Applications
- Oral and Maxillofacial Pathology
- Skin and Cellular Biology Research
- Gene expression and cancer classification
- Erythrocyte Function and Pathophysiology
- Animal Disease Management and Epidemiology
- Skin Protection and Aging
- Neuroscience of respiration and sleep
- Periodontal Regeneration and Treatments
- Genetically Modified Organisms Research
Psychiatry Baselland
2021-2025
Novartis (Switzerland)
2016-2023
Novartis Institutes for BioMedical Research
2016
University of Veterinary Medicine Hannover, Foundation
2005-2013
University of Veterinary Medicine
2012
University of Veterinary Medicine Vienna
2005-2008
Youngstown State University
1991
Abstract Melanocytes of the hair follicle produce melanin and are essential in determining differences color. Pigment cell-specific MELanocyte Protein (PMEL17) plays a crucial role melanogenesis. One critical steps is amyloid-like functional oligomerization PMEL17. Beta Site APP Cleaving Enzyme-2 (BACE2) γ-secretase have been shown to be key players generating proteolytic fragments The β-secretase (BACE1) responsible for generation amyloid-β (Aβ) brain therefore proposed as therapeutic...
SUMMARY Recurrence of peste des petits ruminants (PPR) was diagnosed in the United Arabian Emirates several wild confirmed by morphological, immunohistochemical, serological and molecular findings. Phylogenetic analysis revealed that virus strain belongs to lineage IV, which is different some previously isolated PPR strains from Peninsula. This study shows may play an important epidemiological role as source for domestic small ruminants.
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease characterized by myelin axonal pathology. In a viral model of MS, we tested whether axonopathy initiation development are based on impaired transport neurofilaments. Spinal cords Theiler's murine encephalomyelitis virus (TMEV)-infected mock-infected mice TMEV infected neuroblastoma N1E-115 cells were analyzed microarray analysis, light microscopy electron laser confocal microscopy. vivo accumulation non-phosphorylated...
Background Succinate, in addition to its role as an intermediary of the citric acid cycle, acts alarmin, initiating and propagating danger signals resulting from tissue injury or inflammatory stimuli. The contribution this immune sensing pathway development allergic responses is unknown. Methods Ear thickness wild-type (wt) Sucnr1-deficient (Sucnr1−/−) mice, sensitized challenged with oxazolone, was used a criterion assess relevance SUCNR1/GPR91 expression mediating contact dermatitis (ACD)....
Introduction Death initiates a cascade of physiological and biochemical alterations in organs tissues, resulting microscopic changes that challenge the histopathological evaluation. The aim this study was to compile illustrate kidneys rats subjected delayed postmortem fixation. It also scrutinizes influence exsanguination, cooling methods air circulation on initiation progression these alterations. Methods Twenty-four Wistar Han outbred (RccHan TM :WIST) were sacrificed stored either at room...
<b><i>Objectives:</i></b> Theiler’s murine encephalomyelitis virus (TMEV) infection of mice is a widely used animal model for demyelinating disorders, such as multiple sclerosis (MS). The aim the present study was to identify topographical differences TMEV spread and demyelination in brain experimentally infected susceptible SJL/J resistant C57BL/6 mice. <b><i>Methods:</i></b> Demyelination confirmed by Luxol fast blue cresyl violet staining...
Cementoma is a very rare odontogenic neoplasm of mesenchymal origin. Clinically, in 3 horses, multiple bony enlargements the upper and lower jaw extending into oral cavity were observed. Radiographically, multiple, well-circumscribed, radiopaque masses surrounding roots incisors or an premolar tooth present. Due to malocclusion local pain, single teeth extracted each case. Grossly, hard grayish-white mass root premolars was identified. Histopathologically, tumors consisted excessive...
Currently, several immunotherapies and BACE (Beta Site APP Cleaving Enzyme) inhibitor approaches are being tested in the clinic for treatment of Alzheimer's disease. A crucial mechanism-related safety concern is exacerbation microhemorrhages, which already present majority Alzheimer patients. To investigate potential liabilities long-term therapy, we used aged amyloid precursor protein (APP) transgenic mice (APP23), robustly develop cerebral angiopathy. T2*-weighted magnetic resonance...
Abstract A limited understanding of the pathology underlying chronic wounds has hindered development effective diagnostic markers and pharmaceutical interventions. This study aimed to elucidate molecular composition various common ulcer types facilitate drug discovery strategies. We conducted a comprehensive analysis leg ulcers (LUs), encompassing venous arterial ulcers, foot (FUs), pressure (PUs), compared them with surgical wound healing complications (WHCs). To explore pathophysiological...
GM(1)-gangliosidosis is a lysosomal storage disease that inherited as an autosomal recessive disorder, predominantly caused by structural defects in the beta-galactosidase gene (GLB1). The molecular cause of Alaskan huskies was investigated and novel 19-bp duplication exon 15 GLB1 identified. comprised positions +1688-+1706 cDNA. It partially disrupted potential splicing enhancer (ESE), leading to skipping fraction transcripts. Thus, mutation expression two different mRNAs from mutant...
Abstract G M1 ‐gangliosidosis is a lysosomal storage disorder caused by deficiency of ß‐galactosidase activity. Human GM1‐gangliosidosis has been classified into three forms according to the age clinical onset and specific biochemical parameters. In present study, canine model for type II late infantile human was investigated ‘ in vitro ’ detail. For better understanding molecular pathogenesis underlying study focused on analysis events subsequent intracellular protein trafficking...
Background Intra- and inter-species transmission of Human herpesvirus type 1 were noticed. In the present study, herpesviral infection a 1-year-old Azara’s Night Monkey (Aotus azarae) was investigated. Methods Immunohistochemistry electron microscopy investigations done. Results A fatal systemic demonstrated. Conclusion The results reveal susceptibility to 1. Moreover, humans shedding herpes viral particles during reactivation phase directly infect Monkeys.
Zusammenfassung: Gegenstand und Ziel: Die GM1-Gangliosidose der Alaskan Huskies ist eine angeborene Erkrankung, die durch einen autosomal rezessiv vererbten Defekt des Gens für saure β-Galaktosidase (GLB1) hervorgerufen wird. Klinisch zeigen Tiere Minderwuchs sowie, beginnend im Alter von sechs bis acht Wochen, neurologische Ausfallerscheinungen wie Ataxie Dysmetrie. Zur gezielten Vermeidung dieser Erkrankung es Zuchtentscheidungen wichtig, Anlageträger den sicher identifizieren zu können....
The inter-laboratory performance of Isolated Chicken Eye (ICE) histopathology scoring was assessed for predicting EU CLP/UN GHS Cat. 1 surfactants. Furthermore, the predictive capacity ICE evaluated combined dataset surfactants and existing data non-extreme pH (2 < 11.5) detergents. Use led to increased sensitivity compared test method alone When with detergents, use in addition standard decreased false negative rates from 64% (14/22) 27% (6/22); accuracy 53% (16/30) 77% (23/30); acceptable...
Bisphenol A (BPA), an endocrine-disrupting chemical and environmental pollutant, has been reported by many researchers to induce male reproductive toxicity in different experimental models. In this study, we investigated whether long-term exposure for two months 25 µg/kg body weight (low dose) of BPA affects spermatogenesis or sperm quality young Istrian Pramenka rams exposed via diet. We evaluated testicular weights, histopathology testes epididymides, analyses, compared these parameters...