A5005566088- Infectious Diseases and Mycology
- Veterinary Oncology Research
- Laser Applications in Dentistry and Medicine
- Solid State Laser Technologies
- Laser Material Processing Techniques
- Retinoids in leukemia and cellular processes
- Thyroid Disorders and Treatments
- AI in cancer detection
- Microtubule and mitosis dynamics
- Cell Adhesion Molecules Research
- Oral and Maxillofacial Pathology
- Parasitic infections in humans and animals
- Fibroblast Growth Factor Research
- Sphingolipid Metabolism and Signaling
- Vascular Tumors and Angiosarcomas
- Hair Growth and Disorders
- Protein purification and stability
- Neurogenetic and Muscular Disorders Research
- Research on Leishmaniasis Studies
- Radiomics and Machine Learning in Medical Imaging
- Oropharyngeal Anatomy and Pathologies
- Antioxidant Activity and Oxidative Stress
- Tendon Structure and Treatment
- T-cell and B-cell Immunology
- Advanced Drug Delivery Systems
IDEXX Laboratories (Germany)
2021-2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2022
Freie Universität Berlin
2022
University of Bern
2003-2022
University of Veterinary Medicine Vienna
2022
North Carolina State University
2022
Technische Hochschule Ingolstadt
2022
Roche (Switzerland)
2022
Ludwig-Maximilians-Universität München
2022
Michigan State University
2022
Aberrant signaling by transforming growth factor-β (TGF-β) and its type I (ALK5) receptor has been implicated in a number of human diseases this pathway is considered potential target for therapeutic intervention. Transforming via ALK5 plays critical role during heart development, but the adult poorly understood. In current study, preclinical toxicology inhibitors from two different chemistry scaffolds was explored. Ten-week-old female Han Wistar rats received test compounds oral route three...
The Ras/RAF/MEK/ERK pathway is frequently deregulated in cancer and a number of inhibitors that target this are currently clinical development. It likely testing these agents will be combination with standard therapies to harness the apoptotic potential both agents. To support strategy, it has been widely observed chemotherapeutics stimulate activation several intracellular signalling cascades including Ras/RAF/MEK/ERK. MEK1/2 inhibitor selumetinib shown have anti-tumour activity induce cell...
Abstract Melanocytes of the hair follicle produce melanin and are essential in determining differences color. Pigment cell-specific MELanocyte Protein (PMEL17) plays a crucial role melanogenesis. One critical steps is amyloid-like functional oligomerization PMEL17. Beta Site APP Cleaving Enzyme-2 (BACE2) γ-secretase have been shown to be key players generating proteolytic fragments The β-secretase (BACE1) responsible for generation amyloid-β (Aβ) brain therefore proposed as therapeutic...
Two cats with Leishmania species infections were investigated. The first had been imported from Spain a non‐healing, ulcerated nodule on hindleg. presence of was detected by histopathology and PCR samples skin. lesion unresponsive to treatment allopurinol for three months but the cat treated successfully removing surgically. second lived in both Switzerland, history recurrent skin lesions its head neck. A diagnosis pemphigus foliaceus made basis histopathology, serology ( ELISA ) positive,...
The mitotic count (MC) is an important histological parameter for prognostication of malignant neoplasms. However, it has inter- and intraobserver discrepancies due to difficulties in selecting the region interest (MC-ROI) identifying or classifying figures (MFs). Recent progress field artificial intelligence allowed development high-performance algorithms that may improve standardization MC. As algorithmic predictions are not flawless, computer-assisted review by pathologists ensure...
We have previously shown that activation of Gαi2, an α subunit the heterotrimeric G protein complex, induces skeletal muscle hypertrophy and myoblast differentiation. To determine whether Gαi2 is required for growth or regeneration, Gαi2-null mice were analyzed. knockout display decreased lean body mass, reduced size, impaired regeneration after cardiotoxin-induced injury. Short hairpin RNA (shRNA)-mediated knockdown in satellite cells (SCs) leads to defective cell proliferation, fusion,...
Drug-induced kidney injury (DIKI) results in attrition during drug development; new DIKI urinary biomarkers offer potential to detect and monitor progression regression, but frequently only rats. The triple reuptake inhibitor (TRI) PRC200-SS represents a class of antidepressants that elevate synaptic levels serotonin, norepinephrine, dopamine is expected produce more rapid onset better antidepressant efficacy than single or dual inhibitors. Although preclinical studies recent clinical trials...
High-power laser therapy gained popularity recently as a regenerative treatment for tendinitis and desmitis in the horse. However, studies evaluating effects of on tissue repair at histological level large mammals are lacking.To evaluate high-power suspensory healing, using model ligament branch injury.In vivo experiments.Standardised lesions were surgically induced all four lateral branches 12 healthy Warmblood horses. Laser (class 4, 15W) was applied daily two consecutive weeks. Horses...
A 2-years old male Labrador retriever dog was presented with intermittent therapy-resistant diarrhoea, accompanied by vomiting, inappetence, apathy, and mild fever. The blood analysis showed an anaemia, neutrophilia, eosinophilia, increased liver enzymes. Abdominal palpation slightly painful. X-rays echography revealed a severely enlarged multiple cavernous structures. Histopathologic examination of biopsies severe chronic granulomatous hepatitis numerous parasitic cysts. Morphology the...
Histological examination of the heart a clinically normal, 10-week-old female Han Wistar rat revealed 600 x 400-mum mass ectopic thyroid tissue within subendothelial connective aortic valve. The protruded into left ventricular lumen and was composed single layers cuboidal to low-columnar epithelium organized follicles often containing colloid. Parafollicular cells were not evident. To authors' knowledge, this is first report intracardiac gland in valve mammal.
A high incidence of hemangiosarcoma (HSA) was observed in mice treated for 2 years with siponimod, a sphingosine-1-phosphate receptor 1 (S1P1) functional antagonist, while no such tumors were rats under the same treatment conditions. In 3-month rat (90 mg/kg/day) and 9-month mouse (25 75 vivo mechanistic studies, vascular endothelial cell (VEC) activation both species, but VEC proliferation persistent increases circulating placental growth factor (PLGF2) only seen mouse. mice, these effects...
An 8-year-old mixed breed male dog was presented with a mass on the rostral mandibular gingiva that quickly emerged 2-3 weeks prior to presentation. The firm, smooth, well-circumscribed, and approximately 2 × 1 0.5 cm in size left canine tooth (304). Clinical examination radiographs were unremarkable. Cytology revealed two distinct cell populations, consisting of numerous uniform-appearing epithelial clusters low numbers individual spindle cells. Epithelial cells had mild anisocytosis...
From 1999 to 2002 samples from 114 free-ranging polar bears (Ursus maritimus) were collected in the municipality of Scoresby Sound, East Greenland, detect levels organochlorines and potential histopathologic changes. Livers 16 female this group evaluated histologically analyzed for hepatic retinol-binding protein by immunohistochemistry. Retinol-binding is main transport retinol, an important vitamin A metabolite bear. Only mild pathologic changes noted on histologic evaluation livers. Small...
A 10-year-old female Golden Retriever was presented for a recheck after the complete removal of low-grade complex mammary carcinoma. The in-house ProCyte Dx automated counts revealed moderate regenerative anemia and eosinophilia. WBC scattergram showed cloud in an unusual place parallel to right monocyte dot plot location. Cells were classified as either monocytes or neutrophils with no clear separation. Complete blood count analysis performed laboratory on Sysmex XT-2000iV analyzer within...
Liver tumors of unknown cause have frequently been described in polar bears. Concurrent decrease vitamin A levels and chronic liver disease are associated with hepatic carcinogenesis humans. More than 90% the body's is stored liver, where it bound to an intracellular retinol-binding protein (RBP). Therefore, this retrospective study, RBP was assessed by immunohistochemistry sections 11 Two these bears had hepatocellular carcinoma, four showed other changes, five normal livers. In livers,...
Abstract The mitotic count (MC) is an important histological parameter for prognostication of malignant neoplasms. However, it has inter- and intra-observer discrepancies due to difficulties in selecting the region interest (MC-ROI) identifying/classifying figures (MFs). Recent progress field artificial intelligence allowed development high-performance algorithms that may improve standardization MC. As algorithmic predictions are not flawless, computer-assisted review by pathologists ensure...
A 7-year-old male castrated Maine Coon cat presented with edema of the right hindlimb and a markedly enlarged popliteal lymph node. CBC showed neutropenia 1.5 × 103 /μL. Radiographs ultrasonographic examination were unremarkable. Cytology node revealed mixed population cells, consisting predominantly medium to large plasmacytoid lymphocytes, low moderate numbers well-differentiated plasma cells small lymphocytes. Plasmacytoid lymphocytes had round nuclei finely stippled chromatin one...