A5080377095- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Virus-based gene therapy research
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Parasitic Infections and Diagnostics
- Medical Imaging and Pathology Studies
- Tumors and Oncological Cases
- Mast cells and histamine
- Toxoplasma gondii Research Studies
- AI in cancer detection
- Oral and Maxillofacial Pathology
- Microbial infections and disease research
- T-cell and B-cell Immunology
- Reproductive Physiology in Livestock
- Veterinary Medicine and Surgery
- Bone Tumor Diagnosis and Treatments
- Rabbits: Nutrition, Reproduction, Health
- Cancer Genomics and Diagnostics
- Digital Imaging for Blood Diseases
- Ocular Surface and Contact Lens
- Pneumocystis jirovecii pneumonia detection and treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Glaucoma and retinal disorders
- Heterotopic Ossification and Related Conditions
University of Veterinary Medicine Vienna
2014-2024
MODUL University Vienna
2019-2020
The mitotic count (MC) is an important histological parameter for prognostication of malignant neoplasms. However, it has inter- and intraobserver discrepancies due to difficulties in selecting the region interest (MC-ROI) identifying or classifying figures (MFs). Recent progress field artificial intelligence allowed development high-performance algorithms that may improve standardization MC. As algorithmic predictions are not flawless, computer-assisted review by pathologists ensure...
Microscopic evaluation of hematoxylin and eosin-stained slides is still the diagnostic gold standard for a variety diseases, including neoplasms. Nevertheless, intra- interrater variability are well documented among pathologists. So far, computer assistance via automated image analysis has shown potential to support pathologists in improving accuracy reproducibility quantitative tasks. In this proof principle study, we describe machine-learning-based algorithm diagnosis 7 most common canine...
Although the incidence of uterine disorders in pet rabbits is high there are only a few retrospective studies and case reports on genital tract disease female rabbits. Uterine were assessed 50 In 31 with suspected clinical disease, medical records further reviewed regarding signs, diagnostic workup, treatment as well outcome itself. adenocarcinoma (54%) was most frequently diagnosed, followed by endometrial hyperplasia (26%). Serosanguineous vaginal discharge predominant sign observed rabbit...
Leukocyte ratios correlate with outcome in several human cancers. Little is known about their prognostic significance mast cell tumour (MCT). The aim of the study was to evaluate pretreatment leukocyte concentrations and dogs MCT for survival. Medical records 92 were retrospectively reviewed. Tumour diagnosis made by biopsy or fine-needle aspirate. Only without prior treatment included. Eosinophil, lymphocyte, monocyte neutrophil concentration obtained ADVIA 2120™ (Siemens Healthcare,...
Thymomas are rarely recorded in rabbits, and the literature includes comparatively few cases. Medical records were reviewed to identify all pet rabbits which a mediastinal mass was diagnosed between Feb 2007 Jan 2010. Signalment, history, clinical signs, diagnostic work-up (including laboratory data, imaging, ultrasound-guided fine-needle aspiration of mass), treatment modalities, survival time, histologic findings evaluated. Cytologic and/or histopathologic examinations revealed thymomas...
Identification of Encephalitozoon cuniculi (E. cuniculi) as a possible causative agent for cataracts and uveitis in cats.Within 12-month study period, cats that were presented with focal anterior cortical or mature cataract secondary underwent complete ophthalmic examination, blood count, serum biochemistry, serologic tests E. feline immunodeficiency virus (FIV), infectious peritonitis (FIP), leukemia (FeLV) Toxoplasma gondii (T. gondii). PCR DNA detection T. well cytologic examination...
Abstract Differentiation between resident mature lymphocyte populations and small cell lymphoma cannot be made by cytological review alone remains challenging in histopathological review. These cases warrant application of complementary tools like PCR ‐based immunoglobulin ( IG ) T‐cell receptor TCR clonality testing for confirmation. In this prospective study, diagnostic sensitivity specificity different primer sets routine diagnosis feline gamma TCRG complete heavy chain IGH gene...
Objectives The purpose of this study was to specify lymphoma subtypes according the World Health Organization (WHO) classification in a group cats and investigate their potential prognostic value. Methods Records from University Veterinary Medicine Vienna suffering were reviewed retrospective study. To diagnose various specified WHO classification, histopathological immunohistochemical examinations, as well clonality assays some cases, performed. Results Of 30 included classified guidelines,...
Variation in nuclear size and shape is an important criterion of malignancy for many tumor types; however, categorical estimates by pathologists have poor reproducibility. Measurements characteristics can improve reproducibility, but current manual methods are time-consuming. The aim this study was to explore the limitations develop alternative morphometric solutions canine cutaneous mast cell tumors (ccMCTs). We assessed following evaluation accuracy, prognostic utility: (1) anisokaryosis...
Lipid droplets were identified as important players in biological processes of various tumor types. With emphasis on lipid droplet-coating proteins (perilipins, PLINs), this study intended to shed light the presence and formation canine osteosarcoma. For purpose, osteosarcoma tissue samples (n = 11) analyzed via immunohistochemistry electron microscopy for (PLINs). Additionally, we used cell lines D-17 COS4288 2D monolayer 3D spheroid (cultivated 7, 14, 21 days) vitro models, further by...
Abstract Histopathological examination of tissue samples is essential for identifying tumor malignancy and the diagnosis different types tumor. In case lymphoma classification, nuclear size neoplastic lymphocytes one key features to differentiate subtypes. Based on combination artificial intelligence advanced image processing, we provide a workflow classification with regards their (small, intermediate, large). As baseline our testing, use Unet++ model trained histological images canine...
Cell lines are key tools in cancer research allowing the generation of neoplasias animal models resembling initial tumours able to mimic original closely vivo. Canine lymphoma is major hematopoietic malignancy dogs and considered as a valuable spontaneous large model for human Non-Hodgkin's Lymphoma (NHL). Herein we describe establishment characterisation an vivo using canine B-cell cell line CLBL-1 analysing stability induced ability resemble material. was injected into Rag2(-/-)γ(c) (-/-)...
A 3.5-y-old Whippet mixed-breed dog was presented with a history of respiratory distress, exercise intolerance, and generalized demodicosis. Hematologic alterations included marked leukocytosis neutrophilia. Radiographic examination showed diffuse interstitial mild peripheral alveolar lung pattern pneumomediastinum. Because the cytologic bronchoalveolar aspirate not diagnostic persistent perforation upper tract could be ruled out, submitted to thoracoscopy, subsequently left cranial lobe as...
To investigate the distribution and density of conjunctival goblet cells (GC) to study anatomy microscopic characteristics glands associated with eye in guinea pig.Twenty-five pigs were used. Meibomian gland openings counted using biomicroscopy. Conjunctiva, eyelids embedded glycol methacrylate paraffin. Sections stained hematoxylin eosin (H&E), periodic acid Schiff's reaction (PAS) Alcian blue (AB).Highest GC densities found bulbar palpebral region nasal conjunctiva (GC index: 13.7-16.4%)....
Abstract Bilateral phacoclastic uveitis caused by lenticular infection with E ncephalitozoon cuniculi is described in a snow leopard. The diagnosis was made on histopathological and immunohistological examination of both eyes submitted after postmortem examination. There positive antibody titer for . (1:320). Polymerase chain reaction ( PCR ) sequence analysis formalin‐fixed, paraffin‐embedded ocular tissue detected the DNA , strain III No other systemic lesions attributable to were identified.
A 7-year-old male Boxer with a 3.5-year history of atopy and food hypersensitivity was presented multiple poorly circumscribed nodules maculae the skin tongue, jaundiced mucosal membranes. Cytologic histopathologic examination lesions revealed cutaneous epitheliotropic lymphoma. Cells were CD3(+) CD8(+) in flow cytometry. The CBC showed moderate leukocytosis 16% atypical lymphocytes irregularly cleaved nuclei. Flow cytometric phenotyping peripheral blood an elevated proportion T-lymphocyte...
Lymphoma is the most common tumour of domestic cats, developing frequently in small intestine. Feline intestinal lymphoma predominantly demonstrates a T-cell immunophenotype identified by standard immunopositivity for T cells with CD3 or B CD20. In contrast, wide spectrum immunohistochemical antibodies are applied humans to diagnose various specific subtypes according WHO classification. Our aim was augment our knowledge immunophenotypes feline non-B-cell lymphomas forming macroscopic masses...
Abstract Objective To investigate the density and distribution of conjunctival goblet cells (GC) study anatomy microscopic characteristics glands associated with eye in chinchillas (Chinchilla Laniger). Procedure 12 were included study. Conjunctiva (divided into four regions), eyelids, embedded paraffin wax, sectioned, stained, analyzed. Results Highest GC densities found palpebral region nasal temporal conjunctiva both eyelids (GC index: 25.1–18.2%), lowest densities, bulbar marginal...
Summary Three mongrel dogs, aged 10 months (case 1), 14 2) and 7.5 years 3), were presented because of ophthalmologic disorders 4 months, 6 7 duration, respectively. All three dogs offspring stray from Hungary Serbia had positive serum antibody titres against Encephalitozoon (E.) cuniculi. The two young showed unilateral, the older dog bilateral chronic anterior uveitis with posterior synechia focal cortical cataract. fundi that could be evaluated developed tapetal hyporeflective lesions in...