A5035562317- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Arrhythmias and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Quality and Safety in Healthcare
- Acute Ischemic Stroke Management
- Occupational Health and Safety in Workplaces
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Therapeutic Uses of Natural Elements
- Botulinum Toxin and Related Neurological Disorders
- Heavy Metal Exposure and Toxicity
- Cancer therapeutics and mechanisms
- Heavy metals in environment
- Forensic Fingerprint Detection Methods
- Forensic and Genetic Research
- Forensic Entomology and Diptera Studies
Centro de Investigación en Red en Enfermedades Cardiovasculares
2024
Complejo Hospitalario Universitario de Santiago
2021-2024
Instituto de Investigación Sanitaria de Santiago
2024
Universidade de Santiago de Compostela
2021-2024
Abstract Cerro de Pasco, Peru, has been excessively contaminated with heavy metals due to high mining activities in the region. We investigated presence of chronic exposure children living Pasco and its effect on health. Heavy metal concentrations were determined hair samples collected from 78 a region exposed an open-pit mine (Paragsha region) other 16 unexposed (Carhuamayo region). Children showed statistically significant higher concentration aluminum, antimony, arsenic, cadmium,...
The SCN5A gene polymorphism histidine-558-to-arginine (H558R) has been associated with atrial fibrillation (AF) and may affect the therapeutic effects of flecainide. This study aimed to assess prevalence H558R in a European cohort patients AF examine its association flecainide's on recurrence toxicity.
Abstract Background The CYP2D6 enzyme, coded by the gene, is primary metabolic pathway for flecainide.(1,2) Over years, studies on how different variants of this gene affect flecainide metabolism and efficacy have yielded contradictory results.(3–7) This likely due to fact that pharmacogenetic classifications were not standardized until 2017.(8,9) Purpose To date, there has been no published study using a classification assess toxicity across phenotypes; therefore, we decided this. Methods...
Abstract Background Certain mutations in the SCN5A gene alter function of type V voltage-gated cardiac sodium channel and therapeutic effect flecainide.(1) One such mutation, H558R, represents a polymorphism with high prevalence associated development atrial fibrillation (AF).(2–5) Purpose We aim to determine its relationship efficacy adverse effects flecainide, as well describe for first time cohort European patients AF. Methods conducted study collecting data through indirect methods,...
Abstract Background Risk stratification in patients with non-ST elevation acute coronary syndrome (NSTEACS), becomes a priority after its diagnosis, due to the fact that it gives us information about prognosis and has crucial implications. The latest guidelines of European Society Cardiology (ESC) suggest new proposal risk dividing three different groups: “low”, “high” “very high risk”. Thus, they remove intermediate group defended previous (2015). Purpose Our aim was identify an following...