A5091844912- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Angiogenesis and VEGF in Cancer
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Apelin-related biomedical research
- Pancreatic function and diabetes
- Diabetes Management and Research
- Neuroscience of respiration and sleep
Rutgers, The State University of New Jersey
2018-2025
Rutgers Health
2025
Rutgers New Jersey Medical School
2018-2024
In female, but not male, mice, bone morphogenetic protein (BMP) 8B affects energy homeostasis by inhibiting AMP activated kinase (AMPK) in the ventromedial hypothalamus (VMH). VMH glucose-inhibited (GI) neurons that express neuronal nitric oxide synthase (nNOS) increase blood glucose an AMPK dependent fashion. We tested hypothesis BMP8B increases inhibition on nNOS-GI neurons. found more nNOS expressed receptor females than males. Moreover, blunted activation of GI low glucose. Thus, may...
Abstract The neuropilin receptors and their secreted semaphorin ligands play key roles in brain circuit development by regulating numerous crucial neuronal processes, including the maturation of synapses migration GABAergic interneurons. Consistent with its developmental roles, 2 ( Nrp2 ) locus contains polymorphisms patients autism spectrum disorder (ASD). Nrp2-deficient mice show autism-like behavioral deficits propensity to develop seizures. In order determine pathophysiology deficiency,...
Perifornical hypothalamus (PFH) orexin glucose-inhibited (GI) neurons that facilitate arousal have been implicated in hypoglycemia awareness. Mice lacking exhibit narcolepsy, and mediates the effect of antinarcolepsy drug modafinil. Thus, awareness may require a certain level for sympathetic symptoms (e.g., tremors, anxiety). Recurrent (RH) causes unawareness. We hypothesize RH impairs glucose sensitivity PFH GI modafinil normalizes these restores after RH. Using patch-clamp recording, we...
Glucose-inhibited (GI) neurons of the ventromedial hypothalamus (VMH) depend on neuronal nitric oxide synthase (nNOS) and AMP-activated protein kinase (AMPK) for activation in low glucose. The Lopez laboratory has shown that effects estrogen brown fat thermogenesis white browning require inhibition VMH AMPK. This effect was mediated by downstream lateral (LH) orexin (1,2). We previously showed inhibits GI glucose inhibiting AMPK (3). Thus, we hypothesized AMPK- nNOS-dependent project to...
<p> </p> <p>Perifornical hypothalamus (PFH) orexin glucose-inhibited (GI) neurons that facilitate arousal have been implicated in hypoglycemia awareness. Mice lacking exhibit narcolepsy and mediates the effect of anti-narcolepsy drug, modafinil. Thus, awareness may require a certain level for sympathetic symptoms (e.g., tremors, anxiety). Recurrent (RH) causes unawareness. We hypothesize RH impairs glucose sensitivity PFH orexin-GI modafinil normalizes these restores after...
Abstract The neuropilin receptors and their secreted semaphorin ligands play key roles in brain circuit development by regulating numerous crucial neuronal processes, including the maturation of synapses migration GABAergic interneurons. Consistent with its developmental roles, 2 ( Nrp2 ) locus contains polymorphisms patients autism spectrum disorder (ASD). deficient mice show autism-like behavioral deficits propensity to develop seizures. In order determine pathophysiology deficiency, we...
<p> </p> <p>Perifornical hypothalamus (PFH) orexin glucose-inhibited (GI) neurons that facilitate arousal have been implicated in hypoglycemia awareness. Mice lacking exhibit narcolepsy and mediates the effect of anti-narcolepsy drug, modafinil. Thus, awareness may require a certain level for sympathetic symptoms (e.g., tremors, anxiety). Recurrent (RH) causes unawareness. We hypothesize RH impairs glucose sensitivity PFH orexin-GI modafinil normalizes these restores after...