A5068657750- Bone health and osteoporosis research
- Radiology practices and education
- Medical Imaging and Analysis
- Body Composition Measurement Techniques
- Hip and Femur Fractures
- Dental Radiography and Imaging
- Bone fractures and treatments
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Nutrition and Health in Aging
- Spinal Fractures and Fixation Techniques
- Bone health and treatments
- Artificial Intelligence in Healthcare and Education
- Spine and Intervertebral Disc Pathology
- Medical Imaging Techniques and Applications
- Innovations in Medical Education
- Radiomics and Machine Learning in Medical Imaging
- Bone and Joint Diseases
- Orthopedic Surgery and Rehabilitation
- Medical Image Segmentation Techniques
- Genomics and Chromatin Dynamics
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Hemoglobinopathies and Related Disorders
- Healthcare professionals’ stress and burnout
University of Exeter
2016-2025
Rutgers, The State University of New Jersey
2025
Rutgers Health
2025
Health & Life (Taiwan)
2025
Corewell Health
2025
University of Otago
2012-2023
University of Oxford
2023
City, University of London
2021
Siemens Healthcare (United States)
2021
University of Northampton
2021
It remains unclear whether non–animal-derived dietary protein sources (and therefore vegan diets) can support resistance training-induced skeletal muscle remodeling to the same extent as animal-derived sources. In Phase 1, 16 healthy young adults (m = 8, f 8; age: 23 ± 1 y; BMI: kg/m2) completed a 3-d intervention (high protein, 1.8 g·kg bm−1·d−1) where was derived from omnivorous (OMNI1; n 8) or exclusively non-animal (VEG1; sources, alongside daily unilateral leg exercise. Resting and...
Background/Aim: Osteoporosis is a global health concern causing severe fractures, and timely diagnosis with thorough bone assessment crucial for effective management. Diagnostic tools such as Bindex<sup>®</sup> (a novel ultrasound-based diagnostic technology) DXA (X-ray-based) play key role in identifying assessing conditions. This study aimed to evaluate compare these two approaches' overall acceptability, comfort, preference. Feelings of pain perceptions regarding the scan length during...
The CYP 17 and 19 genes encode 17α-hydroxylase/17,20-lyase aromatase, respectively, both involved in sex hormone synthesis. We investigated the association between 2 common polymorphisms 1) promoter region (T→C substitution) of 17, 2) exon 3 (G→A) 19, bone mineral density (BMD) serum androgen/estradiol, a case-control study 252 postmenopausal women aged 64.5 ± 9.2 yr (mean sd). There was no significant difference estradiol concentrations cases (n = 136) controls 116). genotype significantly...
A previous modelling study predicted that the forces applied by extensor muscles to stabilise lumbar spine would be greater in spines have a larger sagittal curvature (lordosis). Because force-generating capacity of muscle is related its size, it was hypothesised size subject their lordosis. Magnetic resonance imaging (MRI) data were obtained, together with age, height, body mass and back pain status, from 42 female subjects. The volume (multifidus erector spinae) caudal mid-lumbar level...
Exercise is an effective approach for developing bone mass and adolescence a key period to optimize health. However, sports-specific training may have different effects on outcomes. This study examined the differences outcomes between osteogenic (football) nonosteogenic (swimming cycling) sports control group in male adolescents.One hundred twenty one males (13.1 ± 0.1 yr) were measured: 41 swimmers, 37 footballers, 29 cyclists, 14 controls. Dual energy X-ray absorptiometry measured mineral...
Chromatin is essentially an array of nucleosomes, each which consists the DNA double-stranded fiber wrapped around a histone octamer. This organization supports cellular processes such as replication, transcription, and repair in all eukaryotes. Human H4 encoded by fourteen canonical genes, differing at nucleotide level but encoding invariant protein. Here, we present cohort 29 subjects with de novo missense variants six genes (H4C3, H4C4, H4C5, H4C6, H4C9, H4C11) identified whole-exome...
Physical inactivity is a highly modifiable risk factor for the development of osteoporosis but, due to lack research that has precisely and objectively meaured physical activity (PA) relevant bone, specific contribution PA can make bone health poorly understood. This study examined whether more precise measure relelvant was associated with meaures in pre- post-menopausal women UK Biobank.
Adolescence is a crucial period for bone development, and exercise can enhance acquisition during this of life. However, it not known how the different loading sports practiced affect in adolescent male athletes. Therefore, purpose present study was to determine 1-year longitudinal among males involved osteogenic (football) non-osteogenic (swimming cycling) compare with active controls. A total 116 aged 12 14 years at baseline were followed 1 year: 37 swimmers, footballers, 28 cyclists, Bone...
Purpose The determinants of areal bone mineral density (aBMD) and hip geometry estimates in adolescent athletes are poorly understood. This study aimed to identify the aBMD male athletes. Methods One hundred twenty-one men (13.1 ± 0.1 yr) were measured: 41 swimmers, 37 footballers, 29 cyclists, 14 controls. Dual energy X-ray absorptiometry measured at lumbar spine, femoral neck total body. Hip structural analysis evaluated neck. Multiple linear regression examined contribution sports...
Material Linked-read whole genome sequencing (WGS) presents a new opportunity for cost-efficient singleton in place of traditional trio-based designs while generating informative-phased variants, effective recessive disorders when parental DNA is unavailable. Methods We have applied linked-read WGS to identify novel causes Meier-Gorlin syndrome (MGORS), condition recognised by short stature, microtia and patella hypo/aplasia. There are eight genes associated with MGORS date, all encoding...
Osteoporosis is a skeletal disease associated with high morbidity, mortality and increased economic costs. Early prevention during adolescence appears to be one of the most beneficial practices. Exercise an effective approach for developing bone mass puberty, but some sports may have positive or negative impact on accrual. Plyometric jump training has been suggested as type exercise that can augment bone, its effects adolescent not rigorously assessed. The aims PRO-BONE study are to: 1)...