A5029718664- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Nail Diseases and Treatments
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer Immunotherapy and Biomarkers
- Chemotherapy-related skin toxicity
- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- CAR-T cell therapy research
- Dermatology and Skin Diseases
- Dermatological and COVID-19 studies
- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Cancer Treatment and Pharmacology
- Autoimmune and Inflammatory Disorders
- Genital Health and Disease
- Dermatological and Skeletal Disorders
- Histiocytic Disorders and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Soft tissue tumor case studies
- Oral and gingival health research
- Soft tissue tumors and treatment
- Vascular Malformations and Hemangiomas
- Tumors and Oncological Cases
University of Tsukuba
2017-2024
Mayo Clinic
2022
National Hospital Organization Mito Medical Center
2017-2021
Institute of Dermatology
2021
Tokyo Rosai Hospital
1994
Yamaguchi University Hospital
1971
Immune checkpoint inhibitors (ICIs) bring prognostic benefits to patients with malignancies. However, there is a substantial number of whose lesions are not improved by ICIs. In addition, ICIs may cause immune-related adverse events (irAEs), which could lead an unfavorable prognosis fatal consequences. Therefore, we conducted retrospective study evaluate the utility circulating sPD-L1 (soluble programmed cell death 1 ligand 1) as biomarker in advanced melanoma treated anti-PD-1 (programmed...
Recent clinical trials have demonstrated the efficacy of immune checkpoint inhibitors (ICIs) for treating melanoma. However, these previous studies comprised mainly Caucasian populations, in which cutaneous melanoma (CM) is major type. In contrast, Asian populations a distinct profile and show much higher frequencies acral lentiginous (ALM) mucosal (MCM). Compared with CM, ALM MCM poorer response to ICIs, but mechanisms not been fully understood. To evaluate status each subtype, we examined...
Pityriasis rosea (PR), a benign and self-limiting skin disorder, typically manifests as single initial lesion known the herald patch. The patch is commonly followed by development of secondary erythematous papules plaques, aligning with Langer's lines to form specific distribution pattern, resembling Christmas tree on back V-shaped pattern upper chest. Therefore, diagnosing PR may not be difficult based its typical clinical presentation. In contrast, cases atypical presentation have been...
The exact mechanisms of the imiquimod (IMQ)-induced antitumor effect have not been fully understood. Although both topical IMQ treatment and anti-PD-1 antibody may be used for primary skin lesions or metastases various cancers, efficacy each monotherapy these is insufficient. Using a murine tumor model human samples, we aimed to elucidate detailed IMQ-induced analyzed combination therapy plus antibody. Topical significantly suppressed growth MC38 in wildtype mice. upregulated interferon γ...
Abstract Background Critical care ultrasonography (CCUS) has become a daily diagnostic tool for intensivists. While the effective training measures ultrasound novices are discussed widely, best curriculum to retain long-term proficiency is yet be determined. Methods medicine fellows who underwent an introductory CCUS workshop were randomly allocated into standard (ST) or intensive (IT) group. The IT group received 8-h besides standardized fellowship education that ST received. Participant...
Eribulin mesylate (ERB) is a synthetic analog of halichondrin B, inhibiting tumor cell growth by disrupting microtubule function. Recently, anticancer drugs have been shown to not only act directly on cells but also exert antitumor effects modifying the environment. Although ERB has speculated modify microenvironment including immune response tumors, precise mechanism remains unclear. In our study, suppressed MC38 colon cancer in wildtype mice, whereas failed inhibit Rag1-deficient mice...
Abstract is missing (Short communication)
Graphical Abstract We show a case of 69-year-old man with perforating collagenosis, which is rare dermatosis commonly associated diabetes mellitus. Papules and plaques keratotic plugs are distinctive clinical characteristic collagenosis. Representative images in our article can enhance the understanding key concepts collagenous.