A5113309397- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- CRISPR and Genetic Engineering
- Polydiacetylene-based materials and applications
- Geomechanics and Mining Engineering
- Primate Behavior and Ecology
- Photochromic and Fluorescence Chemistry
- biodegradable polymer synthesis and properties
- Neural and Behavioral Psychology Studies
- Membrane Separation and Gas Transport
- Simulation and Modeling Applications
- Congenital heart defects research
- Geotechnical Engineering and Soil Stabilization
- Mind wandering and attention
- Genetics, Aging, and Longevity in Model Organisms
- Cellular Mechanics and Interactions
- Geotechnical and Geomechanical Engineering
- Pharmacological Effects and Toxicity Studies
- Human-Animal Interaction Studies
- Micro and Nano Robotics
- Protein purification and stability
- Infrared Target Detection Methodologies
- Membrane Separation Technologies
- Job Satisfaction and Organizational Behavior
- Polyoxometalates: Synthesis and Applications
Sichuan University
2025
Chinese Academy of Sciences
2015-2024
Institute of Genetics and Developmental Biology
2015-2024
Center for Excellence in Brain Science and Intelligence Technology
2018-2023
University of Chinese Academy of Sciences
2018-2021
Institute of Software
2021
Guangzhou Institutes of Biomedicine and Health
2018
China University of Political Science and Law
2017
Despite the substantial progress made in identifying genetic defects autism spectrum disorder (ASD), etiology for majority of ASD individuals remains elusive. Maternal exposure to valproic acid (VPA), a commonly prescribed antiepileptic drug during pregnancy human, has long been considered risk factor contribute susceptibility offspring from epidemiological studies humans. The similar exposures murine models have provided tentative evidence support finding human epidemiology. However,...
Monogenic mutations in the SHANK3 gene, which encodes a postsynaptic scaffold protein, play causative role autism spectrum disorder (ASD). Although number of mouse models with Shank3 have been valuable for investigating pathogenesis ASD, species-dependent differences behaviors and brain structures post considerable challenges to use small animals model ASD translate experimental therapeutics clinic. We used clustered regularly interspersed short palindromic repeat/CRISPR-associated nuclease...
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that affects social interaction and behavior. Mutations in the gene encoding chromodomain helicase DNA-binding protein 8 (CHD8) lead to autism symptoms macrocephaly by haploinsufficiency mechanism. However, studies of small animal models showed inconsistent findings about mechanisms for CHD8 deficiency-mediated macrocephaly. Using nonhuman primate as model system, we found CRISPR/Cas9-mediated mutations embryos...
Abstract Along with the quick advancements in enzyme technology, inactivation has emerged as key barrier for enzymes to be fully utilized biocatalysts. Here, a novel strategy is presented preservation of enzymatic activity even after heat treatment by grafting onto thermal responsive block copolymer via an activated ester‐amine reaction. A new water‐soluble ester monomer, acrylic polyethylene glycol (PEG) functionalized 3‐fluoro‐4‐hydroxybenzoate synthesized. This monomer and...
Abstract Background SHANK3 gene is a highly replicated causative for autism spectrum disorder and has been well characterized in multiple Shank3 mutant rodent models. When compared to rodents, domestic dogs are excellent animal models which study social cognition as they closely interact with humans exhibit similar behaviors. Using CRISPR/Cas9 editing, we recently generated dog model carrying mutations, displayed of autism-like behaviors, such impairment heightened anxiety. However, the...
Attentional biases toward substance-related stimuli might play a contributing role in addictive behaviors.This study investigated the selective attention to heroin dependents receiving methadone maintenance therapy.Thirty outpatients treatment for dependence and 38 healthy controls completed visual probe task with concurrent eye movement monitoring.The results showed that group reacted faster probes associated pictures than neutral pictures, they directed more initial fixations maintained...