A5091589150- Immune cells in cancer
- Legal Systems and Judicial Processes
- Legal principles and applications
- Cancer-related molecular mechanisms research
- Eicosanoids and Hypertension Pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- Gene Regulatory Network Analysis
- Immune Response and Inflammation
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Corporate Insolvency and Governance
- Molecular Communication and Nanonetworks
Royal College of Surgeons in Ireland
2020-2022
Abstract Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, critical for IL-10-induced modulation mitochondrial dynamics oxidative respiration. Mechanistically, catalytic activity presence Arg2 crucial phosphorylation. We further mediates this process by increasing complex II (succinate dehydrogenase)....
Macrophages are plastic cells playing a crucial role in innate immunity. While fundamental responding to infections, when persistently maintained pro-inflammatory state they can initiate and sustain inflammatory diseases. Therefore, strategy that reprograms macrophages toward an anti-inflammatory phenotype could hold therapeutic potential context. We have recently shown arginase 2 (Arg2), mitochondrial enzyme involved arginine metabolism, promotes the resolution of inflammation it is...
Demyelination of neurons can compromise the communication performance between cells as absence myelin attenuates action potential propagated through axonal pathway. In this work, we propose a hybrid experimental and simulation model for analyzing demyelination effects on neuron communication. The experiment involves locally induced using Lysolecithin from this, myelination index is empirically estimated analysis cell images. This then coupled with modified Hodgkin-Huxley computational to...
Recent evidence highlights the importance of mitochondrial bioenergetics and dynamics in regulating macrophage polarisation. We demonstrate that Arginase-2 (Arg2), one two arginase isoforms is an interleukin-10 (IL-10) regulated gene localized at mitochondria inflammatory macrophages critical for IL-10 induced restoration oxidative respiration these cells. show radically affects by promoting a state ‘fusion’, which likely facilitates higher we observe. subsequently established Arg2 regulates...