A5017868976- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Child and Adolescent Psychosocial and Emotional Development
- Family and Disability Support Research
- Psychoanalysis and Psychopathology Research
- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Mental Health Research Topics
- Treatment of Major Depression
- Social Policies and Family
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Adolescent and Pediatric Healthcare
- Personality Disorders and Psychopathology
- Family Caregiving in Mental Illness
- Health, Medicine and Society
- Maternal Mental Health During Pregnancy and Postpartum
- Mental Health Treatment and Access
- Psychosomatic Disorders and Their Treatments
- Olfactory and Sensory Function Studies
- Mind wandering and attention
- Psychiatric care and mental health services
- Cognitive Functions and Memory
- Medication Adherence and Compliance
Université de Bordeaux
2016-2025
Centre Hospitalier Charles Perrens
2016-2025
Fondation FondaMental
2014-2024
Hôpital Albert-Chenevier
2021-2024
Assistance Publique – Hôpitaux de Paris
2020-2024
Hôpital Fernand-Widal
2020-2024
NutriNeuro
2022
Laboratoire d'Optique Appliquée
2021
Université Paris Cité
2020-2021
Sorbonne Université
2021
Objective: Duration of untreated illness represents a potentially modifiable component any diagnosis‐treatment pathway. In bipolar disorder (BD), this concept has rarely been systematically defined or not applied to large clinically representative samples. Method: well‐characterized sample 501 patients with BD, we estimated the duration (DUB: interval between first major mood episode and treatment stabilizer). Associations DUB clinical onset temporal sequence key milestones were examined....
<h3>OBJECTIVE</h3> Early recanalisation by thrombolysis is a conclusive therapy for acute ischaemic stroke. But this may increase the risk of intracerebral haemorrhage or severe brain oedema. The purpose was to evaluate usefulness quantitative measurement cerebral blood flow single photon emission computed tomography (SPECT) in predicting oedema, and determining therapeutic options hemispheric <h3>METHODS</h3> relation studied retrospectively between initial regional (rCBF) quantitatively...
The clinical presentation, course, and comorbidities of bipolar disorder type I are highly heterogeneous, this variability remains poorly predictable. Certain onset characteristics (eg, age polarity at onset) may delineate subgroups differing in expression outcome.We retrospectively investigated the association between both (DSM-IV) 2 independent adult samples: 480 French patients assessed 1992-2006 (patients had been recruited from 3 university-affiliated psychiatry departments) 714 US...
Background: Normothymic states in bipolar disorders are generally considered to be devoid of severe symptoms. However, patients present subsyndromal symptoms for half their lives, and often have comorbid psychiatric disorders. If we go beyond the concept temperamental features, can identify certain emotional characteristics distinguishing normothymic from normal controls? We previously showed, using self‐completed questionnaires, that display higher levels lability intensity than controls....
Background Raising a child with an autism spectrum disorder (ASD) implies significant stress levels and changes in family functioning. Most studies deal parental difficulties, whereas those focusing on self-reported support needs related to ASD are fewer, especially France. Our objective was explore French sample the of parents children so as provide recommendations for support.Method Parents were interviewed (N = 162, including 84 controls), content analysis performed from responses.Results...
Poor adherence to medication is frequent in bipolar disorder (BD) and has been associated with several factors. To date, the relationship between low neuropsychological functioning BD still unclear. As age might have opposing influences on adherence, our aim was investigate this link a particular focus effect of age.In cross-sectional study, we included 353 patients divided into two age-groups (16-46; 47-71) from French cohort diagnosed (type I, II, NOS) strictly euthymic. All had...
The boundaries between mood states in bipolar disorders are not clear when they associated with mixed characteristics. This leads to some confusion define appropriate therapeutic strategies. A dimensional approach might help better moods and more specifically those features. Therefore, we proposed a new tool based on approach, built priori five sub-scales focus emotional reactivity rather than exclusively tonality. study was designed validate this MAThyS Scale (Multidimensional Assessment of...
Abstract Bipolar disorder (BD) has been associated with premature cellular aging shortened telomere length (TL) as compared to the general population. We recently identified a subgroup of young individuals prematurely TL. The aims present study were replicate this observation in larger sample and analyze expression levels genes age or TL subsample these individuals. was measured on peripheral blood DNA using quantitative polymerase chain reaction 542 BD clustering analyses performed. Gene...
Bipolar disorder (BD) and emotion dysregulation present substantial challenges for individuals healthcare providers. Although pharmacological treatments remain the primary approach, psychosocial interventions show promise in addressing sub-threshold symptoms deepening understanding of mood mechanisms. The European Network Emotion Regulation (ENBER) aims to close gap between research clinical practice by offering practical insights clinicians while contributing scientific discourse on BD...
To better understand the disability and heterogeneity in terms of residual symptoms psychosocial cognitive functioning bipolar disorders (BD), individual discrepancies activation early maladaptive schemas (EMS) are relevant to investigate. This study aimed identify profiles EMS investigate association between identified during euthymia. is a cross-sectional study. Clinical data, functioning, neuropsychological performance were collected euthymic outpatients with BD. Clustering was performed...
Although there is a great heterogeneity of depressive states in bipolar patients, only one definition international classifications for describing them. However, this variety seems particularly important to recognize because the possible exacerbation some these by antidepressants. We aimed at assessing whether it distinguish different forms depression using dimensional approach.We characterized 60 patients with Major Depressive Episode (DSM-IV) new tool (MAThyS; Multidimensional Assessment...
Abstract Background Cognitive deficits are a well-established feature of bipolar disorders (BD), even during periods euthymia, but risk factors associated with cognitive in euthymic BD still poorly understood. We aimed to validate classification criteria for the identification clinically significant impairment, based on psychometric properties, estimate prevalence neuropsychological BD, and identify using multivariate approach. Methods investigated performance 476 patients recruited via...
Abstract Objectives Childhood maltreatment, also referred as childhood trauma, increases the severity of bipolar disorders (BD). maltreatment has been associated with more frequent mood recurrences, however, mostly in retrospective studies. Since scarce, further prospective studies are required to identify whether may be time recurrence BD. Methods Individuals BD (N = 2008) were assessed clinically and for at baseline, followed up two years. The cumulative probability over was estimated...
Objective Remitted bipolar disorder (BD) patients frequently present with chronic mood instability and emotional hyper‐reactivity, associated poor psychosocial functioning low‐grade inflammation. We investigated hyper‐reactivity as a dimension for characterization of remitted BD patients, clinical biological factors identifying those without hyper‐reactivity. Method A total 635 adult evaluated in the French Network Bipolar Expert Centers from 2010–2015, were assessed reactivity using...
Inter-episode mood instability has increasingly been considered in bipolar disorder. This study aimed to investigate emotional reactivity as a major dimension for better characterizing remitted patients with subthreshold symptoms and functional status. also whether high-sensitivity C-reactive protein, marker of low-grade inflammation, could be biological dysregulation disorder (BD).Cross-sectional 613 subjects who met Diagnostic Statistical Manual Mental Disorders-Fourth Edition criteria BD...