A5031407581- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Anesthesia and Neurotoxicity Research
- Neural dynamics and brain function
- Nerve injury and regeneration
- Neurological disorders and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- 3D Printing in Biomedical Research
- Neuroscience of respiration and sleep
- Ovarian function and disorders
- Attention Deficit Hyperactivity Disorder
- Reproductive Biology and Fertility
- Point processes and geometric inequalities
- Functional Brain Connectivity Studies
- Neonatal Respiratory Health Research
- Computational Drug Discovery Methods
- Thermal Regulation in Medicine
University of Otago
2015-2025
Brain Research New Zealand
2013-2022
The University of Western Australia
1983
The total number of neurons within six subdivisions the rat basal ganglia was estimated using unbiased stereological counting methods and systematic random sampling techniques. Six young adult rats were perfuse-fixed, their right cerebral hemispheres embedded in glycolmethacrylate, a complete set serial 40-μm sections cut through each hemisphere. After start, subset (e.g., every tenth) these used to estimate volume subdivision Cavalieri's method. same sampled known subvolume (i.e., Nv) by...
The spiny projection neurons are by far the most numerous type of striatal neuron. In addition to being principal striatum, also have an extensive network local axon collaterals which they make synaptic connections with other neurons. However, up now there has been no direct physiological evidence for functional inhibitory interactions between Here we present new that interconnected synapses. To examine properties unitary postsynaptic potentials (IPSPs), dual intracellular recordings were...
Huntington's disease is an autosomal dominant inherited neurodegenerative with motor symptoms that are variably co-expressed mood and cognitive symptoms, in which variable neuronal degeneration also observed the basal ganglia cerebral cortex. We have recently shown symptomatology correlates compartmental pattern of GABAA receptor cell loss striatum. To determine whether phenotypic variability related to cortex, we undertook a double-blind study using unbiased stereological counting methods...
The cellular basis of variable symptoms in Huntington disease (HD) is unclear. One important possibility that degeneration the interneurons cerebral cortex, which play a critical role modulating cortical output to basal ganglia, might significant development symptomatology HD. This study aimed examine whether symptom variability HD specifically associated with interneurons.We undertook double-blind using stereological cell counting methods quantify 3 major types γ-aminobutyric acidergic...
Huntington's disease is an autosomal dominant neurodegenerative characterized by neuronal degeneration in the basal ganglia and cerebral cortex, a variable symptom profile. Although progressive striatal known to occur
Abstract It has been hypothesized that the corticotropin‐releasing hormone (CRH) neurons of hypothalamic paraventricular nucleus (PVN) become hyperactive with age, and even more so in Alzheimer's disease. This hyperactivity could be due to an increased production CRH per neuron, or number PVN producing CRH, both. As a first step elucidating which these biological mechanisms might operative, we have estimated absolute immunoreactive 10 human control subjects between 36 91 years age Alzheimer...
Abstract STUDY QUESTION Does anti-Müllerian hormone (AMH) induce preantral follicle atresia in mice? SUMMARY ANSWER The present findings suggest that AMH-mediated only occurs early follicles before they become sensitive to FSH. WHAT IS KNOWN ALREADY Most prior studies have investigated the ability of AMH inhibit primordial activation. Our previous study showed AMH-overexpressing mice had fewer than expected after accounting for inhibition but reason this was not determined. DESIGN, SIZE,...
ABSTRACT The absolute number of neurons and their spatial distribution yields important information about brain function species comparisons. We studied thalamic parafascicular striatal cholinergic interneurons (CINs) because the are main excitatory input to CINs. This circuit is increasing interest due research showing its involvement in specific types learning behavioral flexibility. In Sprague‐Dawley rat, CINs unknown. They were estimated this study using modern stereological counting...
Pauses in the tonic firing of striatal cholinergic interneurons emerge during reward-related learning and are triggered by neutral cues which develop behavioural significance. In a previous vivo study we have proposed that these pauses may be due to intrinsically generated afterhyperpolarisations (AHPs) evoked excitatory synaptic inputs, including those below threshold for action potential firing. The aim this was investigate mechanism AHPs using brain slice preparation preserved both...
Anti-Müllerian hormone (AMH) is an ovarian regulator that affects folliculogenesis. AMH inhibits the developmental activation of dormant primordial follicles and oocyte within. In more mature follicles, reduces granulosa cell sensitivity to follicle-stimulating (FSH). We examined effects overexpression on stages folliculogenesis, development embryos, with a transgenic mouse overexpresses human in central nervous system neurons under control Thy1.2 promoter (
Brain injury in the premature infant is associated with a high risk of neurodevelopmental disability. Previous small-animal models brain attributable to extreme prematurity typically fail generate spectrum pathology and behavior that closely resembles observed humans, although they provide initial answers numerous cellular, molecular, therapeutic questions. We tested hypothesis exposure rats repeated hypoxia from postnatal day 1 (P1) P3 characteristic white matter neuropathological injury,...