A5076013150- CAR-T cell therapy research
- PARP inhibition in cancer therapy
- Cancer Immunotherapy and Biomarkers
- CRISPR and Genetic Engineering
- Lung Cancer Treatments and Mutations
- Neutropenia and Cancer Infections
- Nuclear Structure and Function
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal and related cancers
- Economic and Financial Impacts of Cancer
- Total Knee Arthroplasty Outcomes
- Cardiovascular Effects of Exercise
- Venous Thromboembolism Diagnosis and Management
- Colorectal and Anal Carcinomas
- Head and Neck Surgical Oncology
- Statistical Methods in Clinical Trials
- Colorectal Cancer Treatments and Studies
- Social Media in Health Education
- RNA regulation and disease
- Health Literacy and Information Accessibility
- Health Systems, Economic Evaluations, Quality of Life
- Cleft Lip and Palate Research
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- Orthopaedic implants and arthroplasty
Boston University
2015-2023
Merck & Co., Inc., Rahway, NJ, USA (United States)
2020-2022
Baim Institute for Clinical Research
2018
Harvard University
2016
Pembrolizumab, a PD-1 inhibitor, demonstrated anti-tumour activity and tolerability in patients treated with sorafenib advanced hepatocellular carcinoma KEYNOTE-224. Longer-term efficacy safety after ∼2.5 years of additional follow-up are reported.Adults confirmed who experienced progression or intolerance to treatment received pembrolizumab 200 mg every 3 weeks for ≤35 cycles until progression, unacceptable toxicity, withdrawal consent investigator decision. The primary end-point was...
Abstract Therapeutic approaches for clear cell renal carcinoma (ccRCC) remain limited; however, chimeric antigen receptor (CAR) T-cell therapies may offer novel treatment options. CTX130, an allogeneic CD70-targeting CAR product, was developed the of advanced or refractory ccRCC. We report that CTX130 showed favorable preclinical proliferation and cytotoxicity profiles completely regressed RCC xenograft tumors. also results from 16 patients with relapsed/refractory ccRCC who received in a...
Hutchinson-Gilford progeria syndrome (HGPS) is an ultrarare disorder associated with premature death due to cardiovascular events during the second decade of life. However, because its rarity (107 identified living patients), natural history cardiac disease remains uncharacterized. Therefore, meaningful end points for clinical trials have been difficult establish.To examine course appearance abnormalities in patients HGPS identify use future trials.In this prospective, cross-sectional,...
A prior randomized controlled trial of social media exposure at Circulation determined that did not increase 30-day page views. Whether insufficient intensity contributed to these results is uncertain.Original article manuscripts were compared with no (control) beginning in January 2015. Social consisted Facebook and Twitter posts on the journal's accounts. To intensity, a larger base followers was built using advertising organic growth, presented triplicate boosted retweeted Twitter. The...
<h3>Background</h3> Clear cell renal carcinoma (ccRCC) is the most common subtype of tumors. Patients with ccRCC who fail checkpoint inhibitors (CPIs) and tyrosine kinase (TKIs) have a poor prognosis. Preclinical studies identified substantial expression CD70 in tumor samples. Here, we report results from Phase 1 dose-escalation study CTX130™, CD70-targeting allogeneic CAR T therapy patients ccRCC. <h3>Methods</h3> COBALT-RCC (NCT04438083) 1, open-label, multicenter, global evaluating safety...
Little is known regarding the risk of hepatic steatosis (HS) among adult children affected parents. We examined association between parental and offspring HS in multigenerational Framingham Heart Study, which characterized using computed tomography.We performed multivariable logistic regression models adjusted for age, sex, alcohol use, body mass index to generate odds according HS. determined proportion participants with presence or absence hypertension, diabetes, obesity (BMI ≥30 kg/m2 )....
To dêtermine the reliability of radiographic assessment knee osteoarthritis (OA) by nonclinician readers compared to an experienced radiologist.The radiologist trained 3 nonclinicians evaluate characteristics OA. The and read preoperative films 36 patients prior total replacement. Intrareader interreader were measured using weighted κ statistic intraclass correlation coefficient (ICC). Scores < 0.20 indicated slight agreement, 0.21-0.40 fair, 0.41-0.60 moderate, 0.61-0.80 substantial,...
518 Background: Pembro received accelerated approval in pts with advanced HCC the second-line setting based on results of KEYNOTE-224 trial. Results a 2 y follow-up analysis efficacy and safety this trial are presented here. Methods: Eligible had histologically confirmed HCC, radiographic progression on/intolerance to sorafenib disease not amenable curative treatment, Child Pugh A, ECOG PS 0-1 BCLC stage C or B. Pts pembro 200 mg IV Q3W for until progression, unacceptable toxicity, consent...
Increasing utilization of primary total knee arthroplasty (TKA) is projected to expand demand for revision TKA. Revision TKAs are procedurally complex and incur high costs on our financially constrained healthcare system. The purpose this study was use a case-control design identify factors predisposing TKA, particularly demographic, clinical perioperative technical factors. We conducted case control investigate patient, surgical associated with greater risk included patients who received...
Objective To determine if adjuvant radiation therapy for patients with pT2N0 oral cavity tongue cancer affects overall survival. Study Design Retrospective cohort study. Setting National Cancer Database. Subjects and Methods Cases diagnosed between 2004 2013 pathologic stage negative surgical margins were extracted from the Data stratified by treatment received, including surgery only + postoperative therapy. Univariate analysis was performed a 2‐sample t test, chi‐square or Fisher exact...
Oxaliplatin-based chemotherapy with a regimen such as FOLFOX or without targeted therapy is standard of care option for advanced colorectal cancer; however, long-term exposure to oxaliplatin associated cumulative toxicity. Growing evidence suggests maintenance less intensive after platinum-based induction can provide continuing benefit reduced We describe the rationale and design Phase III LYNK-003 trial, which will evaluate efficacy safety olaparib bevacizumab compared 5-fluoruracil plus in...
Aims Limited information is available on impairments, activity limitations and participation restrictions in youth with Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic premature aging disease. The purposes were to: (1) describe range of motion (ROM), grip, pinch quadriceps strength, functional balance, walking endurance, gross motor restrictions; (2) evaluate the association between ROM impairments age; (3) Gross Motor Function Measure-88 (GMFM) scores lower extremity (LE) ROM,...
<div>Abstract<p>Therapeutic approaches for clear cell renal carcinoma (ccRCC) remain limited; however, chimeric antigen receptor (CAR) T-cell therapies may offer novel treatment options. CTX130, an allogeneic CD70-targeting CAR product, was developed the of advanced or refractory ccRCC. We report that CTX130 showed favorable preclinical proliferation and cytotoxicity profiles completely regressed RCC xenograft tumors. also results from 16 patients with relapsed/refractory ccRCC...
<div>Abstract<p>Therapeutic approaches for clear cell renal carcinoma (ccRCC) remain limited; however, chimeric antigen receptor (CAR) T-cell therapies may offer novel treatment options. CTX130, an allogeneic CD70-targeting CAR product, was developed the of advanced or refractory ccRCC. We report that CTX130 showed favorable preclinical proliferation and cytotoxicity profiles completely regressed RCC xenograft tumors. also results from 16 patients with relapsed/refractory ccRCC...
<p>Cytokine secretion during CAR T-cell activation upon coculture with CD70+ RCC cells</p>
<p>CTX130 construct</p>
<p>Tumor biopsy CD70 H-scores</p>
<p>CONSORT flow diagram for COBALT-RCC trial design schematic</p>
<p>CTX130 construct</p>
<p>Tumor biopsy CD70 H-scores</p>
<p>COBALT-RCC trial design schematic</p>
<p>Cytokine secretion during CAR T-cell activation upon coculture with CD70+ RCC cells</p>
<p>CONSORT flow diagram for COBALT-RCC trial design schematic</p>