A5035498133- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Management of metastatic bone disease
- Glioma Diagnosis and Treatment
- Radiation Dose and Imaging
- Breast Cancer Treatment Studies
- Spinal Fractures and Fixation Techniques
- Brain Metastases and Treatment
- Spine and Intervertebral Disc Pathology
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Advances in Oncology and Radiotherapy
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Digital Radiography and Breast Imaging
- MRI in cancer diagnosis
- Cancer Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Radiation Detection and Scintillator Technologies
- Tissue Engineering and Regenerative Medicine
- Plant Genetic and Mutation Studies
- Photoacoustic and Ultrasonic Imaging
- Augmented Reality Applications
University Medical Centre Mannheim
2014-2024
Heidelberg University
2014-2024
University Hospital Heidelberg
2014-2024
Medizinische Fakultät Mannheim
2021
University of Mannheim
2019
Loyola University Chicago
2018
Essen University Hospital
2018
McGill University Health Centre
2018
Montreal Neurological Institute and Hospital
2018
Universitätsklinik für Strahlentherapie
2016
The use of IORT as a treatment modality for patients with close or positive margins has increased over the past decade. For situations where flat area (up to 6 cm in diameter) be treated intraoperatively, new applicators superficial miniature X-ray source (INTRABEAM system) were developed. Here we report our evaluation dosimetric characteristics these and their first clinical use. Each surface consists radiation protective metal tube flattening filter, which converts spherical dose...
Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumor in adults. Despite multimodal therapies, almost all GBM recur within a narrow margin around initial resected lesion. Thus, novel therapeutic intensification strategies must target both, population of dispersed cells cavity and postoperative microenvironment. Intraoperative radiotherapy (IORT) pragmatic effective approach to sterilize margins from persistent cells, abrogate post-injury proliferative stimuli...
The median time to recurrence of glioblastoma (GB) following multimodal treatment is ∼7 mo. Nearly all cancers recur locally, suggesting that augmenting local treatments may improve outcomes.To investigate whether intraoperative radiotherapy (IORT) the resection cavity safe and effective.INTRAGO was a phase I/II trial evaluate safety tolerability IORT with 20 40 Gy low-energy photons in addition standard radiochemotherapy (ClinicalTrials.gov ID, NCT02685605). primary endpoint as per...
Abstract Background Radiation induced secondary cancers are a rare but severe late effect after breast conserving therapy. Intraoperative radiotherapy (IORT) is increasingly used during surgery. The purpose of this analysis was to estimate cancer risks IORT compared other modalities (APBI - accelerated partial irradiation, EBRT external beam radiotherapy). Methods Computer-tomography scans an anthropomorphic phantom were acquired with INTRABEAM applicator (diameter 4 cm) in the outer...
Detailed visualization of the cribriform plate is challenging due to its intricate structure. This study investigates how computed tomography (CT) with a novel photon counting (PC) detector enhance compared traditionally used energy-integrated detectors in patients. A total 40 patients were included retrospective analysis, half them undergoing PC CT (Naeotom Alpha Siemens Healthineers, Forchheim, Germany) and other scans using an (Somatom Sensation 64, Siemens, which was visualized temporal...
To generate and validate a source model of miniature X-ray generator (INTRABEAM, Carl Zeiss Surgical, Oberkochen, Germany) for endovaginal TARGeted Intra-operative radioTherapy (TARGIT) brachytherapy Geant4-based Monte Carlo (MC) tool was developed. The used to calculate the accurate relative dose distribution combined with cylindrical applicator which developed treatment.Geometries given materials were implemented in calculation framework. reduce time, phase space files set circular...
The purpose of this work is to develop a virtual source model (VSM) for the 50 kV INTRABEAM® device Monte Carlo (MC) dose calculation. geometry was modelled in Geant4. A phase space file (PSF) computed by simulating interactions monoenergetic primary electrons with target. PSF approximated computing energy spectrum photons PSF. variation photon intensity, mean direction cosine and standard deviation along axis thereafter computed. isotropy used approximate properties on transverse plane....
This study provides an objective comparison of cranial computed tomography (CT) imaging quality and radiation dose between photon counting detectors (PCCTs) energy-integrated (EIDs). We retrospectively analyzed 158 CT scans from 76 patients, employing both detector types on the same individuals to ensure a consistent comparison. Our analysis focused Computed Tomography Dose Index Dose-Length Product together with contrast-to-noise ratio signal-to-noise for brain gray white matter. utilized...
Background: Advances in computed tomography (CT) technology, particularly photon-counting CT (PCCT), are reshaping the possibilities for medical imaging. PCCT spectral imaging enables high-resolution visualization of tissues with material-specific accuracy. This study aims to establish a foundational approach vivo intracranial blood using PCCT, focusing on non-enhanced techniques and capabilities. Methods: We employed detector within framework differentiate between venous arterial blood. Our...
An a priori pharmacokinetic/pharmacodynamic (PK/PD) target of 40% daily time above the MIC (T >MIC; based on MIC(90) 0.06 microg/ml for Streptococcus pyogenes reported in literature) was shown to be achievable phase 1 study 23 children with once-daily (QD) modified-release, multiparticulate formulation amoxicillin (amoxicillin sprinkle). The T >MIC achieved QD sprinkle comparable that four-times-daily (QID) penicillin VK suspension. investigator-blinded, randomized, parallel-group,...
Intraoperative radiotherapy (IORT) using the INTRABEAM(®) system promises a flexible use regarding radiation protection compared to other approaches such as electron treatment or HDR brachytherapy with (192)Ir (60)Co. In this study we dose rate measurements of breast- and Kypho-IORT C-arm fluoroscopy which is needed estimate areas.C-arm fluoroscopy, Kypho-IORTs were performed phantoms (silicon breast bucket water). Dose rates measured at phantom's surface, 30 cm, 100 cm 200 distance. Those...
Despite surgical resection, radiochemotherapy and adjuvant chemotherapy, glioblastoma multiforme (GBM) is still associated with an extremely poor prognosis. As almost all tumors recur locally evidence for a radiation dose-dependent effect on survival exists, intraoperative radiotherapy (IORT) could be approach to avoid tumor cell proliferation between surgery while sparing healthy tissue. The majority of previous studies used forward-scattering electron tubes (resembling radiotherapy, IOERT)...
The spine is the most frequent location of bone metastases. Local treatment aims at palliation pain and, given increased likelihood long-term cancer survival, local control. Kyphoplasty and intraoperative radiotherapy (Kypho-IORT) provided instantaneous relief in 70% patients first day after intervention resulted control rates > 93% 1 year a recently conducted phase I/II trial. To assess its clinical value, we designed III trial which tests Kypho-IORT against widespread standard-of-care,...
Intraoperative radiotherapy (IORT) after surgical resection using a low-kV-X-ray source is proven method used in cancer treatment. However, the shape and size of targeted surface area are limited to available applicators. This can lead nonconformal therefore suboptimal treatment for many patients.A system proposed comprising an X-ray with applicator irradiation mounted on robotic arm. controlled by algorithm designed planning required continuous path, enabling any desired dose...