Marcus Davidsson
A5059039710- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Financial Markets and Investment Strategies
- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- Complex Systems and Time Series Analysis
- Economic theories and models
- Financial Risk and Volatility Modeling
- RNA Interference and Gene Delivery
- Stochastic processes and financial applications
- Risk and Portfolio Optimization
- Monetary Policy and Economic Impact
- RNA regulation and disease
- Fiscal Policy and Economic Growth
- Parkinson's Disease Mechanisms and Treatments
- Reservoir Engineering and Simulation Methods
- Financial Reporting and Valuation Research
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Market Dynamics and Volatility
- Pluripotent Stem Cells Research
- Capital Investment and Risk Analysis
- Modeling, Simulation, and Optimization
- Botulinum Toxin and Related Neurological Disorders
Lund University
2015-2024
Barrow Neurological Institute
2020-2024
Wallenberg Wood Science Center
2021
International Neuromodulation Society
2018
Jönköping University
2012
Newcastle University
2010-2011
University of Newcastle Australia
2011
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2001
CEA Paris-Saclay
2001
Université Libre de Bruxelles
2001
Adeno-associated virus (AAV) capsid modification enables the generation of recombinant vectors with tailored properties and tropism. Most approaches to date depend on random screening, enrichment, serendipity. The approach explored here, called BRAVE (barcoded rational AAV vector evolution), efficient selection engineered structures a large scale using only single screening round in vivo. stands contrast previous methods that require multiple generations enrichment. With approach, each...
A measurement is presented of elastic deeply virtual Compton scattering e++p→e++γ+p at HERA using data taken with the H1 detector. The cross section measured as a function photon virtuality, Q2, and invariant mass, W, γp system, in kinematic range 2<Q2<20GeV2, 30<W<120GeV |t|<1GeV2, where t squared momentum transfer to proton. compared QCD based calculations.
A measurement of the derivative (d ln F_2 / d lnx)_(Q^2)= -lambda(x,Q^2) proton structure function is presented in low x domain deeply inelastic positron-proton scattering. For 5*10^(-5)<=x<=0.01 and Q^2>=1.5 GeV^2, lambda(x,Q^2) found to be independent increase linearly with ln(Q^2).
Abstract Recombinant adeno‐associated virus (rAAV) is a mammalian that has been altered to be used as gene delivery vehicle. Several changes the viral genome have made them replication deficient so this aspect of infection cycle under full control experimenter, while maintaining expression machinery. Over last decades, rAAVs become gold standard for studying in vivo function and are especially favorable transfer central nervous system. AAVs proven safe provide stable over long period time....
The inclusive production of D∗±(2010) mesons in deep-inelastic scattering is studied with the H1 detector at HERA. In kinematic region 1<Q2<100 GeV2 and 0.05<y<0.7 an e+p cross section for D∗± meson 8.50±0.42(stat.)+1.21−1.00(syst.) nb measured visible range ptD∗>1.5 GeV |ηD∗|<1.5. Single double differential sections are compared to perturbative QCD calculations two different evolution schemes. charm contribution proton structure, F2c(x,Q2), determined by extrapolating full phase space. This...
Background: Preclinical rodent models for Parkinson’s disease (PD) based on viral human alpha-synuclein (h-αSyn) overexpression recapitulate some of the pathological hallmarks as it presents in humans, such progressive cell loss and additional synucleinopathy cortical subcortical structures. Recent studies have combined vector-based wild-type αSyn with sequential or simultaneous inoculation preformed fibrils (PFFs) derived from αSyn. Objective: The goal study was to investigate whether...
Synucleinopathies, characterized by intracellular aggregation of α-synuclein protein, share a number features in pathology and disease progression. However, the vulnerable cell population differs significantly between disorders, despite being caused same protein. While vulnerability dopamine cells substantia nigra to over-expression, its link Parkinson's disease, is well studied, animal models recapitulating cortical degeneration dementia with Lewy-bodies (DLB) are much less mature. The aim...
The diffractive photoproduction of J/psi mesons is measured with the H1 detector at ep collider HERA using an integrated luminosity 78 pb^-1. differential cross section d sigma(gamma p -> Y) / t studied in range 2 < |t| 30 GeV^2, where square four-momentum transferred proton vertex. also presented as a function photon-proton centre-of-mass energy W three intervals, spanning 50 200 GeV. A fast rise observed for each and slope effective linear Pomeron trajectory to be alpha^\prime= -0.0135 \pm...
Abstract Detailed characterization and mapping of oligonucleotide function in vivo is generally a very time consuming effort that only allows for hypothesis driven subsampling the full sequence to be analysed. Recent advances deep sequencing together with highly efficient parallel synthesis cloning techniques have, however, opened up entirely new ways map genetic . Here we present novel, optimized protocol generation universally applicable, barcode labelled, plasmid libraries. The libraries...
Abstract Adeno Associated Virus (AAV)-mediated gene expression in the brain is widely applied preclinical setting to investigate therapeutic potential of specific molecular targets, characterize various cellular functions, and model central nervous system (CNS) diseases. In applications clinical setting, therapy offers several advantages over traditional pharmacological based therapies, including ability directly manipulate disease mechanisms, selectively target disease-afflicted regions,...
1 million people are predicted to get infected with Lyme disease in the USA 2018. Given same incidence rate of Europe as USA, then 2.4 will In by 2050, 55.7 (12% population) have been disease. 134.9 (17% Most these infections will, unfortunately, become chronic. The estimated treatment cost for acute and chronic 2018 is somewhere between 4.8 billion USD 9.6 10.1 EUR 20.1 EUR. If governments do not finance IV antibiotics disease, government want minimize future costs maximize revenues, they...
A search for events with a high-energy isolated electron or muon and missing transverse momentum has been performed at the electron–proton collider HERA using an integrated luminosity of 13.6 pb−1 in e−p scattering 104.7 e+p scattering. Within Standard Model such are expected to be mainly due W boson production subsequent leptonic decay. In interactions one event is observed channel none channel, consistent expectation Model. data total 18 seen channels compared 12.4±1.7 dominated by...
Background: In addition to classical neurological symptoms, Huntington's disease (HD) is complicated by peripheral pathology, including progressive skeletal muscle wasting, and common gene expression changes have been shown in HD mice
In the last decades different preclinical animal models of Parkinson's disease (PD) have been generated, aiming to mimic progressive neuronal loss midbrain dopaminergic (DA) cells as well motor and non-motor impairment. Among all available models, AAV-based human alpha-synuclein (h-aSYN) overexpression are promising tools for investigation progression therapeutic interventions.The goal with this work was characterise impairment in domains following nigrostriatal h-aSYN correlate behavioural...