A5039406239- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Plant Gene Expression Analysis
- Sirtuins and Resveratrol in Medicine
- Postharvest Quality and Shelf Life Management
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Diabetic Foot Ulcer Assessment and Management
- Calpain Protease Function and Regulation
- Coronary Interventions and Diagnostics
- Metabolism, Diabetes, and Cancer
- Plant Physiology and Cultivation Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Angiogenesis and VEGF in Cancer
- Nitric Oxide and Endothelin Effects
- Plant Reproductive Biology
- Protease and Inhibitor Mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Agroforestry and silvopastoral systems
- Supercapacitor Materials and Fabrication
- Gestational Diabetes Research and Management
- Catalysis for Biomass Conversion
- Genetic and Environmental Crop Studies
- RNA regulation and disease
Luliang University
2023-2025
University of Toronto
2008-2021
Chongqing University
2016-2018
Canada Research Chairs
2013
Czech Academy of Sciences, Institute of Physiology
2010
Histone deacetylation is one of the well characterized post-translational modifications related to transcriptional repression in eukaryotes. The process histone achieved by deacetylases (HDACs). Over last decade, substantial advances our understanding mechanism fruit ripening have been achieved, but role HDACs this has not elucidated. In study, an RNA interference (RNAi) expression vector targeting SlHDA1 was constructed and transformed into tomato plants. Shorter time decreased storability...
ABSTRACT Plants are often subjected to various abiotic stresses in the natural environment, seriously influencing plant growth and development even leading death, but potential mechanisms remain unknown. In this study, we investigated role of SlHDT1 response such as low temperature, high temperature waterlogging. Silencing tomato resulted reduced tolerance stress, stress waterlogging ‐RNAi transgenic plants. Compared with wild‐type (WT) plants, lines exhibited more severe leaf wilting under...
Dietary protein restriction during pregnancy and lactation in rats impairs β-cell function mass neonates leads to glucose intolerance adult offspring. Maternal taurine (Tau) supplementation restores neonates, but its long-term effects are unclear. The prevention of postnatal catch-up growth has been suggested improve tolerance offspring low-protein (LP)-fed mothers. objective this study was examine the relative contribution dysfunction insulin resistance impaired 130-day-old rat LP-fed...
Mediator complex, a conserved multi-protein, is necessary for controlling RNA polymerase II (Pol II) transcription in eukaryotes. Given little known about them tomato, tomato subunit 18 gene was isolated and named SlMED18. To further explore the function of SlMED18, transgenic plants targeting SlMED18 by RNAi-mediated silencing were generated. The SlMED18-RNAi lines exhibited multiple developmental defects, including smaller size slower growth rate plant significantly compound leaves....
A hyperglycemic and hyperinsulinemic environment characteristic of type 2 diabetes causes insulin resistance. In adipocytes, defects in both sensitivity maximum response glucose transport have been demonstrated. To investigate the molecular mechanisms, freshly isolated rat adipocytes were incubated control (5.6 mM glucose, no insulin) high (20 mM)/high (100 nM) (HG/HI) for 18 hours to induce Insulin-resistant manifested decreased uptake associated with receptor substrate (IRS)-1 Tyr...
<i>Background/Aims:</i> In our previous studies, rats on insulin treatment (5 U/day) and oral glucose to avoid hypoglycemia had reduced neointimal growth after arterial injury. However, plasma in the insulin-treated was lower than normal effect of remained undetermined. this study, effects normoglycemic hyperinsulinemia or sucrose were investigated same model. <i>Methods:</i> Rats divided into 6 groups: (1) control implants tap water; (2) + i.p. any lowering; (3) (4...
In vitro, insulin has both growth-promoting and vasculoprotective effects. vivo<i>,</i> the effect of is mainly protective. Insulin treatment (3 U/day) decreases smooth muscle cell (SMC) migration neointimal growth after carotid angioplasty in normal rats maintained at normoglycemia by oral glucose. SMC requires limited proteolysis extracellular matrix, which mediated matrix metalloproteinases (MMPs). this study, we investigated effects normoglycemic hyperinsulinemia on MMP...
Background: Insulin exerts vasculoprotective effects on endothelial cells (ECs) and growth-promoting vascular smooth muscle (SMCs) in vitro, suppresses neointimal growth vivo. Here we determined the role of ECs SMCs effect insulin growth. Methods: Mice with transgene CreER T2 under control EC-specific Tie2 (Tie2-Cre) or SMC-specific myosin heavy chain promoter/enhancer (SMMHC-Cre) littermate controls were crossbred mice carrying a loxP-flanked receptor (IR) gene. After -loxP-mediated...
We have shown that both insulin and resveratrol (RSV) decrease neointimal hyperplasia in chow-fed rodents via mechanisms are part overlapping involve the activation of endothelial nitric oxide synthase (eNOS). However, this vasculoprotective effect is abolished high-fat-fed insulin-resistant rats. Since RSV, addition to increasing sensitivity, can activate eNOS pathways independent signaling, such as sirtuin 1 (SIRT1) AMP-activated kinase (AMPK), we speculated unlike insulin, RSV would be...
Anti-mitogenic agents currently used to prevent restenosis in drug-eluting stents delay re-endothelialization. Delayed re-endothelialization is now considered as the main cause of late stent thrombosis with stents, which emphasizes need for new treatments. We have shown that systemic insulin treatment decreases neointimal growth and accelerates after arterial injury a rat model restenosis. However, cannot be given non-diabetic individuals because risk hypoglycemia. Thus, we investigated...