A5058871668- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Orthopedic Infections and Treatments
- Sarcoma Diagnosis and Treatment
- Bone fractures and treatments
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Bone health and osteoporosis research
- Dental Implant Techniques and Outcomes
- Bone Tumor Diagnosis and Treatments
Lund University
2022-2024
National Postdoctoral Association
2022
Efficient systemic pharmacological treatment of solid tumors is hampered by inadequate tumor concentration cytostatics necessitating development smart local drug delivery systems. To overcome this, we demonstrate that doxorubicin (DOX), a cornerstone used for osteosarcoma treatment, shows reversible accretion to hydroxyapatite (HA) both nano (nHA) and micro (mHA) size. nHA particles functionalized with DOX get engulfed in the lysosome cells where acidic microenvironment causes disruption...
Despite the glimmer of hope provided by discovery and commercialization bone morphogenetic protein-2 (BMP-2) as a graft substitute, side effects related to use supraphysiological doses have hindered its clinical usage. In this study, we compared osteoinductive potential BMP-2 homodimer with heterodimer BMP-2/7, both delivered via collagen-hydroxyapatite (CHA) scaffold delivery system, aim reduce overall therapeutic BMP associated side-effects. We first show that incorporation hydroxyapatite...
Bone mineralization involves a complex orchestration of physico-chemical responses from the organism. Despite extensive studies, detailed mechanisms remain to be elucidated. This study aims characterize bone using an in-vivo long fracture healing model in rat. The spatio-temporal distribution relevant elements was correlated deposition and maturation hydroxyapatite presence matrix remodeling compounds (MMP-13). Multi-scale measurements indicated that (i) zinc is required for both initial...
There is a lack of biomaterial-based carriers for the local delivery rifampicin (RIF), one cornerstone second defence antibiotics bone infections. RIF also known causing rapid development antibiotic resistance when given as monotherapy. This in vitro study evaluated clinically used biphasic calcium sulphate/hydroxyapatite (CaS/HA) biomaterial carrier dual with vancomycin (VAN) or gentamicin (GEN).The CaS/HA composites containing RIF/GEN/VAN, either alone combination, were first prepared and...
Osteosarcoma treatment comprises pre-surgical chemotherapy followed by radical surgery and further cycles, but the prognosis has been far from satisfactory. No new drugs or modalities have developed for clinical use in last four decades. We describe a nano-hydroxyapatite (HA)-based local drug delivery platform of doxorubicin (DOX), cornerstone osteosarcoma treatment. The efficacy system was evaluated an orthotopic human xenograft proximal tibia mice. After tumor development, surgically...