A5032457439- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Pneumonia and Respiratory Infections
- Malaria Research and Control
- Vaccine Coverage and Hesitancy
- Viral Infections and Immunology Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Infections and Vaccines
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Respiratory viral infections research
- HIV Research and Treatment
- Muscle and Compartmental Disorders
- Escherichia coli research studies
- Parasites and Host Interactions
- Salmonella and Campylobacter epidemiology
- Cardiovascular Effects of Exercise
- HIV/AIDS oral health manifestations
- Parasitic Infections and Diagnostics
- Herpesvirus Infections and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Travel-related health issues
- Viral Infections and Outbreaks Research
- HIV/AIDS Research and Interventions
Mahidol Oxford Tropical Medicine Research Unit
2015-2024
Mahidol University
2015-2024
Hand, foot, and mouth disease (HFMD) is a contagious childhood illness annually affects millions of children aged less than 5 years across the Asia–Pacific region. HFMD transmission mainly occurs through direct contact (person-to-person) indirect with contaminated surfaces objects. Therefore, public health measures to reduce spread in kindergartens daycare centers are essential. Based on guidelines by Department Disease Control, school closure policy for outbreaks wherein every Thailand must...
Most cases of dengue virus infection are mild, but severe can be fatal. Therefore, identification factors associated with severity is essential to improve patient outcomes and reduce mortality. The objective this study was assess associations between nutritional status among Thai children adolescents. This retrospective cross-sectional based on the medical records 355 patients treated at Hospital for Tropical Disease (Bangkok, Thailand) from 2017 2019. Subjects were aged less than 18 years...
Abstract Background Dengue disease is caused by dengue virus, which transmitted Aedes mosquitoes in tropical and subtropical regions worldwide. Although most infected individuals have benign febrile illness or no apparent symptoms, a small percentage develop severe dengue, potentially fatal condition that occurs after stage. Many studies identified factors predicting severity among different populations time courses. To help find practical approaches applicable remote settings, we focused on...
Inactivated mouse-brain-derived Japanese encephalitis vaccine has a worrisome safety profile and the live attenuated is unsuitable in immunodeficiency. This study aimed to evaluate immunogenicity of an inactivated chromatographically purified Vero-cell-derived JE (CVI-JE, Beijing P-3 strain) children. 152 healthy Thai children, with average (SD) age 14.4 (3.8) months, received 3 doses CVI-JE on days 0, 7-28, one year. Homologous neutralizing antibody titers (NT) were measured. All subjects...
Background The WHO 'Global Strategy for Dengue Prevention and Control, 2012–2020' addresses the growing need treatment of dengue, targets a 25% reduction in morbidity 50% mortality (using 2010 estimates as baseline). Achieving these goals requires future dengue prevention strategies that will employ both potential vaccines sustainable vector-control measures. Maternally transferred antibody is an important factor determining optimal age vaccination. Objectives To estimate seroprevalence...
Immunization is a core component of the human right to health. However, accessibility Expanded Program on (EPI) might be difficult among migrant children. This study aims assess vaccination coverage children under mobile immunization program, initiated by Thai government in 2014. A cross-sectional, mixed-methods was conducted five districts along Thailand–Myanmar border during July–December 2018. The history their first year life obtained. Focus group discussions were stakeholders explore...
Background Dengue is a major public health problem in Thailand, but data are often focused on certain dengue-endemic areas. Methods: To better understand dengue epidemiology and clinical characteristics fever surveillance study was conducted among patients aged 1–55 years, who presented with non-localized febrile illness at Bang Phae Community Hospital Ratchaburi province, Thailand from October 2011 to September 2016. Results Among 951 episodes, 130 were dengue-confirmed. Individuals 10–14...
The recombinant, live, attenuated, tetravalent dengue vaccine CYD-TDV has shown efficacy against all four serotypes. In this exploratory study (CYD59, NCT02827162), we evaluated potential associations of host human leukocyte antigen (HLA) alleles with antibody responses, efficacy, and virologically-confirmed (VCD) cases. Children 4-11 years old, who previously completed a phase 2b in single center Thailand, were included the study. Genotyping HLA class I II loci was performed by...
The seroprevalence of toxoplasma antibodies in pregnant women and the prevalence congenital infection differ widely between countries. A few cases toxoplasmosis diagnosed after neonatal period, with long-term sequelae, have been reported Thailand. No data on documented no screening for during pregnancy has undertaken
Abstract Background Undernutrition has been shown to be associated with various infectious diseases. However, the recent improvement in nutritional status and management for diseases worldwide necessitates re-evaluation of this association. Methods A retrospective study was conducted children aged <14 years old dengue, malaria or acute diarrhea who visited were admitted Tha Song Yang hospital, near Thai–Myanmar border. Results Most patients had mild disease most undernourishment mild....
<br><b>Objective:</b> To investigate the long-term safety of a tetravalent dengue vaccine (CYD-TDV) in children phase <b>Π</b> b follow-up study Thailand.<br><b>Methods:</b> In study, aged 4-11 years were randomized (2:1) to receive three injections CYD-TDV or serve as control at 6-month intervals, with 25 months’ active (active phase). This was an additional four-year passive surveillance for hospitalized virologically-confirmed (VCD; hospital Cases VCD, severe vaccine-related serious...
Hand, foot, and mouth disease (HFMD) is a contagious mainly occurring in young children, outbreaks commonly occur among children the Asia–Pacific region including Thailand. Moreover, World Health Organization (WHO) monitors HFMD Western Pacific to detect other significant events by Regional Event Based Surveillance System. caused group of enteroviruses (EVs) transmitted through direct contact (person person) indirect with contaminated objects (surface-to-hand). However, few studies have...
Dengue infection is a well-known tropical disease that has become global health issue. The clinical characteristics of dengue range from asymptomatic to severe, which can involve multiple organs and challenge management. Rhabdomyolysis in rare condition described children adolescents. Herein, we present the case young adolescent with autism spectrum disorder who had virus serotype 1 complicated by rhabdomyolysis, was not detected based on its typical manifestations. recognized as one...
Japanese encephalitis is the main cause of viral in Asia. In a previous single-arm vaccine trial, an inactivated chromatographically purified Vero cell (CVI-JE; JEVACTM) was safe and immunogenic 152 Thai children aged 1-3 years receiving 2-dose primary immunization booster dose 1 year later. We conducted 5-year follow-up assessment persistence immune response 144 remaining this cohort after first dose. Immunity assessed by 50% plaque reduction neutralization test annually for up to 5...
Streptococcus pneumoniae (S. pneumoniae) is the major pathogen that causes health problems worldwide. Invasive disease includes meningitis, bacteremia with or without focus and pneumonia. It morbidity mortality, especially in children. In Thailand, no relevant study was done to estimate exact incidence of invasive pneumococcal diseases. Serotypes, children diseases, differ slightly by age; less than five years old: serotype 23F, 6B, 14, 9V, 19F, more 4, while most frequent serotypes...
Background: Streptococcus pneumoniae, an important pathogen worldwide, causes a wide range of diseases mostly in young children and older adults. The heptavalent pneumococcal conjugate vaccine (PCV7) that is composed seven serotypes (4, 6B, 9V, 14, 18C, 19F, 23F), was most prevalent Thailand during this vaccination study. Aim: To determine immune responses to PCV7 among Thai with high risk for invasive disease whether had specific antibody related serotype 19A. Methods: antibody-mediated...