Apart from other risk factors, chronic inflammation is also associated with the onset of Prostate Cancer (PCa), wherein pathogen infection and tissue microbiome dysbiosis are known to play a major role in both inflammatory response cancer development. However, except for few studies, link between microbes PCa remained poorly understood. To explore potential signature Indian patients, we investigated differential compositions commensal bacteria among patients benign prostatic hyperplasia...

Prevalence of gestational diabetes mellitus (GDM) may vary across a country like India. Risk factors and disease-pathogenesis were also not fully elucidated. This study aimed to examine prevalence GDM among pregnant women visiting antenatal clinic tertiary-care hospital Kolkata, India; possible mechanism disease pathogenesis potency associated parameters as biomarkers explored.735 screened for according DIPSI (Diabetes in Pregnancy Study Group India) guideline risk-factors analyzed....

CDX2 is a caudal homeobox gene essential for intestinal differentiation and specifically expressed in colorectal adenocarcinomas. Its role carcinogenesis not fully elucidated.To study the expression pattern of Ki-67 different grades adenocarcinomas to observe relationship their staining patterns various tumor stages look correlation if any, between labeling index (Ki-67 LI) expression.A total 74 cases were enrolled. Detailed clinical profile, peroperative findings, histological grading...

Rhabdomyosarcoma (RMS) is one of the common malignant tumors in pediatric age group. There only a single case report primary renal alveolar RMS. Fine needle aspiration (FNA) findings RMS has not been reported so far. Hence we present an unusual kidney. An 11 year old boy presented with abdominal mass. On FNA diagnosis undifferentiated sarcoma and anaplastic Wilms tumor were considered. The was resected showed histopathological features rhabdomyosarcoma. He developed multiple bony metastases...

Pap-smears-based cytology and human papilloma virus testing have their own limitations in detecting cervical precancerous lesions, still need further standardization. Co-expression of p16ink4a Ki-67 can be used as additional biomarker.To study the role liquid-based dual immunostaining for p16/Ki-67 predicting presence significant lesion cases mild cytological atypia.A prospective, cross-sectional was performed Department Pathology, collaboration with Obstetrics Gynecology over 15 months...

Lewandowsky and Lutz dysplasia, also known as epidermodysplasia verruciformis (EV), is an inherited disorder in which there widespread persistent infection with human papilloma virus, defect cell-mediated immunity propensity for malignant transformation. Differential clinical histopathologic evolutions of lesions two cases familial EV are compared discussed detail. Cases were followed up 7 years. Detailed history, features investigations, including skin biopsy from different sites at times,...

AbstractThe genetic etiology of gestational diabetes mellitus (GDM) was suggested to overlap with type-2 diabetes(T2D). Transcription factor 7-like 2 (TCF7L2) and Proprotein Convertase Subtilisin/Kexin type (PCSK2) are T2D susceptibility genes the insulin synthesis/processing pathway. We analyzed associations TCF7L2 PCSK2 variants GDM risk evaluated their potential impact on impaired processing in an eastern Indian population. The study included 114 (case) 228 non-GDM pregnant women...

Inflammatory myofibroblastic tumor is a of intermediate grade with low rate metastasis. The often mimics malignancy. There sparse literature available describing the cytological findings this rare condition. It presents in infancy and childhood as an intra‐abdominal mass. Here, we describe three cases inflammatory infants aged 10 months, 4 15 respectively. While first two are fine needle aspiration cytology (FNAC) smears, third case that intraoperative imprint cytology. All smears showed...

Neuroblastoma, ganglioneuroblastoma and ganglioneuroma atumors arising from the neural crest cells. Ganglioneuroma is considered as most mature amongst three usually has no metastatic potential. Spontaneous maturation of neuroblastoma into is, however, quite well-known. Here, we present a case an 8-year-old girl child with evidence metastasis lymph node.

Abstract Objective: To evaluate the role of exponential apparent diffusion coefficient (ADC) as a tool for differentiating benign and malignant breast lesions. Patients Methods: This prospective observational study included 88 lesions in 77 patients (between 18 85 years age) who underwent 3T magnetic resonance imaging (MRI) including diffusion-weighted (DWI) using b-values 0 800 s/mm2 before biopsy. Mean ADC obtained from DWI were compared. Receiver operating characteristics (ROC) curve...

<br>Polyarteritis nodosa (PAN), a systemic necrotizing vasculitis with multiorgan development, is generally restricted to the medium-sized muscular arteries. The varied initial clinical presentations of PAN can lead delayed diagnosis. We present case middle-aged male patient who presented an acute onset right-sided testicular pain as symptom ischemic changes on ultrasonogram, thereby requiring orchiectomy. This was reported be tubercular epididymo-orchitis. On review, biopsy revealed...

Role of squash cytology in intraoperative diagnosis central nervous system lesions has been well established. Intraoperative is especially important paediatric CNS as decision regarding gross total resection or near subtotal crucial and radiotherapy chemotherapy are best avoided this age group. The aim study was to evaluate the utility group assess its diagnostic accuracy, sensitivity, specificity, positive predictive value negative value.A prospective conducted on 42 patients with...

Retiform hemangioendothelioma is a rare vascular neoplasm of intermediate grade, the diagnosis which can be challenging. We report case 35-year-old man with swelling in postauricular region. He had undergone FNAC revealed blood only. Microscopic examination showed narrow, arborizing, channels resembling normal rete testis. Evidence mitoses or cytological atypia were lacking. Immunohistochemistry diffuse and strong staining for CD34 along CD31 positivity. Immunostains D240 GLUT1 negative. A...

Gastrointestinal polyps commonly affect the pediatric population. The commoner variety amongst these is solitary rectal polyp. Juvenile polyposis coli (JPC) rare, characterized by multiple occurring throughout gut.The role of cyclooxygenase-2 (COX-2) has been implicated in gastrointestinal tumorigenesis. We aimed to look at clinicopathological spectrum vs juvenile and compare their differences expression COX-2 p53.We studied 38 from eight cases JPC, collected over past 10 years along with 40...

Numerous biomarkers have been investigated for the diagnosis and follow-up of patients with bladder cancer, but none has achieved desirable acceptability. In search biomarkers, minichromosome maintenance protein 2 (MCM2), a cell cycle regulatory protein, was preliminary results were promising. Hence, we conducted study to investigate role immunocytochemical (ICC) detection MCM2 in voided urinary samples cancer an Indian population.A prospective comparative observational performed. One...

<br>A 40-day-old baby presented with prolonged fever, petechial spots, hepatosplenomegaly, generalized lymphadenopathy, and pancytopenia. Investigations revealed positive anti-dengue virus IgM antibody, bone marrow examination demonstrated the presence of hemophagocytes. The diagnosis hemophagocytic lymphohistiocytosis (HLH) was made according to HLH-2004 guidelines. HLH associated primary dengue in an infant who symptomatic from neonatal age has hitherto not been reported literature.