A5069542731- Ion Channels and Receptors
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Cardiac electrophysiology and arrhythmias
- Cellular transport and secretion
- Connexins and lens biology
- Innovations in Medical Education
- Pancreatic function and diabetes
- Grit, Self-Efficacy, and Motivation
- Online and Blended Learning
- Animal Genetics and Reproduction
- Global Health Workforce Issues
- Pluripotent Stem Cells Research
- Mobile Learning in Education
- Innovative Teaching Methods
- Medical Education and Admissions
- Photosynthetic Processes and Mechanisms
- Online Learning and Analytics
- ATP Synthase and ATPases Research
- Emotional Intelligence and Performance
- Cellular Mechanics and Interactions
- Science, Research, and Medicine
- Healthcare Education and Workforce Issues
King Saud bin Abdulaziz University for Health Sciences
2015-2024
King Abdullah International Medical Research Center
2019-2023
National Guard Health Affairs
2019
King Abdulaziz University
2019
University of Leeds
2013-2017
Diabetic stress increases the production of reactive oxygen species (ROS), leading to mitochondrial fragmentation and dysfunction. We hypothesized that ROS-sensitive TRPM2 channels mediated diabetic stress-induced fragmentation. found chemical inhibitors, RNAi silencing, genetic knockout abolished ability high glucose cause fission in endothelial cells, a cell type is particularly vulnerable stress. Similar glucose, increasing ROS cells by applying H2O2 induced fission. Ca2+ entered through...
Cell migration is a fundamental feature of tumour metastasis and angiogenesis. It regulated by variety signalling molecules including H2O2 Ca(2+) Here, we asked whether the H2O2-sensitive transient receptor potential melastatin 2 (TRPM2) channel serves as molecular link between H2O2-mediated activation TRPM2 channels induced filopodia formation, loss actin stress fibres disassembly focal adhesions, leading to increased HeLa prostate cancer (PC)-3 cells. Activation channels, however, caused...
Reactive oxygen species (ROS) can cause pancreatic β-cell death by activating transient receptor potential (melastatin) 2 (TRPM2) channels. Cell has been attributed to the ability of these channels raise cytosolic Ca2+. Recent studies however revealed that TRPM2 also conduct Zn2+, but physiological relevance this property is enigmatic. Given Zn2+ cytotoxic, we asked whether permeate sufficient affect cell viability. To address this, used insulin secreting (INS1) line, human embryonic kidney...
The hERG potassium channel is critical for repolarisation of the cardiac action potential. Reduced expression at plasma membrane, whether caused by hereditary mutations or drugs, results in long QT syndrome and increases risk ventricular arrhythmias. Thus, it fundamental importance to understand how density this membrane regulated. We used antibodies an extracellular native engineered epitope, conjunction with immunofluorescence ELISA, investigate mechanism endocytosis recombinant cells...
Cell migration is a fundamental feature of tumour metastasis and angiogenesis. It regulated by variety signalling molecules including H2O2 Ca(2+) Here, we asked whether the H2O2-sensitive transient receptor potential melastatin 2 (TRPM2) channel serves as molecular link between H2O2-mediated activation TRPM2 channels induced filopodia formation, loss actin stress fibres disassembly focal adhesions, leading to increased HeLa prostate cancer (PC)-3 cells. Activation channels, however, caused...
<h3>Objectives:</h3> To assess the perception and expectation of students about quality educational services identify gap in services. <h3>Methods:</h3> This cross-sectional study was conducted at King Saud bin Abdulaziz University for Health Sciences (KSAU-HS) colleges across all regions (Riyadh, Jeddah, Al-Ahsa) within one academic year (September 2017- April 2018). The difference between students’ perceptions expectations calculated to these 2 opinions. <h3>Results:</h3> A total 416...
Background The most common teaching method in science is the lecture-based approach. E-learning one of advanced methodologies that have gained attention recent decades. It was hypothesized intervention e-learning improved students' scores and satisfaction biology classes. purpose this study to determine if combined with traditional learning methods lectures would improve unified Methodology design a quasi-experimental This conducted at College Science Health Professions Jeddah, King Saud bin...
In recent years, much attention is given by education researchers and accrediting bodies to the role of non-cognitive ability on academic success potential employment. This research paper aimed explore combined influence cognitive predictors in forecasting performance students, measured university grade point average (GPA), at end second year Saudi Arabia. Results indicate that key GPA were achievement test/general aptitude test (AAT/GAT) scores High School (HSGPA). Pre-university abilities...
KEYWORDS: calciumdiabetesfatty acidmitochondrial dynamicsobesityoxidative stresspancreatic β-cell deathreactive oxygen speciesTRPM2zinc
In age-related diseases, rise in intracellular reactive oxygen species (ROS) causes fragmentation of mitochondrial network. Our recent study demonstrated that ROS activation TRPM2 (transient receptor potential melastatin-2) channels triggers lysosomal Zn2+ release that, turn, fragmentation. The findings provide new mechanistic insights may have therapeutic implications.
Background: To investigate the development of two-cell mouse embryos in vitro at different external environment factors (osmolarity) and demonstrate if embryo early stage is sensitive to osmotic stress or not.
 Methods: A total 173 were collected during period January 2018 until July 2018. One NMRI male was caged with female mice CD1 for natural mating. Th e flushed from oviduct after 24 hours. mating confirmed by presence a plug vagina (whitish gelatine substance vagina) next day....