A5069102647- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- Chronic Kidney Disease and Diabetes
- Spinal Cord Injury Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Renal Diseases and Glomerulopathies
- Pancreatitis Pathology and Treatment
- Venous Thromboembolism Diagnosis and Management
- Neurological Disorders and Treatments
- Bone health and osteoporosis research
- Morinda citrifolia extract uses
- Spinal Hematomas and Complications
- Ferroptosis and cancer prognosis
- Ginkgo biloba and Cashew Applications
- Rough Sets and Fuzzy Logic
- Digital Media Forensic Detection
- Appendicitis Diagnosis and Management
- Diverse Scientific Research Studies
- Generative Adversarial Networks and Image Synthesis
- Meta-analysis and systematic reviews
China-Japan Friendship Hospital
2024-2025
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Peking University
2024
Shanxi Agricultural University
2022-2023
Shandong University
2023
Jiangnan University
2023
Nanjing University of Science and Technology
2023
Hebei Medical University
2021-2022
Xi'an Jiaotong University
2022
<h3>Objective</h3> To determine the effect of remote ischemic postconditioning (RIPC) on patients with acute stroke (AIS) undergoing IV thrombolysis (IVT). <h3>Methods</h3> A single-center randomized controlled trial was performed AIS receiving IVT. Patients in RIPC group were administered treatment (after IVT) during hospitalization. The primary endpoint a score 0 or 1 modified Rankin scale (mRS) at day 90. safety, tolerability, and neuroprotection biomarkers associated also evaluated....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes disease 2019 (COVID-19), which can induce multisystem disease. Human angiotensin-converting enzyme (ACE2) widely expressing in arterial and venous endothelial cells smooth muscle has been identified as a functional receptor for SARS-CoV-2. Dysfunction of ACE2 leads to abnormal activation the renin-angiotensin system systemic endotheliitis that may relate coagulation sepsis. Meanwhile, innate immune response inflammation...
Abstract Background Diabetic kidney disease (DKD) is a primary microvascular complication of diabetes with limited therapeutic effects. Delving into the pathogenic mechanisms DKD and identifying new targets crucial. Emerging studies reveal implication ferroptosis immune dysregulation in pathogenesis DKD, however, precise relationship between them remains not fully elucidated. Investigating their interplay pivotal to unraveling diabetic disease, offering insights crucial for targeted...
<title>Abstract</title> Purpose This study aims to evaluate the causal relationship between chronic kidney disease (CKD) and osteoporosis using two-sample Mendelian randomization (MR) drug-target MR, investigate potential association TNFRSF11A estimated glomerular filtration rate (eGFR). Methods The utilized single nucleotide polymorphisms (SNPs) associated with eGFR urinary albumin-to-creatinine ratio (UACR) identified by Chronic Kidney Disease Genetics Consortium, as well SNPs related...
Muscle development is closely related to meat quality and production. CircRNAs, with a closed-ring structure, have been identified as key regulator of muscle development. However, the roles mechanisms circRNAs in myogenesis are largely unknown. Hence, order unravel functions myogenesis, present study explored circRNA profiling skeletal between Mashen Large White pigs. The results showed that total 362 circRNAs, which included circIGF1R, were differentially expressed two pig breeds....
The identification of non-invasive biomarkers for the detection renal cell carcinoma (RCC) in early-stage patients may help improve disease outcome. Certain long non-coding RNAs (lncRNAs) have been reported to be possible diagnosis and prognosis cancer. Here, we examined suitability lncRNA LINC00887 as a potential biomarker RCC because its expression has shown elevated tissue versus normal Gene Expression Profiling Interactive Analysis (GEPIA) database. We found that is significantly...
The growth and development of skeletal muscle is regulated by many factors, recent studies have shown that circular RNAs (circRNAs) can participate in this process. model porcine injury was constructed to search for circRNAs regulate the pigs. Using whole-transcriptome sequencing bioinformatics analysis, a novel circRNA (circCSDE1) screened out, which highly expressed muscle. Functional C2C12 cells demonstrated circCSDE1 could promote proliferation inhibit myoblast differentiation, while...
Abstract Migraine is a medical condition with severe recursive headache. The activation of the trigeminovascular system an important mechanism. neuropeptide calcitonin gene-related peptide (CGRP) plays crucial role in pathogenesis migraine. Several other neuropeptides are also involved; however, their roles migraine remain unclear. In this study, using rat model induced by electrical stimulation trigeminal ganglia (TG) and improved version repeated stimulation, we observed dynamic changes...
This study presents proof of concept for designing a novel HIV-1 covalent inhibitor targeting the highly conserved Tyr318 in non-nucleoside reverse transcriptase inhibitors binding pocket to improve drug resistance profiles. The target ZA-2 with fluorosulfate warhead structure was found be potent (EC50 = 11-246 nM) against IIIB and panel NNRTIs-resistant strains, being far superior those NVP EFV. Moreover, demonstrated lower cytotoxicity (CC50 125 µM). In inhibitory assay, exhibited an IC50...
Abstract Fat deposition is critical to pork quality. However, the mechanism of fat remains be elucidated. Circular RNAs (circRNAs) are ideal biomarkers and involved in adipogenesis. Here, we investigated effect circHOMER1 on porcine adipogenesis vitro vivo. Western blotting, Oil red O staining, HE staining were used assess function The results showed that inhibited adipogenic differentiation preadipocytes suppressed mice. Dual‐luciferase reporter gene, RIP, pull‐down assays demonstrated...
Stable Diffusion (SD) customization approaches enable users to personalize SD model outputs, greatly enhancing the flexibility and diversity of AI art. However, they also allow individuals plagiarize specific styles or subjects from copyrighted images, which raises significant concerns about potential copyright infringement. To address this issue, we propose an invisible data-free universal adversarial watermark (DUAW), aiming protect a myriad images different across various versions models....
Autophagy is a main defense strategy by which infected host cells can virtually induce the killing of parasite, including Toxoplasma gondii. However, regulatory mechanisms autophagy in T. gondii-infected nonhematopoietic are still unknown. Emerging evidence indicates that CCAAT/enhancer-binding protein β (C/EBP β) associated with regulation autophagy. Herein, we hypothesized C/EBP plays roles inducing cells. Expression was aberrantly regulated endothelial and retinal pigment epithelial...