A5040276349- Fibroblast Growth Factor Research
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Proteoglycans and glycosaminoglycans research
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Glutathione Transferases and Polymorphisms
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Animal Genetics and Reproduction
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Thyroid Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Glioma Diagnosis and Treatment
- Biological Research and Disease Studies
- Enzyme Production and Characterization
- Computational Drug Discovery Methods
- Ferroptosis and cancer prognosis
Eurofins (United States)
2022-2024
University of Colorado Anschutz Medical Campus
2017-2023
The University of Kansas Cancer Center
2018-2021
University of Kansas Medical Center
2019-2021
Wellcome Centre for Mitochondrial Research
2019
University Medical Center
2018-2019
University of Colorado Denver
2016-2018
University of Minnesota
2010-2014
Masonic Cancer Center
2013
Hamline University
2013
Tumor formation is an extensive process requiring complex interactions that involve both tumor cell-intrinsic pathways and soluble mediators within the microenvironment. cells exploit intrinsic functions of many molecules, including chemokines their receptors, to regulate pro-tumorigenic phenotypes are required for growth progression primary tumor. Previous studies have shown activation inducible FGFR1 (iFGFR1) in mammary epithelial resulted increased proliferation, migration, invasion vitro...
Aberrant activation of fibroblast growth factor receptors (FGFR) contributes to breast cancer growth, progression, and therapeutic resistance. Because the complex nature FGF/FGFR axis, numerous effects FGFR on tumor cells surrounding microenvironment, specific mechanisms through which aberrant activity are not completely understood. We show here that induces accumulation hyaluronan within extracellular matrix blocking synthesis decreases proliferation, migration, Furthermore, FGFR-mediated...
Advanced stages of papillary and anaplastic thyroid cancer continue to be plagued by a dismal prognosis, which is result limited effective therapies for these cancers. Due the high proportion cancers harboring mutations in MAPK pathway, pathway has become focal point therapeutic intervention cancer. Unfortunately, unlike melanoma, similar responsiveness inhibition yet observed patients. To address this issue, we have focused on targeting non-receptor tyrosine kinase, Src, others demonstrated...
Advanced stages of papillary and anaplastic thyroid cancer represent a highly aggressive subset, in which there are currently few effective therapies. We others have recently demonstrated that c-SRC is key mediator growth, invasion, metastasis, therefore represents promising therapeutic target cancer. However, clinically, Src inhibitor efficacy has been limited, further insights needed to define resistance mechanisms determine rational combination generated four cell lines with greater than...
Mitochondria contribute to tumor growth through multiple metabolic pathways, regulation of extracellular pH, calcium signaling, and apoptosis. Using the Mitochondrial Nuclear Exchange (MNX) mouse models, which pair nuclear genomes with different mitochondrial genomes, we previously showed that SNPs regulate mammary carcinoma tumorigenicity metastatic potential in genetic crosses. Here, tested hypothesis polymorphisms stroma significantly affect experimental lung metastasis. syngeneic cancer...
Gene therapy, cell therapy and vaccine research have led to an increased need perform cellular immunity testing in a regulated environment ensure the safety efficacy of these treatments. The most common method for measurement has been Enzyme-Linked Immunospot assays. However, there is lack regulatory guidance available discussing recommendations developing validating types Hence, Global CRO Council issued this white paper provide consensus on different validation parameters required support...
Thyroid cancer is the most common endocrine neoplasm, and despite its overall high survival rate, patients with metastatic disease or tumors that resist radioactive iodine experience a significantly worse prognosis. Helping these requires better understanding of how therapeutics alter cellular function. Here, we describe change in metabolite profiles after treating thyroid cells kinase inhibitors dasatinib trametinib. We reveal alterations to glycolysis, TCA cycle, amino acid levels. also...
Translation initiation factor eIF4E mediates normal cell proliferation, yet induces tumorigenesis when overexpressed. The mechanisms by which directs such distinct biologic outputs remain unknown. We found that mouse mammary morphogenesis during pregnancy and lactation is accompanied increased cap-binding capability of activation the eIF4E-dependent translational apparatus, but only subtle oscillations in abundance. Using a transgenic model engineered so lactogenic hormones stimulate...
Abstract Background Previously, we identified ITIH5 as a suppressor of pancreatic ductal adenocarcinoma (PDAC) metastasis in experimental models. Expression correlated with decreased cell motility, invasion and without significant inhibition primary tumour growth. Here, tested whether secretion is required to suppress liver sought understand the role human PDAC. Methods We expressed mutant deletion N-terminal sequence (ITIH5Δs) highly metastatic PDAC lines. used tissue microarray (TMA)...
// Katie M. Mishall 1 , Thomas C. Beadnell Brent Kuenzi 2, 3 Dorothy Klimczak Giulio Superti-Furga 4, 5 Uwe Rix 2 and Rebecca E. Schweppe Department of Medicine, Division Endocrinology, Metabolism Diabetes, School University Colorado Anschutz Medical Campus, Aurora, Colorado, USA Drug Discovery, Moffitt Cancer Center & Research Institute, Tampa, Florida, Biology PhD Program, South 4 CeMM for Molecular Austrian Academy Sciences, Vienna, Austria Physiology Pharmacology, Correspondence to:...
INTRODUCTION: Glioblastoma multiforme (GBM) is the most malignant and common primary brain tumor. There no curative chemotherapeutic regimen for GBM, its invasiveness greatly limits efficacy of surgery radiation therapy. Molecular drivers GBM growth, maintenance, invasion need to be identified develop effective therapies. METHODS: We selected 50 genes found overexpressed in a high proportion comprehensive sequencing gene expression analysis studies by The Cancer Genome Atlas (TCGA) Research...
<div>Abstract<p>Translation initiation factor eIF4E mediates normal cell proliferation, yet induces tumorigenesis when overexpressed. The mechanisms by which directs such distinct biologic outputs remain unknown. We found that mouse mammary morphogenesis during pregnancy and lactation is accompanied increased cap-binding capability of activation the eIF4E-dependent translational apparatus, but only subtle oscillations in abundance. Using a transgenic model engineered so...
<div>Abstract<p>Aberrant activation of fibroblast growth factor receptors (FGFR) contributes to breast cancer growth, progression, and therapeutic resistance. Because the complex nature FGF/FGFR axis, numerous effects FGFR on tumor cells surrounding microenvironment, specific mechanisms through which aberrant activity are not completely understood. We show here that induces accumulation hyaluronan within extracellular matrix blocking synthesis decreases proliferation, migration,...
<div>Abstract<p>Mitochondria contribute to tumor growth through multiple metabolic pathways, regulation of extracellular pH, calcium signaling, and apoptosis. Using the Mitochondrial Nuclear Exchange (MNX) mouse models, which pair nuclear genomes with different mitochondrial genomes, we previously showed that SNPs regulate mammary carcinoma tumorigenicity metastatic potential in genetic crosses. Here, tested hypothesis polymorphisms stroma significantly affect experimental lung...
<p>Supplementary Fig. S3. Double K8/Ki-67staining of wild type (WT) and transgenic (WAP-4E) mammary glands (gestation 6).</p>
<p>Supplementary Fig. S5. HA-eIF4E rescues HMEC/hTERT cells from Ras-induced senescence and activates ATR signaling.</p>