A5040169618- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Parasites and Host Interactions
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Parasitic Diseases Research and Treatment
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Gut microbiota and health
- Monoclonal and Polyclonal Antibodies Research
- Clostridium difficile and Clostridium perfringens research
- Bacterial Infections and Vaccines
- Immunotherapy and Immune Responses
- Eosinophilic Esophagitis
- Child Nutrition and Water Access
- Parasite Biology and Host Interactions
Johns Hopkins Medicine
2024-2025
Johns Hopkins University
2024-2025
James Cook University
2016-2019
Australian Institute of Tropical Health and Medicine
2016-2019
Inflammasomes promote immunity to microbial pathogens by regulating the function of IL-1-family cytokines such as IL-18 and IL-1β. However, roles for inflammasomes during parasitic helminth infections remain unclear. We demonstrate that mice humans infected with gastrointestinal nematodes display increased secretion, which in Trichuris-infected or worm antigen-treated macrophages co-cultured Trichuris antigens exosome-like vesicles was dependent on NLRP3 inflammasome. NLRP3-deficient...
Abstract Alternatively activated macrophages are essential effector cells during type 2 immunity and tissue repair following helminth infections. We previously showed that Ym1, an alternative activation marker, can drive innate IL-1R–dependent neutrophil recruitment infection with the lung-migrating nematode, Nippostrongylus brasiliensis, suggesting a potential role for inflammasome in IL-1–mediated response to infection. Although proteins such as NLRP3 have important proinflammatory...
Abstract Alternatively activated macrophages are essential effector cells during type 2 immunity and tissue repair following helminth infections. We previously showed that Ym1, an alternative activation marker, can drive innate IL-1R-dependent neutrophil recruitment infection with the lung-migrating nematode, Nippostrongylus brasiliensis suggesting a potential role for inflammasome in IL-1-mediated response to infection. While proteins such as NLRP3 have important pro-inflammatory functions...
Dual-expressing lymphocytes (DEs) are unique immune cells that express both B cell receptors (BCRs, surface antibody) and T (TCRs). In type 1 diabetes, DE antibodies predominated by one antibody (x-mAb), an IgM monoclonal with a germline-encoded CDR3 recognizes self-reactive TCRs. We explored if x-mAb its interacting TCRs have distinct structural features.