A5028684975- Immunotoxicology and immune responses
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Reproductive System and Pregnancy
- Animal testing and alternatives
- Heavy Metal Exposure and Toxicity
- Environmental Toxicology and Ecotoxicology
- Birth, Development, and Health
- Bird parasitology and diseases
- Turtle Biology and Conservation
- Animal Nutrition and Physiology
- Pesticide Exposure and Toxicity
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Anatomy and Medical Technology
- Immunotherapy and Immune Responses
- Mercury impact and mitigation studies
- Amphibian and Reptile Biology
- Neonatal Respiratory Health Research
- Spatial Cognition and Navigation
- Toxoplasma gondii Research Studies
- Prenatal Screening and Diagnostics
University of Georgia
2015-2025
Virginia Tech
2001-2015
Virginia–Maryland College of Veterinary Medicine
2001-2010
Center for Molecular Medicine and Immunology
2008
Cornell University
2000
Purdue University West Lafayette
1999
North Carolina State University
1983-1993
National Institute of Environmental Health Sciences
1991-1993
Triangle
1993
Research Triangle Park Foundation
1993
In utero exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was found alter expression of murine thymocyte fetal cell-surface markers. Pregnant mice were treated (via gavage) with 0, 1.5, or 3.0 micrograms TCDD/kg/day in corn oil on gestational days (gd) 6-14. Offspring examined gd 18 and postnatally d6, d14, d21, at 7, 8, 10 weeks age. Severe thymic atrophy cellular depletion both pre- TCDD-exposed mice. Immunocytochemical localization Thy 1.2 antigen...
Infection by Salmonella Typhimurium, a food-borne pathogen, can reduce the poultry production efficiency. The objective of this study was to investigate effects tannic acid (TA) supplementation on growth performance, colonization, gut barrier integrity, serum endotoxin levels, antioxidant capacity, health, and immune function in broilers infected with enterica serovar Typhimurium nalidixic resistant strain (ST
Introduction We suggest an objective ranking formula that has wide national and international application. The new is presented with U.S. Colleges of Veterinary Medicine as example. Methods used by agencies differ, do the ranks they generate. In some instances, relatively narrow information collected from a limited number polled contributors, raising questions about strength validity generated ranks. A formula-based weighted model for veterinary colleges proposed. Numbers fed into...
Whole blood and keratin mercury concentrations, complete cell counts, plasma biochemical health profiles were evaluated in 31 juvenile cold-stunned Kemp's ridley turtles (Lepidochelys kempii) from Cape Cod, Massachusetts. In addition, copper, zinc, selenium, cadmium concentrations measured for 16 of these turtles. Liver 6 that dead upon acquisition or died during rehabilitation. Concentrations 18 organochlorine pesticides live turtles, liver, kidney, fat, brain 3 deceased Metal levels...
Background Maternal immune stimulation reduces malformations caused by chemical teratogens. Mechanisms for this effect are not known. Altered expression of regulatory molecules (e.g., transforming growth factor [TGF-β], tumor necrosis factor-α [TNF-α]) has been reported in fetuses from immunostimulated mice, which may affect gene expression. Expression selected genes that function to control proliferation, differentiation, or apoptosis was evaluated chemical-exposed fetuses, with without...
Background Chemical induction of apoptosis in cells is believed to contribute toxicity. Techniques for measuring have increased both sensitivity and number many cases can be readily extended nontraditional research species. A comparison established assays lymphoid has thus far not been performed the fish would efficacious assessing immunotoxicity. Methods The present study evaluated chemical-induced immune cell (tilapia, Oreochromis niloticus) exposed two known immunotoxic chemicals,...
The outcome of immunological assays is markedly influenced by the method isolation lymphocytes. It is, therefore, important to comparatively assess various techniques lymphocytes, an aspect thus far not thoroughly addressed. In particular, potential influence cell recovery, viability, and function has yet been evaluated. These studies were designed determine effect different mechanical tissue dissociation methods on viability Following spleen thymus removal, lymphoid organs dissociated one...
Abstract Tiger salamanders ( Ambystoma tigrinum ) were exposed via soil and/or food (earthworms) to 2,4,6‐trinitrotoluene (TNT) and a PCB mixture (Aroclor 1260) at environmentally relevant concentrations. Four exposures considered: (1) uncontaminated + (control group); (2) contaminated (dermal (3) (oral and, (4) (dual‐exposure group). The chemical exposure was estimated for each group by analysis of both earthworms. Body burdens TNT its primary metabolites highest in the dermal groups while...