A5090302850- Alzheimer's disease research and treatments
- Metabolism, Diabetes, and Cancer
- Estrogen and related hormone effects
- Growth Hormone and Insulin-like Growth Factors
- S100 Proteins and Annexins
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Hormonal and reproductive studies
- Neurological Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Folate and B Vitamins Research
- Cancer, Lipids, and Metabolism
- Cancer-related cognitive impairment studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Histone Deacetylase Inhibitors Research
- Marine and coastal plant biology
- Natural Antidiabetic Agents Studies
- Coral and Marine Ecosystems Studies
- FOXO transcription factor regulation
- Phytochemicals and Medicinal Plants
- Plant Pathogens and Resistance
- Plant Pathogens and Fungal Diseases
- Climate Change and Sustainable Development
- Genetic Syndromes and Imprinting
Southmead Hospital
2020-2025
University of Bristol
2010-2023
Cardiff University
2012
North Bristol NHS Trust
2010-2011
Dementia UK
2010
Frenchay Hospital
2010
University of Birmingham
2000
Little is known about the contributors and physiological responses to white matter hypoperfusion in human brain. We previously showed ratio of myelin-associated glycoprotein proteolipid protein 1 post-mortem brain tissue correlates with degree ante-mortem ischaemia. In age-matched cohorts Alzheimer's disease (n = 49), vascular dementia 17) control brains 33) from South West Dementia Brain Bank (Bristol), we have now examined relationship between several other proteins involved regulating...
Vascular dysfunction and lowered cerebral blood flow are thought to contribute the development progression of Alzheimer's disease (AD). Endothelin-1 (ET-1) is a potent vasoconstrictor, production which mainly catalyzed by endothelin-converting enzymes (ECEs). We previously showed t hat ECE-2 upregulated amyloid-β (Aβ), its expression elevated in AD postmortem brain tissue. have now investigated whether there concomitant increase ET-1. studied temporal cortex from 20 cases sporadic matched...
White matter ischemia is difficult to quantify histologically. Myelin-associated glycoprotein (MAG) highly susceptible ischemia, being expressed only adaxonally, far from the oligodendrocyte cell body. Myelin-basic protein (MBP) and proteolipid (PLP) are throughout myelin sheath. We compared MAG, MBP, PLP levels in parietal white homogenates 17 vascular dementia (VaD), 49 Alzheimer's disease (AD), 33 control brains, after assessing post-mortem stability of these proteins. Small vessel (SVD)...
An apparent "inverse" relationship exists between two seemingly unconnected conditions: Alzheimer's disease (AD) and cancer, despite sharing similar risk factors, like increased age obesity. AD is associated with amyloid beta (Aβ) plaques neurofibrillary tau tangles that cause neural degeneration; in contrast, characterised by enhanced cell survival proliferation. Apolipoprotein E (ApoE) the main lipoprotein found central nervous system via its high affinity receptors plays a...
Accumulation and deposition of Aβ is one the main neuropathological hallmarks Alzheimer's disease (AD) impaired degradation may be mechanism accumulation. Plasmin key protease plasminogen system can cleave Aβ. activated from by tissue activator (tPA) urokinase-type (uPA). The activators are regulated inhibitors which include inhibitor-1 (PAI-1) neuroserpin. also including α2-antiplasmin α2-macroglobulin. Here, we investigate mRNA levels protein tPA, neuroserpin in post-mortem AD control...
// Rehanna Mansor 1 , 2 Jeff Holly Rachel Barker Kalina Biernacka Hanna Zielinska Anthony Koupparis 3 Edward Rowe Jon Oxley 4 Alex Sewell Richard M. Martin 5 6 Athene Lane Lucy Hackshaw-McGeagh and Claire Perks IGFs Metabolic Endocrinology Group, Bristol Medical School, Translational Health Sciences, University of Bristol, Southmead Hospital, UK Faculty Medicine, Royal College Medicine Perak, Universiti Kuala Lumpur, Ipoh, MY Department Urology, Urological Institute, Cellular Pathology,...
The role if insulin-like growth factor binding protein-2 (IGFBP-2) in mediating chemoresistance breast cancer cells has been demonstrated, but the mechanism of action is unclear. This study aimed to further investigate IGFBP-2 DNA damage response induced by etoposide MCF-7, T47D (ER+ve), and MDA-MB-231 (ER-ve) cell lines. In presence or absence etoposide, was silenced using siRNA ER-positive lines, exogenous added ER-negative cells. Cell number death were assessed trypan blue dye exclusion...
Prostate cancer is the second major cause of male deaths. Obesity, type 2 diabetes, and risk are linked. Insulin-like growth factor II (IGF-II) involved in numerous cellular events, including proliferation survival. The IGF-II gene shares its locus with lncRNA, H19. IGF-II/H19 was first to be identified as being “imprinted”—where paternal copy not transcribed—a silencing phenomenon lost many types. We disrupted imprinting behaviour vitro by altering metabolic conditions quantified it using...
Prostate cancer (PCa) is one of the leading causes cancer-related deaths in men. Localised PCa can be treated effectively, but most patients relapse/progress to more aggressive disease. One possible mechanism underlying this progression alternative splicing androgen receptor, with AR variant 7(ARV7) considered play a major role. Using viability assays, we confirmed that ARV7-positive cells were less sensitive treatment cabazitaxel and an anti-androgen-enzalutamide. Also, using...
Insulin receptor substrate-2 (IRS-2), a substrate of the insulin-like growth factor (IGF)-I receptor, is highly expressed in prostate cancer cell line, PC3. We recently demonstrated that extracellular signal-regulated kinase (Erk1/2), downstream IGF signaling, activated PC3 cells under serum starvation, and this activation can be inhibited by IRS-2 knockdown. Here, we observed adding an IGF-I-neutralizing antibody to culture medium Erk1/2. Suppression Erk1/2 knockdown was restored addition...