A5039537941- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Pneumonia and Respiratory Infections
- Tracheal and airway disorders
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Heart Disease Studies
- Congenital Anomalies and Fetal Surgery
- Transplantation: Methods and Outcomes
- Dysphagia Assessment and Management
- Vasculitis and related conditions
- Gut microbiota and health
- Emergency and Acute Care Studies
- Ultrasound in Clinical Applications
- Lymphatic Disorders and Treatments
- Esophageal and GI Pathology
- COVID-19 and healthcare impacts
- Gastroesophageal reflux and treatments
- Child Nutrition and Feeding Issues
- Infant Development and Preterm Care
- Aortic Disease and Treatment Approaches
- Pediatric Urology and Nephrology Studies
- Pharmacological Effects and Assays
Rambam Health Care Campus
2018-2025
Technion – Israel Institute of Technology
2022-2025
Emek Medical Center
2014-2021
While the positive effect of Trikafta on cystic fibrosis (CF) pulmonary disease is well established, there limited data about its bone mineral density (BMD), body composition and exercise capacity.A pilot single center study. BMD were measured three months after initiation (study group) compared to values obtained 2 years earlier. CF patients not treated with Trikafta, for whom was apart, served as controls. Spirometry, lung clearance index (LCI), sweat test, six-min walk test (6MWT)...
To compare the Respiratory Syncytial Virus (RSV) hospitalization burden among 29-34 weeks gestational age (wGA) preterm infants between seasons with and without routine palivizumab prophylaxis, by utilizing 2021 off-season RSV surge. This multi-center retrospective study was conducted in 11 medical centers across Israel. We included > 1 year-old, wGA data, hospitalized infection from November 2017-August 2021. National compliance data were collected separately. compared two periods:...
ABSTRACT Objective Children less than two years of age with a prolonged or severe course bronchiolitis are usually referred for Echocardiographic evaluation during hospitalization. Our aim was to assess the yield Echocardiography (Echo) in these children and possible characteristics predicting positive Echo findings. Study Design This retrospective study over 10 included all under admitted acute bronchiolitis. Data collected using MDClone query tool. abnormal findings (positive Echo) were...
Community acquired pneumonia (CAP) is a leading cause of morbidity in children, despite advances health care and anti-pneumococcal vaccine. Complicated accounts for significant burden with prolonged hospitalization. Finding risk factors complicated may help tailoring management. We aimed to identify developing need intervention.A retrospective single tertiary center study. Children admitted diagnosis CAP and/or (parapneumonic effusion, empyema, necrotizing pneumonia, lung abscess) on January...
Abstract Background and Objectives Multiple factors affect bone mineral density (BMD) in cystic fibrosis (CF). Our aim was to perform comprehensive analyses of parameters potentially contributing BMD. Methods A prospective single‐center study assessing BMD, correlations with multiple including pancreatic status, lung functions, 6‐minute walk test (6MWT), clinical score (modified Shwachman‐Kulczycki [SK] score), vitamin D, nutritional intake, hand grip strength (HGS), habitual physical...
Objectives: To evaluate and describe the spectrum rate of congenital thoracic malformations (CTMs) diagnosed by early prenatal sonography (gestational age (GA) less than 16 weeks). Methods: A retrospective, cross-sectional analysis ultrasound screening tests in a community-based clinic. Results: In 2001-2017, 31 261 detected CTMs at gestational 15.2 (range, 11.6-16.0) weeks. The most common malformation was pleural effusion (CPE) (15 fetuses, 0.48/1000), followed diaphragmatic hernia (CDH)...
The increased and earlier use of prenatal ultrasound has facilitated the detection congenital thoracic malformations (CTMs). Our Pediatric Pulmonology Institute follows an increasing number patients with CTMs. Thus, we aimed to evaluate describe sonographic findings CTM, estimate changes in rates CTMs over a period 16 years.A retrospective, cross-section analysis (US) screening tests carried out large community-based clinic, comparing two periods: 2001-2007 2007-2017.A total 34 716 US were...
The 6-min walk test (6MWT) predicts outcome in pulmonary hypertension. Recently, its use was reported both cystic fibrosis (CF) and bronchiolitis obliterans (BO). While the 6MWT is a simple, non-invasive inexpensive tool, lung clearance index (LCI) measurement requires expensive equipment expertise. We aimed to evaluate BO CF, compare MBW (multiple breath washout), function tests quality of life (QOL).A prospective single center study assessing 6MWT, MBW, spirometry, whole-body...
Cystic fibrosis (CF)-related diabetes (CFRD) affects 50% of CF adults. Gut microbial imbalance (dysbiosis) aggravates their inflammatory response and contributes to insulin resistance (IR). We hypothesized that probiotics may improve glucose tolerance by correcting dysbiosis.A single-center prospective pilot study assessing the effect Vivomixx® probiotic (450 billion/sachet) on clinical status, spirometry, lung clearance index (LCI), quality life (QOL) questionnaires; parameters (urine stool...
Following the opening of lockdown and relaxation public health restrictions, an unusual surge respiratory illness occurred during spring/summer (Q2) 2021 season. We aimed to characterize this compared previous years.Children discharged from a single tertiary hospital for or selected noncommunicable diseases (NCDs) between 2015 were included, hospitalization rates compared. To evaluate whether current resembles typical winter, characteristics second quarter (Q2, April-June) parallel seasons...
Assessing disease severity in patients with cystic fibrosis (CF) is essential when directing therapies. Serum immunoglobulin G (IgG) levels increase severity. Lung clearance index (LCI) recognized as an outcome measure for CF clinical trials. Our aim was to evaluate the correlations between IgG and markers. This a single-center retrospective study, evaluating association markers of (including characteristics, lung spirometry, LCI, scores computed tomography (CT) scores) during stable...
We aimed to evaluate the impact of respiratory symptoms and positive viral testing on risk serious bacterial infections (SBIs). A retrospective study was conducted that included infants (0-60 days) presenting with a fever between 2001 2022 at tertiary hospital in northern Israel. Demographic, clinical, laboratory parameters were collected, factors for SBIs analyzed. Data from total 3106 infants, including data blood, urine, CSF cultures, obtained 96.6%, 89%, 29% cases, respectively. without...
Abstract Background Vascular rings are congenital anomalies of the aortic arch that compress trachea and esophagus may require corrective surgery. Data about long‐term effects vascular scarce. We aimed to evaluate cardiorespiratory, exercise capacity, quality life ring patients. Methods A single center prospective study evaluating spirometry, echocardiography, six‐minute walk test (6MWT), cardiopulmonary testing (CPET), questionnaire (SF36) in patients with a diagnosis ring, or without...
Abstract Purpose Relvar® (fluticasone furoate [FF]/vilanterol [VI]) is a once‐daily inhaler with bronchodilator effect lasting 24 h. Our aim was to investigate the short‐ and long‐term effects of FF/VI on exercise‐induced asthma (EIA) in adolescents. Methods Ninety‐three adolescent asthmatics aged 12–18 years were referred for evaluation EIA. Following positive exercise challenge test (ECT), 22/44 allocated single administration salbutamol (400 μg) (92/22 double‐blind method. Thirty‐five...
<b>Objective:</b> We utilized the opportunity of highload off-season RSV admissions with no prophylaxis given during summer 2021, to assess impact withholding palivizumab on relative burden among hospitalized 29-34 wGA infants. <b>Methods:</b> This was a national multi-center retrospective study conducted in 11 medical centers. included infants under 12 months who were between November 2017-August 2021. extracted demographics and clinical data from records categorized our cohort into an...
Abstract Background Respiratory syncytial virus (RSV) prophylaxis provided during the winter to infants born at 29–34-week gestational age (wGA) is controversial. We utilized unprecedented opportunity of high load off-season RSV admissions with no given summer 2021, assess impact withholding palivizumab on relative burden hospitalized 29-34 wGA infants. Methods This was a national multi-center observational retrospective study in 11 medical centers Israel. included under 1 year-old, who were...
The authors declare no conflict of interest.
Background: Vascular rings are congenital anomalies of the aortic arch that compress trachea and esophagus may require corrective surgery. Data about long-term effects vascular scarce. We aimed to evaluate cardiorespiratory, exercise capacity quality life ring patients. Methods: A single center prospective study evaluating spirometry, echocardiography, six-minute walk test (6MWT), cardiopulmonary testing (CPET) questionnaire (SF36) in patients with a diagnosis ring, or without Results:...