Constance Lamy
A5089333180- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Neuroblastoma Research and Treatments
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Chromosomal and Genetic Variations
- Immune cells in cancer
- Mitochondrial Function and Pathology
- vaccines and immunoinformatics approaches
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Autophagy in Disease and Therapy
- Phagocytosis and Immune Regulation
- Neuroendocrine Tumor Research Advances
- Ubiquitin and proteasome pathways
- Metabolomics and Mass Spectrometry Studies
Université Paris-Saclay
2021-2024
Institut Gustave Roussy
2019-2024
Inserm
2020-2024
Institut Curie
2024
Radiothérapie Moléculaire et Innovation Thérapeutique
2021
<p>Fig S9. Age has a minor effect on L1PA DNA methylation patterns and is not confounding factor in this study</p>
<p>Fig S5. Comparison of tumor and plasma paired samples</p>
<p>Fig S8. DIAMOND profiles and performances in the validation versus discovery cohorts</p>
<p>Fig S11. 2 step-models integrating CNA signal extracted from DIAMOND data</p>
<p>Fig S6. Classifier performances: feature types, calculation parameters, cancer subtypes and stages</p>
<p>Fig S8. DIAMOND profiles and performances in the validation versus discovery cohorts</p>
<p>Fig S10. Comparison of multiple classifiers (expert, all, stack and blind models) prognostic value L1PA hypomethylation</p>
<p>Fig S5. Comparison of tumor and plasma paired samples</p>
<p>Fig S3. Preparation of L1PA targeted bisulfite sequencing libraries and analysis workflow</p>
<p>Fig S1. cfDNA extraction methods did not impact the L1PA methylation patterns</p>
<p>Fig S9. Age has a minor effect on L1PA DNA methylation patterns and is not confounding factor in this study</p>
<p>Fig S4. DIAMOND features: CpG calling and contribution of CG positions or haplotypes</p>
<p>Fig S2. Methylation profiles obtained with bisulfite or enzymatic conversion are similar</p>
<div>AbstractPurpose:<p>The detection of ctDNA, which allows noninvasive tumor molecular profiling and disease follow-up, promises optimal individualized management patients with cancer. However, detecting small fractions DNA released when the burden is reduced remains a challenge.</p>Experimental Design:<p>We implemented new, highly sensitive strategy to detect bp resolution methylation patterns from plasma assessed potential hypomethylation long interspersed nuclear...
<p>Fig S6. Classifier performances: feature types, calculation parameters, cancer subtypes and stages</p>
<p>Fig S11. 2 step-models integrating CNA signal extracted from DIAMOND data</p>
<p>Fig S4. DIAMOND features: CpG calling and contribution of CG positions or haplotypes</p>
<p>Fig S2. Methylation profiles obtained with bisulfite or enzymatic conversion are similar</p>
<p>Fig S3. Preparation of L1PA targeted bisulfite sequencing libraries and analysis workflow</p>
<p>Fig S7. Extraction of L1PA DNA hypomethylation signal from whole genome data</p>
<p>Fig S7. Extraction of L1PA DNA hypomethylation signal from whole genome data</p>
Abstract Context Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors that frequently associated with succinate dehydrogenase (SDH) germline mutations. When mutated, SDH losses its function, thus leading to accumulation. Objective In this study, we evaluated serum levels as a new metabolic biomarker in SDHx-related carriers. Methods Retrospective monocentric study of 88 PPGL patients (43 sporadic, 35 SDHB, 10 SDHA/C/D), 17 tumor-free familial asymptomatic carriers (13 4...
Abstract Background Tumor-associated macrophages (TAMs) are essential components of the inflammatory microenvironment tumors and associated with poor clinical outcomes in majority cancers. TAMs mainly exhibit anti-inflammatory functions that promote support tissue remodeling, immune suppression tumor growth. Regarding their plasticity, functional reprogramming into proinflammatory phenotype recently emerged as a therapeutic opportunity to improve effectiveness anticancer treatments such...