Protein kinase R (PKR) is a vital component of host innate immunity against viral infection. However, the mechanism underlying inactivation PKR by influenza A virus (IAV) remains elusive. Here, we found that vault RNAs (vtRNAs) were greatly induced in A549 cells and mouse lungs after infection with IAV. The NS1 protein was shown to be inducer triggering upregulation vtRNAs. Importantly, silencing vtRNA significantly inhibited IAV replication, whereas overexpression vtRNAs markedly promoted...

The lower energy density and safety issues of liquid sodium-ion batteries have been unable to satisfy the ever-increasing demands for large-scale storage system. As a low-cost alternative, solid-state sodium metal (SSMBs) shown great competitive advantages extensive application prospects due their high desirable safety. However, electrolytes (SSEs) often possess low ionic conductivity, poor interface compatibility inferior stability between SSEs electrodes can result in continuous...

Radiotherapy (RT) effectiveness is limited by low DNA damage in tumor cells, surrounding tissue harm, and radioresistance with active repair. Herein, we have engineered a two-dimensional nanomaterial consisting of MXene nanosheets at its core, coated gold nanorods cisplatin shell, further modified polyvinyl alcohol, referred to as APMP. The APMP exploits distinctive electronic properties photothermal effects augment radiosensitivity impede repair mechanisms. In vitro experiments demonstrate...

Abstract Item nonresponses frequently occurs in educational and psychological assessments, if not appropriately handled, it can undermine the reliability of results. This study introduces a missing data model based on at random (MNAR) mechanism, incorporating monotonic missingness assumption to capture individual‐level patterns behavioral dynamics. In specific, cumulative number indicators allows consider tendency current item's previous missingnesses, which reduces nuisance parameters for...

WRKY transcription factors are involved in stress responses plants; however, their roles abiotic stresses still not well known Malus plants. In the present study, a gene was isolated from baccata (L.) Borkh and designated as MbWRKY1. Subcellular localization revealed that MbWRKY1 localized nucleus. The expression levels of were up-regulated by dehydration, salinity, ABA treatments M. seedlings. When introduced into tobacco, it improved drought tolerance transgenic Under treatment, plants had...

Plant-specific WRKY transcription factors are widely involved in abiotic stress responses. In this study, a gene was isolated from Malus baccata (L.) Borkh and designated it as MbWRKY2. Subcellular localization showed that MbWRKY2 localized the nucleus. The expression levels of were up-regulated by stresses M. baccata. When introduced into tobacco, improved drought tolerance transgenic plants. tobaccos had higher contents chlorophyl, proline, relative water content, AsA, GSH, increased...

Plant-specific WRKY transcription factors were involved in stress responses and ABA signaling. In the present study, a gene is isolated from Malus baccata (L.) Borkh designated as MbWRKY3. Subcellular localization revealed that MbWRKY3 was localized onto nucleus. The expression levels up-regulated by salinity, drought, treatments M. baccata. When introduced into tobaccos, it improved drought tolerance transgenic plants. Compared to WT, tobaccos had higher of relative water content, proline...

Deubiquitylating enzyme ubiquitin-specific protease 1 (USP1) has been reported to be aberrantly overexpressed in cancers, and it plays a critical role regulating various cellular processes, such as cell proliferation, apoptosis, differentiation.However, the of USP1 B-cell acute lymphoblastic leukemia (B-ALL) remains largely undefined.USP1 expression 30 newly diagnosed B-ALL patients was detected by real-time PCR western blot.We found that generally upregulated bone marrow cells derived from...

This study deals with numerical and experimental free vibration analysis of through-the-thickness cylindrical polymer pin-reinforced foam core sandwich composite panels two different thicknesses. Four pin-reinforcement configurations varying pin diameters center distances were used. First five non-zero eigenfrequencies retrieved along their eigenmodes in the analysis. Experimental modal was done for validation The results revealed that pin-configuration densest allocation biggest diameter...

Efficient sorting multiple orbital angular momentum (OAM) spatial modes is a significant step in OAM multiplexing communications. Recently, wavefront shaping (WS) techniques have been implemented to manipulate light scattering through diffuser. We reported novel scheme for multiplexed faster and more accurately, using the complex amplitude WS based on digital micromirror device (DMD) diffuser shape full field (phase amplitude) of modes. In this study, we simulate sorter demultiplexing make...

To solve the problem of high harmonic in stator current Permanent-Magnet Synchronous Motor (PMSM), a suppression method combining Three-parameter Notch Filter (TNF) and Linear Active Disturbance Rejection Controller (LADRC) is proposed. First, loop controller adopts LADRC, extended state observer (LESO) used to estimate disturbance signal. The performance studied frequency domain. Second, TNF extract feedforward compensation signals specific frequency, which further weakens influence medium...

Video super-resolution aims to generate high-resolution frames from low-resolution counterparts. It can be regarded as a specialized application of image super-resolution, serving various purposes, such video display and surveillance. This paper proposes novel method for real-time super-resolution. effectively exploits spatial information by utilizing the capabilities an model leverages temporal inherent in videos. Specifically, incorporates pre-trained network its foundational framework,...

We suggest a continuous variable quantum conferencing network scheme with an entangled source in the middle. Here, generates multipartite state and distributes modes of to arbitrary number legitimate users. The that were received measured by users share mutual information, which is utilized generate secure key between proven against collective attacks on both untrusted middle all links. Simulation results show presented can achieve high rate for 100 within 400 m-radius community or factory area.

Interior Permanent Magnet Synchronous Motor (IPMSM) significantly speed fluctuations under load change suddenly conditions. With the help of MATLAB/Simulink simulation software, a novel IPMSM loop control strategy is studied. A Fuzzy linear active disturbance rejection (Fuzzy-LADRC) controller designed, and LADRC parameters are dynamically adjusted by to reduce in this paper. Finally, dSPACE experimental platform used conduct simulations experiments. The results show that Fuzzy-LADRC has...

Titanium alloys are crucial in precision manufacturing due to their exceptional properties, but traditional machining methods lead tool wear, deformation, and high costs. Conventional cooling fluids reduce heat cause environmental issues, necessitating more sustainable solutions. Cryogenic Minimum Quantity Lubrication (CMQL) technology, using liquid nitrogen or carbon dioxide with minimal amounts of cutting fluid, offers an eco-friendly alternative that reduces temperatures friction. This...

With the increasing demanding for precision of test feedback, cognitive diagnosis models have attracted more and attention to fine classify students whether has mastered some skills. The purpose this paper is propose a highly effective Pólya-Gamma Gibbs sampling algorithm based on auxiliary variables estimate deterministic inputs, noisy “and” gate model (DINA) that been widely used in study. new not only avoids Metroplis-Hastings boring adjustment turning parameters achieve an appropriate...

A general structure of motor-brake pedal is put forward to solve the problem automatic parking system for intelligent driving on traditional fuel vehicles. At same time, as large fluctuation conventional PID control and parameters cannot be changed in realtime, fuzzy-PID method used rotation angle pedal. Firstly, designed replace original mechanism. Then fuzzy controller vehicle model are established. By comparing simulation results control, it proved that has better effect. Finally, whole...

Short-term load forecasting is the basis of power system regulation, and it affects many decisions system. In order to deal with challenge decline in prediction accuracy caused by reduction cost, improve speed, an improved extreme learning machine algorithm, which combines prior knowledge residential electricity consumption habits proposed automatically select number hidden layer neurons effect. The purpose achieve a better short-term effect less manpower material resources mining...