A5023249940- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Click Chemistry and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Antimicrobial Peptides and Activities
- Carbohydrate Chemistry and Synthesis
- Synthesis and Catalytic Reactions
- DNA and Nucleic Acid Chemistry
- Synthetic Organic Chemistry Methods
- Cyclopropane Reaction Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Fluorine in Organic Chemistry
- Cellular Mechanics and Interactions
- Metal complexes synthesis and properties
- Mathematical Biology Tumor Growth
- Hemoglobin structure and function
- Aldose Reductase and Taurine
- Synthesis and Characterization of Pyrroles
- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Enzyme function and inhibition
- Axial and Atropisomeric Chirality Synthesis
- Phenothiazines and Benzothiazines Synthesis and Activities
Yerevan State University
2013-2025
Scientific Center of Zoology and Hydroecology
2014-2025
National Academy of Sciences of Armenia
2013-2025
Western University
2011-2014
A. N. Nesmeyanov Institute of Organoelement Compounds
2011
Ministry of Defence of Armenia
2010
In recent years, fungal infections have emerged as a significant health concern across veterinary species, especially in livestock such cattle, where diseases can result considerable economic losses, well humans. particular, Aspergillus notably flavus and versicolor, are opportunistic pathogens that pose threat to both animals This study focuses on the synthesis antifungal evaluation of novel 9-fluorenylmethoxycarbonyl (Fmoc)-protected 1,2,4-triazolyl-α-amino acids their dipeptides, designed...
An approach to the synthesis of a series novel, enantiomerically pure analogs β-hydroxy-α-amino acids is reported.
ABSTRACT Antimicrobial resistance represents a significant global health threat, prompting the exploration of alternative therapeutic strategies. peptides (AMPs) and lipopeptides are promising candidates due to their unique ability disrupt bacterial cell membranes through mechanisms distinct from conventional antibiotics. These typically enhanced by motifs involving cationic amino acids, positive charge, aromatic residues. Additionally, conjugation acyl chains N‐terminus AMPs has been shown...
This study presents the chemical synthesis, purification, and characterization of a novel non-natural synthetic amino acid. The compound was synthesized in solution, purified, characterized using NMR spectroscopy, polarimetry, melting point determination. Dynamic Light 22 Scattering (DLS) analysis demonstrated its ability to form aggregates with an average size 391 nm, extending low micrometric sizes. Furthermore, cellular biological assays revealed enhance fibroblast cell growth,...
This study presents the chemical synthesis, purification, and characterization of a novel non-natural synthetic amino acid. The compound was synthesized in solution, purified, characterized using NMR spectroscopy, polarimetry, melting point determination. Dynamic Light Scattering (DLS) analysis demonstrated its ability to form aggregates with an average size 391 nm, extending low micrometric range. Furthermore, cellular biological assays revealed enhance fibroblast cell growth, highlighting...
Abstract Mono‐ and dihomoallylamines serve as convenient precursors for the preparation of 6‐substituted piperidine‐2,4‐diones. This transformation is based, on one hand, a simple well‐known halocyclocarbamation reaction proceeding by addition source cationic halogen to N ‐Boc‐protected homoallylamines and, other, new enolate‐isocyanate rearrangement that proceeds action strong bases bromocyclocarbamates. A set racemic were prepared allylboration nitriles or primary amides with...
A two-dimensional single-cell based model for cell divisions and tissue growth.
A new and convenient synthesis of optically pure (<italic>S</italic>)-2-amino-5-[aryl]pent-4-ynoic acids (alkynylated amino acids) is reported.
Abstract Herein we report the synthesis of a variety new enantiomerically enriched non‐protein ( S )‐α‐amino acids based on reaction generating carbon‐carbon bonds in side chain group amino acid moiety with high chemical yields and optical purity using Suzuki. As initial synthon, Schiff base Ni(II) complex chiral auxiliary )‐BPB (N‐benzyl proline benzophenone) 4‐bromo‐ L ‐phenylalanine was used. The final complexes were decomposed aqueous HCl isolated excellent enantioselectivities (>99%...
Abstract Enantiomerically enriched phosphorus‐containing α‐amino acids were synthesized by the method of asymmetric synthesis, using Ni(II) square planar complex dehydroalanine as an initial complex. After acidic hydrolysis, with high enantiomeric purity isolated. At next stage, Fmoc derivatives obtained ( ee >99 %). Synthesized and their exhibited anticholinesterase activity, inhibiting AChE BuChE. same time, antiacetylcholinesterase activity ranged from 14 to 77 %, S...
Starting from commercially available building blocks a variety of enantiomerically pure (S)-2-amino-4-enoic acids has been synthesized by the Heck reaction using Ni-(S)-BPB {Nickel-N-[(S)-benzylprolyl]aminobenzophenone} as chiral auxiliary. The reactions proceeded in very good yields and with high E-selectivity.
A new family of Cu(II) and Ni(II) salen complexes was synthesized fully characterized through various physicochemical methods. Their catalytic activity evaluated in the phase transfer Cα-alkylation reaction Schiff bases D,L-alanine ester benzaldehyde derivatives. It found that introduction a chlorine atom into ortho- para-positions phenyl ring substrate resulted an increase both chemical yield asymmetric induction (ee 66-98%). The highest enantiomeric excess achieved case complex based on...
Enantiomerically enriched (<italic>S</italic>)-α-amino acids were obtained. As the initial complex, Schiff base Ni(<sc>ii</sc>) complexes used. The target disassembled and amino isolated with excellent enantioselectivities.
An efficient method for the asymmetric synthesis of a-amino acids, containing furyl- and thiophenyl-substituted triazoles in their side-chain, is reported. The strategy relies on Michael addition 3,4,5-substituted 1,2,4-triazoles to C=C bond chiral NiII complexes Schiff base formed from dehydroamino acids (dehydroalanine (E + Z)-dehydroaminobutyric acid) auxiliaries, i. e. (S)-2-N-(N0-benzylprolyl)aminobenzophenone (S)-2-N- (N0-2-chlorobenzylprolyl) aminobenzophenone. reactions proceeded...
Abstract Ni(II) complex of the Schiff base chiral auxiliary (S)-2-N-(N′-benzylprolyl)aminobenzophenone (BPB) and dehydroalanine as initial in addition reaction was investigated. The obtained four new derivatives α-alanine were investigated inhibitors aldose reductase. Only one them: (S)-2-amino-3-[(4-methylbenzyl)amino]propanoic acid showed activity. It becomes a reason for studying patterns biological activity structure α-amino acids. results docking analysis indicated that demonstrated...