A5074623085- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Plant nutrient uptake and metabolism
University of Oxford
2022-2023
Amplification of the mitotic kinase Aurora A or loss its regulator protein phosphatase 6 (PP6) have emerged as drivers genome instability. Cells lacking PPP6C, catalytic subunit PP6, amplified activity, and we show here, enlarged spindles which fail to hold chromosomes tightly together in anaphase, causing defective nuclear structure. Using functional genomics shed light on processes underpinning these changes, discover synthetic lethality between PPP6C kinetochore NDC80. We find that NDC80...
Abstract Amplification of the mitotic kinase Aurora A or loss its regulator protein phosphatase 6 (PP6) have emerged as drivers genome instability. Cells lacking PPP6C, catalytic subunit PP6, amplified activity and we show here, enlarged spindles which fail to hold chromosomes tightly together in anaphase, causing defective nuclear structure. Using functional genomics shed light on processes underpinning these changes, discover synthetic lethality between PPP6C kinetochore NDC80. We find...