A5012934075- Shoulder Injury and Treatment
- Tendon Structure and Treatment
- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Diabetic Foot Ulcer Assessment and Management
- Sports injuries and prevention
- Hip and Femur Fractures
- Elbow and Forearm Trauma Treatment
- Knee injuries and reconstruction techniques
- Orthopedic Surgery and Rehabilitation
- Total Knee Arthroplasty Outcomes
- Adhesion, Friction, and Surface Interactions
- Bone and Dental Protein Studies
- Pelvic and Acetabular Injuries
- Tissue Engineering and Regenerative Medicine
- Bone health and treatments
- Bone and Joint Diseases
- Bone health and osteoporosis research
- Foot and Ankle Surgery
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Stroke Rehabilitation and Recovery
- Bone fractures and treatments
- Xenotransplantation and immune response
Cedars-Sinai Medical Center
2022-2025
Cedars-Sinai Kerlan-Jobe Institute
2022-2025
Orthopaedic Hospital
2024
Questions remain about whether circumferential labral reconstruction (CLR) using an iliotibial band (ITB) allograft can effectively restore the suction seal of hip.(1) CLR with ITB >6.5 mm would distractive stability force to that intact labrum. (2) achieve significantly superior compared <6.5 mm.Controlled laboratory study.A total 6 fresh-frozen pelves attached femurs (n = 12 matched hemipelves) from male donors were procured and dissected free all soft tissue, including hip capsule but...
Background: Even with the best conservative care, patients Charcot neuroarthropathy (CN) of foot and ankle often ulcerate, increasing their risk infection, amputation, death. Surgical fixation has been associated recurrent ulceration, potentially due to poor bone quality prone deformity ulceration. We propose midfoot beam reconstruction PMMA augmentation as a novel means improving fixation. Methods: A protocol was developed create characteristic CN fragmentation both visually...
Tendons and ligaments have a poor innate healing capacity, yet account for 50% of musculoskeletal injuries in the United States. Full structure function restoration postinjury remains an unmet clinical need. This study aimed to assess application novel three dimensional (3D) printed scaffolds induced pluripotent stem cell-derived mesenchymal cells (iMSCs) overexpressing transcription factor Scleraxis (SCX, iMSC
Abstract Ulnar collateral ligament reconstruction (UCLR) is frequently performed among injured overhead-throwing athletes. One of the most common graft choices when performing a UCLR ipsilateral palmaris longus tendon (PL). The purpose this study was to investigate material properties aseptically processed cadaveric knee ligaments (kMCL) as potential source for and compare them gold standard PL autograft. Each kMCL sample subjected cyclic preconditioning, stress relaxation, load-to-failure...
In regenerative medicine, experimental animal models are commonly used to study potential effects of human cells as therapeutic candidates. Although some studies describe certain cells, such mesenchymal stromal (MSC) or primary hypoimmunogenic and therefore unable trigger strong inflammatory host responses, other report antibody formation immune rejection following xenotransplantation. Accordingly, the goal our was test cellular retention survival human-induced pluripotent stem cell...
Background: Osteoadsorptive fluorogenic sentinel 3 (OFS-3) is a recently described compound that contains bone-targeting bisphosphonate (BP) and cathepsin K (Ctsk)-triggered fluorescence signal. A prior study in murine Achilles repair model demonstrated its effectiveness at targeting the site of tendon-to-bone repair, but intrinsic effect this novel chaperone on healing has not been previously explored. We hypothesized application bisphosphonate-fluorophore cargo conjugate would affect...
Tendon injuries represent an ongoing challenge in clinical practice due to poor regenerative capacity, structure, and biomechanical function recovery of ruptured tendons. This study is focused on the assessment a novel strategy repair Achilles tendons Nude rat model using stem cell-seeded biomaterial.
Medial ulnar collateral ligament (mUCL) injury can cause significant pain and alter throwing mechanics. Common autograft options for mUCL reconstruction (UCLR) include the palmaris longus (PL) hamstring tendons. Allograft use may reduce donor site morbidity decrease function related to PL autografts.
Secreted protein acidic and rich in cysteine (SPARC) is the most abundant glycoprotein bone thought to play a critical role remodeling homeostasis. However, effect of SPARC relation gender exercise on quality not well understood. The purpose this study was quantify differences structural biomechanical properties between calvarial femoral from male female wild-type (WT) null (SPARC
Category: Basic Sciences/Biologics; Diabetes Introduction/Purpose: Even with the best conservative care, patients Charcot Neuroarthropathy (CN) of foot and ankle often ulcerate, increasing their risk infection, amputation, death. Surgical fixation has a 30% recurrent ulceration, likely due to poor host bone quality which is prone deformity recurrence subsequent ulceration. We propose midfoot beam reconstruction PMMA augmentation as novel means improving fixation. Methods: A protocol was...
Objectives: Background: Favorable patient-reported outcomes has been reported following circumferential labral reconstruction (CLR);however, there is a paucity on biomechanical data CLR. Purpose: To evaluate the role of CLR using iliotibial band (ITB) allograft restoration distractive stability force (suction seal), and to whether any correlation existed between ITB width after Hypothesis: 1) wider would restore level comparable intact labrum. 2) Wider achieve significantly superior when...