Objectives/Hypothesis Malignant otitis externa (MOE) is a rare disorder that not well studied in the inpatient setting. The Nationwide Inpatient Sample (NIS) database was utilized to analyze characteristics and predischarge outcomes of hospitalized MOE patients. Methods hospitalizations were identified 2002 2013 NIS. Patient demographics, length hospital stay, charges, concomitant diagnoses, treatment‐related procedures, complications, in‐hospital mortality rates examined, with comparisons...

Arterial ligation and embolization are treatment modalities indicated in severe refractory epistaxis. The purpose of this study was to examine temporal trends compare outcomes hospitalized epistaxis patients with or embolization.This retrospective cohort analysis utilized the 2008 2013 National Inpatient Sample identify admitted a primary diagnosis epistaxis, an associated procedure code for embolization.A total 1,813 cases met inclusion criteria, 57.1% undergoing ligation. During period,...

OBJECTIVE Observation and neurosurgical intervention for unruptured intracranial aneurysms (UIAs) in the elderly population is rapidly increasing. Cerebral aneurysm coiling (CACo) favored over cerebral clipping (CAC) patients, yet some individuals still undergo CAC. The cost-effectiveness of treating UIAs requires further exploration. Understanding effect on hospital charges length stay (LOS) as well perioperative mortality complications can shed light its economic impact. purpose this study...

Objective To compare comorbidities and in-hospital complications between elderly nonelderly patients undergoing vestibular schwannoma (VS) surgery. examine average length of stay (LOS) hospital charges among patients. Study Design Population-based inpatient registry analysis. Setting Academic medical center. Subjects Methods Retrospective analysis the National Inpatient Sample for VS surgery from 2002 to 2010: 4137 met inclusion criteria, with 519 (12.5%) in cohort (≥65 years). Outcomes (<65...

Autologous hematopoietic stem cell transplantation (auto-HSCT) has improved survival in patients with multiple myeloma (MM) and is increasingly used elderly patients. The aim of this study was to characterize compare in-hospital complications mortality after auto-HSCT younger (< age 65) versus (> MM utilizing the Nationwide Inpatient Sample. Over a 3-year period (2008 2010), 2209 were admitted US hospitals for auto-HSCT. median 59 years, 1650 (74.7%) than 65 559 (25.3%) or older. Overall,...

Although previous studies have reported increased perioperative complications among obstructive sleep apnea (OSA) patients undergoing any surgery requiring general anesthesia, there is a paucity of literature addressing the impact OSA on postoperative transsphenoidal (TSS) complications. The aim this study was to analyze outcomes in pituitary with OSA. Secondarily, we examined patient characteristics and comorbidities.Retrospective analysis.The 2002 2013 National Inpatient Sample queried for...

As the country ages, thyroidectomies can be expected to performed more frequently among elderly. In this study, we stratified patients by age explore demographics and complications of undergoing thyroidectomy.Retrospective study with a national database.Nationwide Inpatient Sample.A total 414,079 thyroidectomy cases from 2005 2013 were identified. Complications, outcomes, demographics, length stay, hospital charges evaluated into 4 cohorts: younger (<65 years), advanced (65-74 elderly (75-84...

Epistaxis is common in elderly patients, occasionally necessitating hospitalization for the management of severe bleeds. In this study, we aim to explore impact nasal packing versus nonpacking interventions (cauterization, embolization, and ligation) on outcomes complications epistaxis elderly.The 2008-2013 National Inpatient Sample was queried patients (≥65 years) with a primary diagnosis accompanying procedure codes anterior posterior or interventions.A total 8449 cases met inclusion...

Objectives/Hypothesis Although chronic obstructive pulmonary disease (COPD) is a common comorbidity in patients undergoing laryngeal cancer surgery, the impact of this setting not well established. In analysis, we used Nationwide Inpatient Sample (NIS) to elucidate COPD on outcomes after laryngectomy for cancer. Methods The NIS was queried admitted from 1998 2010 with who underwent total or partial laryngectomy. Patient demographics, type admission, length stay, hospital charges, and...

Objective: To create a longitudinal near-peer mentorship program for medical students applying to otolaryngology. Methods: A was designed based on needs analysis of senior students. Program objectives were (1) provide didactic education common otolaryngology consults, (2) facilitate resident-student networking, and (3) enable applicants meet other Senior residents matched with from across the United States series online small group meetings. Sessions included resident-designed didactics...

Skull base osteomyelitis may rarely present in the sphenoid bone or clivus without an otologic source. This is referred to as central skull (CSBO). Knowledge regarding CSBO limited case reports and small series. Here we a series further describe typical patient characteristics, clinical presentation, course associated with this rare infection.All patients treated at single academic tertiary care institution for from 2016 through 2020 were identified. Inclusion criteria included culture...

Liver disease (LD) often results in coagulation abnormalities that may predispose to more severe epistaxis. The purpose of this analysis was examine characteristics patients hospitalized for epistaxis with LD and explore the impact on patient outcomes.The 2002 2013 National Inpatient Sample queried cases a primary diagnosis Cases additional codes meeting Agency Healthcare Research Quality's definition were identified compared non-LD cohort.Out 39,879 inclusion criteria, 3.6% had LD....

Background and Objective: Relative to many other head neck cancers, sinonasal squamous cell carcinoma (SNSCC) is a rare malignancy of the with notably poor prognosis. Although it most common cavity, comprises only 3 5% all cancers. Treatment SNSCC classically entails surgical resection followed by adjuvant radiotherapy. A trend toward endoscopic over open tumor has resulted in fewer postoperative complications morbidity, unfortunately seemingly no significant improvement survival. Prognosis...

Abstract RNA-binding protein HuR (ELAVL1) is a master regulator of gene expression in human pathophysiology. Its dysregulation plays an important role many diseases. We hypothesized that Th2 inflammation asthma both mouse and human. To address this, we used model airway T cell–specific knockout model, distal lck-Cre HuRfl/fl, as well small molecule inhibitors peripheral blood-derived CD4+ cells. Peripheral cells were isolated from 26 healthy control subjects 45 asthmatics (36 type 2 high 9...

To quantify the prevalence of hospital admissions, financial impact, and trends in surgical procedure rates for AOM CAOM all ages before after 13-valent pneumococcal conjugate vaccine (PCV13) introduction.Retrospective analysis National Inpatient Sample (NIS) from 1998 to 2013 determine AOM/CAOM related admissions weighted frequencies International Classification Diseases, ninth revision (ICD-9) diagnoses. Prevalence procedures treat CAOM, cost admission, length stay, per day admission were...

e21533 Background: We aimed to evaluate post-gastrectomy outcomes in patients (pts) age ≥ 75 using the Nationwide Inpatient Sample (NIS), as population based data elderly pts are needed given increased incidence of gastric cancer aging population. Methods: used NIS database identify all admitted US hospitals for gastrectomy from 2005-2010. Outcomes and younger were compared. Results: identified 9455 pts, median was 68; 3022 (32%) group (age 75) 6433 (68%) 18–74. Elderly had more major...

Abstract RNA-binding protein human antigen R (HuR) is a master regulator of gene expression in pathophysiology. Our animal studies the past showed multiple critical roles for HuR regulating proinflammatory markers CD4+ T cells. We hypothesized plays an important role GATA3 and Th2 cytokines type 2 high asthma its inhibition impairs these inflammatory responses. Peripheral cells were isolated from 26 healthy controls 32 asthmatics (blood eosinophil ≥300 cells/μl or FeNO levels ≥25ppb)...

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