A5076732893- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Adsorption and biosorption for pollutant removal
- Phosphorus and nutrient management
- Phenothiazines and Benzothiazines Synthesis and Activities
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Quinazolinone synthesis and applications
- Advanced Synthetic Organic Chemistry
- CO2 Reduction Techniques and Catalysts
- Synthesis of Indole Derivatives
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Minerals Flotation and Separation Techniques
- Bioactive Compounds and Antitumor Agents
- Alkaloids: synthesis and pharmacology
- Enzyme Catalysis and Immobilization
- Chemical Synthesis and Characterization
- Chemical Reactions and Isotopes
- Sulfur-Based Synthesis Techniques
- Phosphorus compounds and reactions
- Synthesis and Reactivity of Heterocycles
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Oxidative Organic Chemistry Reactions
- Catalytic Cross-Coupling Reactions
Zhejiang Sci-Tech University
2024
Huazhong University of Science and Technology
2024
Sichuan Normal University
2024
Zhejiang University of Technology
2018-2022
Hangzhou Xixi hospital
2019
Abstract In the pursuit of clean pharmaceutical production, chemists in medicinal industry require access to new sustainable methodologies reduce and even eliminate pollution, which is mainly produced by overuse organic solvents during chemical synthesis active ingredients (APIs). this context, solvent‐free/less mechanochemical functionalization small molecules has gradually emerged as a powerful strategy for green modification APIs, bioactive compounds, functional materials. review, we...
A novel method to synthesize 4-alkylpyrimidines by the mechanochemical magnesium-mediated Minisci reaction of pyrimidine derivatives and alkyl halides has been reported. The process operates with a broad substrate scope excellent regioselectivity under mild conditions no requirement transition-metal catalysts, solvents, inert gas protection. practicality this protocol demonstrated up-scale synthesis, product derivatization, antimalarial drug pyrimethamine preparation.
The need for an operationally straightforward application of radical chemistry has led researchers to explore practical strategies obtain and trap radicals.
C3-alkenylated and C3-(hetero)arylated 1H-indazoles are privileged structural motifs in numerous pharmaceuticals. Direct C3-alkenylation C3-(hetero)arylation of have been significantly challenging because the inert nature this carbon center. Herein, we present an efficient mechanochemical strategy for palladium-catalyzed C–H/C–H cross-coupling to construct C3-heteroarylated using low-cost copper oxidants with satisfactory product yields broad functional group tolerance. The robustness...
Comprehensive Summary The implementation of divergent protein engineering on the natural transaminase Vf ‐ω‐TA led to development two effective mutants (M2 and M8), enabling enzymatic synthesis chiral amine precursors Rivastigmine Apremilast, respectively. evolution enzymes was guided by crystal structures a focused mutagenesis strategy, allowing them effectively address challenging ketone substrates with significant steric hindrance. Under optimized reaction parameters, transamination...
Artificial photoenzymes with novel catalytic modes not found in nature are high demand; yet, they also present significant challenges the field of biocatalysis. In this study, a chemogenetic modification strategy is developed to facilitate rapid diversification photoenzymes. This integrates site-specific chemical conjugation various artificial photosensitizers into natural protein cavities and iterative mutagenesis cell lysates. Through rounds directed evolution, prominent...
A mechanically-activated chemoselective Heck coupling for the synthesis of 3-vinylindazoles has been developed with aid catalytic amounts TBAB and NaBr as both dehalogenation restrainer grinding auxiliary. After tuning chemical conditions mechanical parameters, a series non-activated 3-bromoindazoles broad scope olefins worked well to give corresponding products in good excellent yields. further application this protocol was performed two-step mechanochemical Heck/Migita cross coupling,...
A mechanochemically Cu(<sc>ii</sc>)-catalyzed decarboxylative acylation of <italic>N</italic>-free indoles with O<sub>2</sub> as a terminal oxidant was developed for the mild synthesis 3-acylindoles.
A simple-to-prepare, environmentally friendly, efficient, and sustainable phosphate adsorbent was developed from iron oxide-modified coconut shell-activated carbon loaded with zirconium oxychloride (MAC@Zr). MAC@Zr characterized using SEM, EDS, XRD, XPS. The adsorption experiments showed that PO43- removal reached 100% in <10 min at an initial pH of 3.0, a concentration 10 mg(P)/L dosage 4 g/L. Importantly, exhibited outstanding selective for demonstrated anti-interference ability to...
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