A5016821586- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Synthesis and Reactivity of Heterocycles
- Electron Spin Resonance Studies
- Cyclopropane Reaction Mechanisms
- Synthesis and Biological Evaluation
Pohang University of Science and Technology
2017-2018
Government of the Republic of Korea
2018
A highly fluorescent, non-perturbing, pentacyclic adenine analog was designed, synthesized, incorporated into DNA and photophysical evaluated.
Herein, we describe an extended version of a fluorescence probe for detecting miRNAs through the novel application <sup>Py</sup>A-cluster system.
2'-deoxyfuranouridine derivatives presenting various aryl groups have been synthesized through Cu(I)-catalyzed intramolecular cyclizations. Moreover, corresponding pyrrolo-dC and both families of compounds thoroughly characterized using UV/vis fluorescence spectroscopy as well time-dependent density functional theory calculations. The photophysical characterization, show that our newly the important family high quantum yields (QYs) brightness values. Pyrrolo-dC derivative, 3a, shows an...
We have developed hybridization-sensitive fluorescent oligonucleotide probes that, in the presence of quencher strands, undergo efficient fluorescence quenching through formation partial DNA/DNA duplexes. In target RNA, rapid displacement strands results highly enhanced fluorescence.