A5061603359- Peroxisome Proliferator-Activated Receptors
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Cancer, Lipids, and Metabolism
- Cellular transport and secretion
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Drug Transport and Resistance Mechanisms
- Acute Myocardial Infarction Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Nitric Oxide and Endothelin Effects
- Cardiomyopathy and Myosin Studies
- Cognitive and developmental aspects of mathematical skills
- Microbial infections and disease research
- Neonatal and Maternal Infections
- Molecular Sensors and Ion Detection
- Musculoskeletal Disorders and Rehabilitation
- Medical and Biological Sciences
- Cholesterol and Lipid Metabolism
- Orthopedic Infections and Treatments
- Caveolin-1 and cellular processes
- Chemokine receptors and signaling
- Tendon Structure and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Musculoskeletal synovial abnormalities and treatments
Boston University
2010-2020
Mayo Clinic
2019-2020
Mayo Clinic in Florida
2020
John Wiley & Sons (United States)
2020
WinnMed
2020
Mayo Clinic in Arizona
2018
Edith Nourse Rogers Memorial Veterans Hospital
2011
Geriatric Research Education and Clinical Center
2011
Bedford VA Research Corporation
2010
University of Kansas
1949-1999
CD36 is a multifunctional protein that enhances cellular fatty acid (FA) uptake, key step in energy metabolism, and its dysregulation multiple tissue sites central to obesity-linked diabetes, risk factor for atherosclerosis. Although has been implicated FA uptake correlative way, the molecular mechanisms are not known. Their elucidation cells confounded by receptor-mediated of low-density lipoprotein competitive and/or contributive effects other proteins involved transport which include...
ABSTRACT Arthrofibrosis is a common complication following total knee arthroplasty caused by pathologic fibroblast activation and excessive collagen deposition around synovial joint leading to debilitating loss of motion. Treatment options are limited because the mechanisms remain be characterized. Dysregulation inflammatory cascade may lead communication between myofibroblasts immune cells triggering tissue metaplasia, described clinically as arthrofibrosis. We explored novel use celecoxib...
Membrane-bound proteins have been proposed to mediate the transport of long-chain FA (LCFA) through plasma membrane (PM). These proposals are based largely on reports that PM LCFAs can be blocked by a number enzymes and purported inhibitors LCFA transport. Here, using ratiometric pH indicator (2',7'-bis-(2-carboxyethyl)-5-(and-6-)-carboxyfluorescein acrylodated intestinal FA-binding protein-based dual fluorescence assays, we investigated effects nine putative transporter protein CD36 binding...
Aims Arthrofibrosis is a relatively common complication after joint injuries and surgery, particularly in the knee. The present study used previously described validated rabbit model to assess biomechanical, histopathological, molecular effects of mast cell stabilizer ketotifen on surgically induced knee contractures female rabbits. Methods A group 12 skeletally mature rabbits were randomly divided into two groups. One received subcutaneous (SQ) saline, second SQ injections. Biomechanical...
Abstract The dense formation of abnormal scar tissue after total knee arthroplasty results in arthrofibrosis, an unfortunate sequela inflammation. purpose this study was to use a validated rabbit model assess the effects on surgically‐induced joint contractures two combined pharmacological interventions: celecoxib (CXB) loaded implanted collagen membrane, and subcutaneously (SQ) injected ketotifen. Thirty rabbits were randomly divided into five groups. first group received no intervention...
Four adults with mild mental retardation were taught to sort based on what two pictures had in common and name each object features of pairs as well comply a series instructions the selectively. The criterion task was inspect sample pair, through deck 15 find those showing pair common, repeat pairs. They failed this continued fail even after supposedly relevant self-instruction. After being act they told themselves, self-instructed correctly sorted accordingly. Imperfect generalization by 2...
Journal Article Studies on Streptococci. I. Experimental Streptococcal Infections of the Chorio-Allantoic Membrane Embryonic Chick Get access Noble P. Sherwood, Sherwood From Departments Bacteriology and Pathology University Kansas School Medicine, Lawrence City, Search for other works by this author on: Oxford Academic PubMed Google Scholar H. R. Wahl, Wahl Catherine Colglazier, Colglazier Tom Hamilton, Hamilton Alan Jay The Infectious Diseases, Volume 84, Issue 1, January 1949, Pages...
We investigated the hypothesis that interactions of unesterified fatty acid (FA) with plasma membrane protein CD36 affect uptake oxLDL. Because binding natural FA to have not been systematically studied, we first characterized by biophysical method surface plasmon resonance (SPR). After covalently linking extracellular domain an SPR chip surface, aqueous (solubilized in cyclodextrin) was pulsed across generating association and dissociation curves. studied structurally different long chain...
Obesity has become a major public health concern and represents predisposition factor for the development of cardiovascular‐related disease, ischemic stroke, non‐insulin dependent diabetes mellitus. Deciphering molecular mechanisms ligand binding subsequent signaling plasma membrane “scavenger” proteins such as CD36, will provide new insights therapeutic interventions lipotoxicity, inflammation, disease associated with obesity. Upon CD36 activation, inflammatory often occurs, leading to an...
It has been proposed that alterations in retromer activity may play a role Alzheimer's disease. We evaluated amyloid precursor protein (APP) and Aβ production HEK 293 which disrupted by knockdown of Vps35, vacuolar sorting is an essential component the complex. Stable cell lines were generated transducing wild type cells with lentiviral vectors expressing either nonspecific shRNA or one two shRNAs targeting Vps35 mRNA. After several rounds selection, lysates harvested analyzed for mRNA to...
Cardiac troponin I (cTnI) is a key regulator of cardiomyocyte contraction. Phosphorylation cTnI at Ser22/23 mediated by protein kinase A, C, and G, associated with reduced Ca 2+ sensitivity myocardial In previous in vivo vitro studies, we showed that hypothermia/rewarming (rewarming shock) reduces the contraction due to phosphorylation. Rewarming shock was also found isolated cardiomyocytes; however, demonstrating relationship phosphorylation complicated varying viability after isolation....