Nicolas Reina

ORCID: 0000-0003-4059-9014
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About
Contact & Profiles
Research Areas
  • Orthopaedic implants and arthroplasty
  • Total Knee Arthroplasty Outcomes
  • Knee injuries and reconstruction techniques
  • Hip disorders and treatments
  • Orthopedic Infections and Treatments
  • Hip and Femur Fractures
  • Shoulder Injury and Treatment
  • Orthopedic Surgery and Rehabilitation
  • Pelvic and Acetabular Injuries
  • Bone fractures and treatments
  • Sports injuries and prevention
  • Elbow and Forearm Trauma Treatment
  • Osteoarthritis Treatment and Mechanisms
  • Lower Extremity Biomechanics and Pathologies
  • Shoulder and Clavicle Injuries
  • Cardiac, Anesthesia and Surgical Outcomes
  • Musculoskeletal Disorders and Rehabilitation
  • Tendon Structure and Treatment
  • Bone and Joint Diseases
  • Management of metastatic bone disease
  • Anesthesia and Pain Management
  • Bone health and treatments
  • Clinical practice guidelines implementation
  • Foot and Ankle Surgery
  • Mesenchymal stem cell research

Hôpital Paule de Viguier
2015-2024

Centre Hospitalier Universitaire de Toulouse
2015-2024

Université Toulouse III - Paul Sabatier
2015-2024

AMIS - Laboratoire d'anthropologie moléculaire et imagerie de synthèse
2015-2024

Université de Toulouse
2021-2024

Centre National de la Recherche Scientifique
2015-2024

Hôpital Purpan
2011-2024

Institut de Recherche en Informatique de Toulouse
2021-2023

Hôpital des Enfants
2010-2023

Mayo Clinic
2017-2022

Concurrent hip and spine pathologies can alter the biomechanics of spinopelvic mobility in primary total arthroplasty (THA). This study examines how differences pelvic orientation patients with fusions increase risk dislocation after THA.We identified 84 (97 THAs) between 1998 2015 who had undergone spinal fusion prior to THA. Patients were stratified into three groups depending on length lumbar whether or not sacrum was involved. Mean age 71 years (40 87) 54 (56%) female. The mean body mass...

10.1302/0301-620x.101b2.bjj-2018-0754.r1 article EN The Bone & Joint Journal 2019-01-31

Under caloric restriction, bone marrow adipocytes (BM-Ads) do not decrease in size compared to white adipocytes, suggesting they harbor unique metabolic properties. We compare human primary BM-Ads with paired subcutaneous (SC-Ads) using proteomic and lipidomic approaches. find that, although SC-Ads share similar morphological features, possess distinct lipid metabolism. Although BM-Ad shows enrichment proteins involved cholesterol metabolism, correlating increased free content, lipolysis...

10.1016/j.celrep.2019.12.089 article EN cc-by Cell Reports 2020-01-01

Chondrosarcomas are primary cancers of cartilaginous tissue with highly contrasting prognoses. These tumors defined by recurrent mutations in the IDH genes and other genetic alterations including inactivation CDKN2A COL2A1; however, these have no clinical value. Here we use multi-omics molecular profiles from a series cartilage find an mRNA classification that identifies two subtypes chondrosarcomas balance tumor differentiation cell cycle activation. The microRNA reveals importance loss...

10.1038/s41467-019-12525-7 article EN cc-by Nature Communications 2019-10-11

The significance of weight in the indications for unicompartmental knee replacement (UKR) is unclear. Our hypothesis was that does not affect long-term rate survival UKRs. We undertook a retrospective study 212 UKRs at mean follow-up 12 years (7 to 22). patients were distributed according body mass index (BMI; < vs ≥ 30 kg/m 2 ) and (< 82 kg). Kaplan-Meier survivorship analysis performed ten-year rates compared between sub-groups. Multimodal regression determined impact various...

10.1302/0301-620x.95b8.31370 article EN The Bone & Joint Journal 2013-08-01

Aims Radial head arthroplasty (RHA) may be used in the treatment of non-reconstructable radial fractures. The aim this study was to evaluate mid-term clinical and radiographic results RHA. Patients Methods Between 2002 2014, 77 RHAs were implanted 54 men 23 women with either acute injuries (54) or traumatic sequelae (23) a fracture head. Four designs RHA used, including Guepar (Small Bone Innovations (SBi)/Stryker; 36), Evolutive (Aston Medical; 24), rHead RECON (SBi/Stryker; ten) STANDARD...

10.1302/0301-620x.99b9.bjj-2016-1043.r2 article EN The Bone & Joint Journal 2017-08-31

Background: Anterior cruciate ligament (ACL) reconstruction with a quadrupled semitendinosus (ST4) graft is an evolution of the standard technique 2 hamstring tendons (semitendinosus + gracilis [STG]). However, there no published comparison how well these types grafts are incorporated into bone tunnels. Because ST4 shorter, less material inside Purpose: To use magnetic resonance imaging (MRI) to compare incorporation in tibial tunnels 1 year after ACL either STG or graft. Study Design:...

10.1177/0363546517733472 article EN The American Journal of Sports Medicine 2017-10-24

ABSTRACT Arthrofibrosis is a common complication following total knee arthroplasty caused by pathologic fibroblast activation and excessive collagen deposition around synovial joint leading to debilitating loss of motion. Treatment options are limited because the mechanisms remain be characterized. Dysregulation inflammatory cascade may lead communication between myofibroblasts immune cells triggering tissue metaplasia, described clinically as arthrofibrosis. We explored novel use celecoxib...

10.1002/jor.24441 article EN Journal of Orthopaedic Research® 2019-08-14
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