A5083385194- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- HIV-related health complications and treatments
Northwest University
2023
Viruses are intracellular parasites which lack their own metabolism, so they must hijack host cell metabolic machinery in order to increase the production of energy, proteins, fats, and genetic material necessary replicate. Using murine herpesvirus 68 (MHV-68) as a model system understand how similar human gammaherpesviruses cause cancer, we profiled changes that occur during lytic MHV-68 infection replication.
ABSTRACT Oncogenic virus infections are estimated to cause ∼15% of all cancers. Two prevalent human oncogenic viruses members the gammaherpesvirus family: Epstein Barr Virus (EBV) and Kaposi’s Sarcoma Herpesvirus (KSHV). We use murine herpesvirus 68 (MHV-68), which shares significant homology with KSHV EBV, as a model system study lytic replication. Viruses implement distinct metabolic programs support their life cycle, such increasing supply lipids, amino acids, nucleotide materials...