A5079289829- Microbial Natural Products and Biosynthesis
- Oxidative Organic Chemistry Reactions
- Free Radicals and Antioxidants
- Carbohydrate Chemistry and Synthesis
- Electrochemical Analysis and Applications
- Chemistry and Chemical Engineering
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Radical Photochemical Reactions
- Crystallization and Solubility Studies
- Microbial Metabolic Engineering and Bioproduction
- Sustainability in Higher Education
- Catalytic C–H Functionalization Methods
- Enzyme Catalysis and Immobilization
- Electrochemical sensors and biosensors
- Biochemical and biochemical processes
- Marine Sponges and Natural Products
- Plant biochemistry and biosynthesis
- Chemical Safety and Risk Management
- Analytical Chemistry and Sensors
- Chemical Synthesis and Analysis
- Lipid metabolism and biosynthesis
- Metal complexes synthesis and properties
- Sulfur-Based Synthesis Techniques
- Environmental remediation with nanomaterials
University of Groningen
2012-2025
University of Gothenburg
2019-2020
Slovak University of Technology in Bratislava
1984-2017
Comenius University Bratislava
2008-2010
Iron nanoparticles were prepared by the reduction of central Fe(II) ion in coordination compounds with amino acid ligands. The anion used as a ligand acted reducing agent. Conditions for very mild; temperature did not exceed 52°C, and optimum pH was between 9.5 9.7. metal iron precipitated mirror on flask or colloid water. Identification product carried out measuring UV/VIS spectra oxidized oxygen yielding mixture oxides. Oxidation Fe(0) to took several seconds under air. size properties...
Mycobacterium tuberculosis synthesizes a thick cell wall comprised of mycolic acids (MA), which are foreign antigens for human T cells. T-cell clones from multiple donors were used to determine the fine specificity MA recognition by αβ Most CD1-presented lipid contain large hydrophilic head groups carbohydrates or peptides that dominate patterns specificity. diverges consensus antigen motif in it lacks group. Using forms natural and synthetic MA-specific T-cells with different receptors, we...
The nitrogen-nitrogen (N-N) bond motif comprises an important class of compounds for drug discovery. Synthetic methods are primarily based on the modification N-N or N=N precursors, whereas selective direct coupling offer advantages in terms atom economy and sustainability. In this context, enzymes such as piperazate synthases (PZSs), which naturally catalyze cyclization L-N5-hydroxyornithine to cyclic hydrazine L-piperazate, may allow expansion current narrow range chemical approaches...
A mechanistically divergent method is described that, employing a commercially available hypervalent iodine(III) reagent, generates alkoxy radicals from 1°, 2°, and 3° alcohols allows their use in the functionalization of C(sp3)-H C(sp2)-H bonds. This visible-light photoredox catalysis produces alkyl ethers via 1,5/6-hydrogen atom transfer or aryl 1,5-addition. mild methodology provides practical strategy for synthesis acetals, orthoesters, tetrahydrofurans, chromanes.
In archaea, the membrane phospholipids consist of isoprenoid hydrocarbon chains that are ether-linked to a sn-glycerol1-phosphate backbone. This unique structure is believed be vital for adaptation these micro-organisms extreme environments, but it also reflects an evolutionary marker distinguishes archaea from bacteria and eukaryotes. CDP-archaeol central precursor polar head group attachment. We examined various bacterial enzymes involved in attachment L-serine glycerol as groups their...
In Mycobacterium tuberculosis, mycolic acids and their glycerol, glucose, trehalose esters ("cord factor") form the main part of mycomembrane. Despite first isolation almost a century ago, full stereochemical evaluation is lacking, as scalable synthesis required for accurate immunological, including vaccination, studies. Herein, we report an efficient, convergent, gram-scale four stereo-isomers acid its glucose ester. Binding to antigen presenting protein CD1b T cell activation studies are...
Fungal aromatic prenyltransferases are a family of biosynthetic enzymes that catalyze the prenylation range substrates during biosynthesis bioactive indole alkaloids, diketopiperazines, and meroterpenoids. Their broad substrate scope soluble nature make these particularly adept for applications in biocatalysis; example, enzymatic derivatization drugs improves their bioactivity. Here, we investigated four putative from lichen-forming fungi, an underexplored group organisms produce more than...
An efficient catalytic one-pot synthesis of TBDMS-protected diacylglycerols has been developed, starting from enantiopure glycidol. Subsequent migration-free deprotection leads to stereo- and regiochemically pure diacylglycerols. This novel strategy applied the a major Mycobacterium tuberculosis phospholipid, its desmethyl analogue, platelet activating factor.
An efficient asymmetric synthesis of cyclo-archaeol and β-glucosyl is presented employing catalytic conjugate addition epoxide ring opening as the key steps. Their occurrence in deep sea hydrothermal vents has been confirmed by chromatographic comparison with natural samples.
The continuous emergence of antimicrobial resistance is causing a threat to patients infected by multidrug-resistant pathogens. In particular, the clinical use aminoglycoside antibiotics, broad-spectrum antibacterials last resort, limited due rising bacterial resistance. One major mechanisms in Gram-positive and Gram-negative bacteria phosphorylation these amino sugars at 3'-position O-phosphotransferases [APH(3')s]. Structural alteration antibiotics would be an obvious strategy tackle this...
Abstract Asymmetric addition of Grignard reagents to cyclohexenone, catalyzed by ferrocene diphosphanes, afforded chiral magnesium enolates. These enolates reacted in a one‐pot arrangement with N ‐benzylidenetoluenesulfonamide give β‐amino carbonyl compounds three contiguous stereocenters. Two major diastereoisomers ( dr = 60:40) product enantioselectivities up 95 % ee were separated flash chromatography.
Abstract Aroma and flavor profile of MD2 pineapple variety was investigated. Fruits imported from different geographical regions (Costa Rica, Puerto Rico) were labeled as an organic food. Characteristic volatile non-volatile compounds obtained by hydro-distillation direct percolation identified quantified gas chromatography-mass spectroscopy (GC/MS). At least 22 components in percolated extract (or 17 distillate) detected according to their mass spectra retention time. Relative concentration...
This guidebook aims to improve lab users’ everyday practices become more sustainable. Specifically, this provides practical suggestions on how effectively use instruments and resources acquire data. We provide advice labs covering disciplines such as biology, chemistry, computational science, engineering, life sciences, materials medicine, pharmacy, physics. As every is different, it may occur that alternative measures are required, be outdated or not applicable, sometimes laboratories able...
ABSTRACT Fungal DMATS-type aromatic prenyltransferases are a family of biosynthetic enzymes that catalyze the prenylation range substrates during biosynthesis bioactive indole alkaloids, diketopiperazines, and meroterpenoids. Together with their broad substrate scope soluble nature, this makes particularly adept for applications in biocatalysis, example to derivatize drug leads improve bioactivity. Here, we investigated four putative from lichen-forming fungi, an underexplored group...
This guidebook aims to improve lab users’ everyday practices become more sustainable. Specifically, this provides practical suggestions on how effectively use instruments and resources acquire data. We provide advice labs covering disciplines such as biology, chemistry, computational science, engineering, life sciences, materials medicine, pharmacy, physics. As every is different, it may occur that alternative measures are required, be outdated or not applicable, sometimes laboratories able...
The echinocandins represent the most recent class of antifungal drugs. Previous structure-activity relationship studies on these lipopeptides have relied mainly upon semisynthetic derivatives due to their complex chemical structures. A successful strategy for rapid enantioselective synthesis branched fatty acid chain caspofungin and analogues was developed synthesize several simplified caspofungin. specific minimum inhibitory activity each mimic determined against a panel Candida strains....
Atom transfer radical addition (ATRA), cyclization (ATRC), and polymerization (ATRP) are valuable synthetic methods for the functionalization of olefins. With advent photoredox catalysis, visible‐light became a popular tool initiation these reactions. We have developed protocol that enables easy access to distally functionalized pyrrolidines employing blue‐light mediated atom [3+2] cyclization. The reaction is scalable, proceeds at very mild conditions. tolerates various functional groups,...
Abstract From M(II) [sbnd] NCO− - L systems [M(II) = Ni(II), Co(II); pyrazole (pz), 3,5-dimethylpyrazole (dmpz), 3,4,5-trimethylpyrazole (tmpz)] the following new solid compounds were prepared: Ni(NCO)2L4, Ni(NCO)2(tmpz)2, Ni(tmpz. NCO)2, Co(NCO)2(pz)4, and Co(NCO)2L2, where dmpz, tmpz. Spectroscopic magnetic data used for purpose of assigning probable structures to compounds. For tmpz, Ni(NCO)2(tmpz)2 polymeric with N-bridging NCO groups are accepted, in case 1:4 two molecules out...
With the developments in high performance chromatography and mass spectrometry, analysis of complex mixtures closely related triacylglycerols has come within reach. Currently, however, availability chemically pure is limited, mainly due to lack efficient synthetic methods that allow their synthesis. Here, we report an operationally simple three‐step synthesis enantiopure with yields ranging from 79 92%, tolerates a broad range saturated unsaturated fatty acids. Furthermore, developed...