A5088740945- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Fungal Infections and Studies
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- Virology and Viral Diseases
- Antifungal resistance and susceptibility
- Mycobacterium research and diagnosis
- Toxoplasma gondii Research Studies
- Biosimilars and Bioanalytical Methods
- Microbial infections and disease research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Plant Pathogens and Fungal Diseases
- HIV/AIDS oral health manifestations
- Thermal Regulation in Medicine
- Immune cells in cancer
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- COVID-19 and healthcare impacts
- Inflammation biomarkers and pathways
- Whipple's Disease and Interleukins
- T-cell and B-cell Immunology
- Antimicrobial Peptides and Activities
Instituto Nacional de Enfermedades Respiratorias
2019-2024
University of Maryland, Baltimore
2024
Universidad Nacional Autónoma de México
2005-2021
National Institute of Cardiovascular Diseases
2020
There is still a need for safe, efficient, and low-cost coronavirus disease 2019 (COVID-19) vaccines that can stop transmission of severe acute respiratory syndrome 2 (SARS-CoV-2). Here we evaluated vaccine candidate based on live recombinant Newcastle virus (NDV) expresses stable version the spike protein in infected cells as well surface viral particle (AVX/COVID-12-HEXAPRO, also known NDV-HXP-S). This be grown embryonated eggs at low cost, similar to influenza vaccines, it administered...
Abstract There is still a need for safe, efficient and low-cost coronavirus disease 2019 (COVID-19) vaccines that can stop transmission of severe acute respiratory syndrome 2 (SARS-CoV-2). Here we evaluated vaccine candidate based on live recombinant Newcastle virus (NDV) expresses stable version the spike protein in infected cells as well surface viral particle (AVX/COVID-12-HEXAPRO, also known NDV-HXP-S). This be grown embryonated eggs at low cost similar to influenza it administered...
Bats belong to a wide variety of species and occupy diversified habitats, from cities the countryside. Their different diets (i.e., nectarivore, frugivore, insectivore, hematophage) lead Chiroptera colonize range ecological niches. These flying mammals exert an undisputable impact on both ecosystems circulation pathogens that they harbor. Pneumocystis are recognized as major opportunistic fungal which cause life-threatening pneumonia in severely immunocompromised or weakened mammals....
Abstract Background Histoplasma capsulatum and Pneumocystis organisms cause host infections primarily affecting the lung tissue. H. is endemic in United States of America Latin American countries. In special environments, commonly associated with bat bird droppings. -host specificity has been studied laboratory animals, its ability to be harboured by wild animals remains as an important issue for understanding spread this pathogen nature. Bats infected or spp. have found, mammal serving a...
Tuberculosis (TB) is one of the highest infectious burdens worldwide. An excess inflammation and inadequate antioxidant defense mechanisms are believed to lead chronic lung damage in tuberculosis (TB). However, circulating metabolites do not always replicate lung-associated biomarkers that define pathobiology disease. The objective this study was determine utility exhaled breath condensate (EBC), a non-invasive straightforward sample, evaluate alveolar space-derived redox state inflammation....
Three isolates of Histoplasma capsulatum were identified from mice lung, liver, and spleen inoculated with soil samples the X hotel's ornamental potted plants that had been fertilized organic material known as compost. The presence H. in original compost was detected using dot-enzyme-linked immunosorbent assay. Nested-PCR, a specific protein Hcp100 coding gene sequence, confirmed fungal identification associated an unusual histoplasmosis outbreak Acapulco. Although, diversity between isolate...
Severe inflammatory responses are associated with the misbalance of innate and adaptive immunity. TLRs, NLRs, cytokine receptors play an important role in pathogen sensing intracellular control, which remains unclear COVID-19. This study aimed to evaluate IL-8 production blood cells from COVID-19 patients a two-week follow-up evaluation. Blood samples were taken at admission (t1) after 14 days hospitalization (t2). The functionality TLR2, TLR4, TLR7/8, TLR9, NOD1, NOD2 IL-12 IFN-γ was...
Histoplasma capsulatum and Pneumocystis jirovecii are respiratory fungal pathogens that principally cause pulmonary disease. Coinfection with both is scarcely reported. This study detected this coinfection using specific molecular methods for each fungus in the bronchoalveolar lavage (BAL) of patients from a tertiary care hospital.BAL samples 289 hospitalized were screened by PCR markers H. (Hcp100) P. (mtLSUrRNA mtSSUrRNA). The presence these was confirmed generated sequences marker....
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SUMMARY Histoplasma capsulatum was sampled in lungs from 87 migratory Tadarida brasiliensis bats captured Mexico ( n =66) and Argentina =21). The fungus screened by nested-PCR using a sensitive specific Hcp100 gene fragment. This molecular marker detected 81·6% [95% confidence interval (CI) 73·4–89·7] of all bats, representing 71 amplified bat lung DNA samples. Data showed T. infection rate 78·8% (95% CI 68·9–88·7) 90·4% 75·2–100) those Argentina. Similarity with the H. sequence reference...
Abstract Background The global inequity in coronavirus disease 2019 (COVID-19) vaccine distribution, primarily affecting low- and middle-income countries (LMICs), highlights the urgent need for innovative cost-effective technologies to address availability disparities. This is crucial achieving sustaining widespread immunity protecting vulnerable populations during future booster campaigns. Methods To this need, we conducted a phase II clinical trial evaluating safety immunogenicity of...
Abstract Background The urgent need for safe, effective, and economical coronavirus disease 2019 (COVID-19) vaccines, especially booster campaigns targeting vulnerable populations, prompted the development of AVX/COVID-12 vaccine candidate. AVX/COVD-12 is based in a Newcastle virus La Sota (NDV-LaSota) recombinant viral vector. This expresses stabilized version spike protein severe acute respiratory syndrome 2 (SARS-CoV-2), specifically ancestral Wuhan strain. study aimed to assess its...
Childhood tuberculosis (TB) is a significant public health problem and the ninth leading cause of death worldwide. Progression Mycobacterium infection to active disease depends on mycobacterial virulence, environmental diversity, host susceptibility immune response. In children, malnutrition immaturity system contribute an inadequate Coinfections, though rarely described in TB, might be associated with deficiencies. Here, we describe immunological evaluation eight pediatric patients infected...
Histoplasmosis and pneumocystosis co-infections have been reported mainly in immunocompromised humans wild animals. The immunological response to each fungal infection has described primarily using animal models; however, the host concomitant is unknown. present work aimed evaluate pulmonary of patients with pneumonia caused either by Histoplasma capsulatum, Pneumocystis jirovecii, or their co-infection. We analyzed collectin cytokine patterns 131 bronchoalveolar lavage samples, which...
Pulmonary dysfunction is an underestimated complication in tuberculosis (TB) infection, affecting quality of life (QoL). Although respiratory function tests objectively reflect lung disturbances a specific moment, predictors illness severity at the time diagnosis are still lacking.We measured serum pro-inflammatory cytokines (TNF-α and IL-8), eicosanoids (PGE2, LTB4, RvD1, Mar1, LXA4), marker tissue damage (cell-free nucleosomes), indicators redox status (malonaldehyde, 8-isoprostane, total...
There is a sex bias in tuberculosis’s severity, prevalence, and pathogenesis, the rates are higher men. Immunological physiological factors fundamental contributors to development of disease, sex-related could play an essential role making women more resistant severe forms disease. In this study, we evaluated sex-dependent differences inflammatory markers. Serum samples were collected from 34 patients diagnosed with pulmonary TB (19 male 15 female) 27 healthy controls (18 9 female)....
Abstract The mycosis histoplasmosis is also considered a zoonosis that affects humans and other mammalian species worldwide. Among the wild mammals predisposed to be infected with etiologic agent of histoplasmosis, bats are relevant because they reservoir Histoplasma species, play fundamental role in maintaining spreading fungal propagules environments since infective mycelial phase grows their accumulated guano. In this study, we detected presence organ samples randomly captured urban areas...