A5075240740- Nanoparticle-Based Drug Delivery
- Natural Antidiabetic Agents Studies
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Nigella sativa pharmacological applications
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Cancer-related Molecular Pathways
- Cognitive Radio Networks and Spectrum Sensing
- Gut microbiota and health
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Pediatric Urology and Nephrology Studies
- Diverse Scientific Research Studies
- Cancer, Hypoxia, and Metabolism
- Ethnobotanical and Medicinal Plants Studies
- Cholesterol and Lipid Metabolism
- Immune Cell Function and Interaction
- Medicinal Plants and Neuroprotection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Wireless Communication Networks Research
- Cancer Treatment and Pharmacology
- Speech and Audio Processing
Morehouse School of Medicine
2016-2025
Armed Forces Medical College
2022-2025
Dr. Rajendra Prasad Central Agriculture University
2025
Gyan Vihar University
2015-2024
Institute of Medical Sciences
2019-2024
Banaras Hindu University
2024
Savitribai Phule Pune University
2024
Max Super Speciality Hospital
2023
Sri Sathya Sai Institute of Higher Learning
2022
Command Hospital
2021
Resveratrol (RES) is the most effective natural products used for treatment of a variety cancers. In this study, we tested effect RES in enhancing efficacy docetaxel (DTX) prostate cancer (PCa) cells. The C4-2B and DU-145 cell lines were treated with RES, DTX combination followed by evaluating apoptosis cycle progression. combined drug up-regulates pro-apoptotic genes (BAX, BID, BAK), cleaved PARP down regulates anti-apoptotic (MCL-1, BCL-2, BCL-XL) promoting apoptosis. cells up regulated...
Abstract Pancreatic cancer (PC) is one of the deadliest cancers and remains a major challenge due to its invasive metastatic nature. Increased levels CCR5 CCL5 have established indicators for disease status in various cancers, including PC. However, their role invasion metastasis PC not known. Here we conducted immunohistochemistry tissues found elevated epithelial staining compared non-neoplastic. In vitro experiments, such as flow cytometry, immunofluorescence western blotting with human...
The folate receptor (FR) is a valued target that highly expressed in various cancers, which will expedite the development of ligand-receptor binding based cancer therapeutics. In present investigation, through tissue microarray analysis, we report higher levels expression prostate (PCa) derived from patients, were minimal normal tissue. For folate-receptor targeted therapy PCa, generated novel planetary ball milled (PBM) nanoparticles (NPs) encapsulated with resveratrol (RES), and...
Docetaxel is the most commonly used chemotherapeutic agent to target androgen signaling in metastatic prostate cancer (PCa); however, prolonged treatment with docetaxel results drug-resistant cells. Combination therapies have potential of increasing effectiveness drug as well decreasing side effects. Curcumin a nontoxic organic compound multifaceted chemopreventive potential. In this study, we evaluated whether curcumin can reinforce effect on PCa The cell lines DU145 and PC3 were treated...
Toxicity and the development of resistance by cancer cells are impediments for docetaxel (DTX), a primary drug treating prostate (PCa). Since combination DTX with natural compounds can increase its effectiveness reducing toxic concentrations, we evaluated thymoquinone (TQ) determined cytotoxicity against PCa (DU145 C4-2B). This combination, in concentration-dependent manner, resulted synergistic apoptosis comparison to either or TQ alone. In addition, inhibition cell survival pathways...
Breast cancer (BrCa) is the most commonly diagnosed and second leading cause of cancer-related death in women. Alarming increases cases quests for more effective treatment BrCa. As chemotherapeutic drugs are associated with drug resistance, relapse, side effects, scientists turning to agents efficacy, such as natural compounds prevention Selected compounds, substances derived from living organisms, promote apoptosis inhibit metastasis, preventing growth. a result, these have potential...
Despite the improvement in survival for patients with liver cancer (LCa) recent decades, only one five survive 5 years after diagnosis. Thus, there is an urgent need to find new treatment options improve patient survival. For various cancers, including LCa, chemokine CCL5 (RANTES) facilitates tumor progression and metastasis. Since function of CCR5/CCL5 interaction LCa cell proliferation migration poorly understood, present study was undertaken investigate role axis these processes. Flow...
Malaria, a major killer of mankind, apart from classical ague presentation, may present with respiratory manifestations. This be misdiagnosed and important time lost in instituting antimalarials leading to higher morbidity mortality. Present work was undertaken study the clinical presentations malaria special reference system evaluate effect such atypical presentation. One hundred slide positive cases were taken detailed for involvement. Response seen these associated complications (if any)...
Non-small cell lung cancer (NSCLC) presents a complex and diverse disease, exhibiting variations at individuals' cellular histological levels. This complexity gives rise to different subtypes genetic mutations, posing challenges for accurate diagnosis effective treatment. Nevertheless, continuous progress in medical research therapies is continually shaping the landscape of NSCLC management. The treatment has undergone significant advancements recent years, especially with emergence targeted...
Chemokines are involved in the homing of various cancer cells, including those ovarian (OvCa), to distant organs. They may also promote or inhibit progression and metastasis. Hypoxia, a common phenomenon malignant tumors, promotes cell proliferation regulated by HIF-1α. Hypoxia-induced genes metastasis-associated functions epithelial-to-mesenchymal transition (EMT).Tissue microarrays human OvCa showed elevated expression CX3CR1 HIF-1α compared normal their levels were higher adenocarcinoma...
This study examines the long-term effects of organic and inorganic fertilizers on soil sulphur (S) dynamics fractionation in rice-based cropping systems calcareous soils, addressing critical gaps understanding S distribution availability. The findings reveal that prolonged fertilization significantly influences content across various depths, with most pronounced increases available occurring at 30-45 cm, particularly plots treated compost. Compost amendments were especially effective...
Impact of the green revolution genes on rice and wheat productivity under rainfed environments has been debated since past few decades. Here we made an attempt to assess impact two major Rht B1 D1 grain yield drought stress. A total four recombinant inbred line (RIL) populations were analyzed for this objective including PBW343 × Muu, Kingbird, Kenyaswara Jal 95.4.3 Kachu/Kiritati/Kachu. These segregated either or both gene alleles. Our results revealed invariable non-association...
A BSTRACT Introduction: Vitamin D plays a crucial role in calcium assimilation, which is essential for the maintenance of robust and optimal bone health. The results studies on correlation between vitamin handgrip strength are varied. We conducted study to investigate levels diabetic patients. Methods: cohort 100 individuals diagnosed with diabetes were subjected an assessment anthropometric measurements levels. Additionally, their HbA1c levels, lipid profile, uric acid presence...
Abstract Breast cancer (BrCa) is the most diagnosed in women; it develops locally and then metastasizes to other organs. Due tumor heterogeneity, prevalence of drug resistance, disease recurrence, current therapy options are proving less effective for specific BrCa subtypes, such as triple-negative breast (TNBC). Therefore, treatment has shifted from a one-size-fits-all strategy more focused approach. In this study, we demonstrated folate receptor-based targeted delivery either curcumin...
Breast cancer (BrCa) is a heterogeneous and deadly affecting women, involving various pathways regulating the growth proliferation of cells. Upon diagnosis, BrCa typically treated according to molecular subtypes such as estrogen receptor (ER), progesterone (PR), or human epidermal factor 2 (HER2). In recent years, chemotherapy targeted therapy have improved 5-year survival rate for patients with receptor-positive BrCa. However, diagnosed triple-negative breast (TNBC) remain unsatisfactory....