A5016780821- interferon and immune responses
- Cell Adhesion Molecules Research
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- 3D Printing in Biomedical Research
- Protease and Inhibitor Mechanisms
- Cancer Cells and Metastasis
- RNA Research and Splicing
- TGF-β signaling in diseases
- Extracellular vesicles in disease
- Cancer Genomics and Diagnostics
- Hippo pathway signaling and YAP/TAZ
- Cancer Immunotherapy and Biomarkers
- Cellular Mechanics and Interactions
- Autophagy in Disease and Therapy
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Dynamic reciprocity between cellular components of the tumor microenvironment and cells occurs primarily through interaction soluble signals, i.e., cytokines produced by stromal to support cancer initiation progression regulating cell survival, differentiation immune functionality, as well migration death. In present study, we focused on analysis functional response non-small lung lines elicited treatment with some crucial factors which, at least in part, mimic stimulus exerted vivo...
Abstract On September 23–24 (2024) the 6th Workshop IRE on Translational Oncology, titled “Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies,” took place at IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused tumor organoids, bringing together leading experts from around world. A central challenge precision oncology is modeling dynamic ecosystem, which encompasses numerous elements that evolve spatially and...
Background Understanding how cancer signaling pathways promote an immunosuppressive program which sustains acquired or primary resistance to immune checkpoint blockade (ICB) is a crucial step in improving immunotherapy efficacy. Among the that can affect ICB response interferon (IFN) pathway may be both detrimental and beneficial. The sensor retinoic acid-inducible gene I (RIG-I) induces IFN activation secretion activated by actin cytoskeleton disturbance. regulatory protein hMENA, along...