A5067142599- Health and Medical Studies
- Advances in Oncology and Radiotherapy
- Nutrition, Genetics, and Disease
- Reproductive tract infections research
- Genomics and Rare Diseases
- Viral Infections and Outbreaks Research
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Viral Infections and Vectors
- Ethics in Clinical Research
- Urticaria and Related Conditions
- BRCA gene mutations in cancer
- RNA Research and Splicing
- Reproductive Physiology in Livestock
- Urinary Tract Infections Management
- Cancer Genomics and Diagnostics
- Reproductive System and Pregnancy
- Mosquito-borne diseases and control
- T-cell and B-cell Immunology
- Parasites and Host Interactions
- RNA modifications and cancer
- Immune Response and Inflammation
- Bladder and Urothelial Cancer Treatments
- Disaster Response and Management
- Public Health Policies and Education
Association for Jewish Studies
2023-2025
Marymount University
2023-2024
Duke University Hospital
2022
Duke Medical Center
2022
Duke University
2019-2021
University of Virginia
2016-2017
Phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) is a lipid kinase involved in endosome maturation that emerged from haploid genetic screen as being required for Ebola virus (EBOV) infection. Here we analyzed the effects of apilimod, PIKfyve inhibitor was reported to be well tolerated humans phase 2 clinical trials, its on entry and infection EBOV Marburg (MARV). We first found apilimod blocks infections by MARV Huh 7, Vero E6 primary human macrophage cells, with notable potency...
The 2014 outbreak of Ebola virus (EBOV) in Western Africa highlighted the need for anti-EBOV therapeutics. Clomiphene is a U.S. Food and Drug Administration (FDA)-approved drug that blocks EBOV entry infection cells significantly protects EBOV-challenged mice. As provided, clomiphene is, approximately, 60:40 mixture two stereoisomers, enclomiphene zuclomiphene. pharmacokinetic properties isomers vary, but both accumulate eye male reproductive tract, tissues which can persist. Here we...
Abstract Susceptibility to infectious diseases is determined by a complex interaction between host and pathogen. For infections with the obligate intracellular bacterium Chlamydia trachomatis, variation in immune activation disease presentation are regulated both genetic diversity pathogen evasion. Previously, we discovered single nucleotide polymorphism (rs2869462) associated absolute abundance of CXCL10, pro-inflammatory T-cell chemokine. Here, report that levels CXCL10 change during C....
Leishmaniasis is a neglected tropical disease with diverse outcomes ranging from self-healing lesions, to progressive non-healing metastatic spread and destruction of mucous membranes. Although resolution cutaneous leishmaniasis classic example type-1 immunity leading an excess related inflammation can contribute immunopathology spread. Leishmania genetic diversity variation in polarization robustness the immune response through differences both pathogen sensing by host evasion parasite. In...
Human genetic diversity can have profound effects on health outcomes upon exposure to infectious agents. For infections with
Abstract Clearance of intracellular pathogens, such as Leishmania (L.) major , depends on a well-regulated adaptive T cell response. Here we describe pathogen-encoded mechanism to alter recruitment by suppressing CXCL10, chemokine that recruits CD4+ and CD8+ cells signaling through the CXCR3 receptor. L. suppresses CXCL10 virulence factor protease, glycoprotein-63 (gp63). GP63 cleaves after amino acid A81, impairing T-cell chemotaxis in vitro. from either extracellular promastigotes or...