There have been major concerns that the nephrotoxicity of commercial formulations Roundup herbicide is due to active ingredient glyphosate. We therefore investigated and compared mechanisms underlining glyphosate alone in rat. Fifty-six adult male rats randomized into 7 groups 8 per group were exposed formulation daily by gavage at 3.6, 50.4, 248.4 mg/kg body weight (bw) concentrations for 12 weeks with distilled water administered control group. Kidney biomarker (serum urea creatinine,...

While the impact of glyphosate-based herbicides (GBHs) on earthworms has been studied, little is known about their effects earthworm gut microbiome. This study investigated a GBH microbial communities three species (Alma millsoni, Eudrilus eugeniae and Libyodrilus violaceus). Earthworm accommodated in soil were sprayed with 115.49 mL/m² Roundup® Alphée or water. Gut microbiome composition was analysed using 16S rRNA Bacterial Tag–Encoded FLX Amplicon Pyrosequencing (bTEFAP) at 8th week...

Gasoline fume has been considered a major air pollutant affecting the heart, lungs, brain, liver and kidneys. Therefore, this study aims at investigating effect of inhalation exposure to gasoline on some endogenic stress hormones oxidative enzymes albino rats. Forty adult male rats were randomly assigned five experimental treatments (T) with eight per treatment (T1, T2, T3, T4 T5). The control treatment, T1 was housed in section animal house free from fumes while T5 exposed chambers for one,...

The occurrence of conflicting reports on the improvement male reproductive function among humans fed diet containing seed Mucuna pruriens (MP) have raised a major concern in Nigeria. We assessed effect MP powder 32 adult albino rats randomized to 4 groups 8 each for weeks. Group 1 (control) was given standard rat chow while 2, 3 and were diets at 0.75 g, 1.5 g 2.25 respectively. Serum level follicle stimulating hormone, testosterone, luteinizing oxidative stress markers testis, epididymal...

No recognised study has been conducted to monitor atrazine residue in drinking water from rural agricultural areas Nigeria and its potential health implications. In this ecotoxicological study, we monitored 69 hand-dug wells (HDW), 40 boreholes (BH) 4 major streams all the 6 communities (Ago-Iwoye, Ijebu-Igbo, Oru, Awa, Ilaporu Mamu) Ijebu North Local Government Area, Southwest Nigeria. Values of obtained were further used evaluate non-carcinogenic risk associated with ingestion dermal...

Over 100 million people in Africa are affected by protein malnutrition because they cannot afford conventional animal protein. The light yellowish-brown cricket (Acheta domesticus) is one of the species preferred for mass rearing. study was aimed at assessing safety house meal human and animals’ consumption Nigeria. Four crickets were collected from wild reared Olabisi Onabanjo University, Ago-Iwoye, Ogun State, Nigeria to produce several generations. Samples adult nymph obtained stock...

Toxic effects of gasoline fumes have been reported, but evidence its hepatotoxicity and genotoxicity are rare. Therefore, this study assesses on forty Albino rats randomly assigned to five experimental treatments (T) with eight per treatment (T1, T2, T3, T4 T5). T1(Control) was housed in a section animal house free from while T5 were exposed exposure chambers for one, three, nine hours daily respectively twelve weeks. Serum alanine aminotransferase (ALT), aspartate (AST), alkaline...

There are no available data on the level of atrazine in drinking water from rural agricultural areas Nigeria and its potential health implications. Here, we measured residue 69 hand-dug wells (HDW), 40 boreholes (BH), four major streams six communities (Ago-Iwoye, Ijebu-Igbo, Oru, Awa, Ilaporu, Mamu) Ijebu North Local Government Area, Southwest Nigeria. Values obtained were further used for evaluation non-carcinogenic risk associated with ingestion dermal contact adults children as well...

<p>The use of Glutathione-S-transferase (GST) activities in earthworm tissue as tool for assessment heavy metal pollution abattoir soils was evaluated this study. Five (5) replicates each species (<em>Libyodrilus violaceous</em>, <em>Eudrilus eugeniae</em> and <em>Alma millsoni</em>), soil rumen waste samples were collected from three (3) sites (Lafenwa, Gbonogun Madojutimi abattoirs) a control site located within Federal University Agriculture...

The mechanism underlying the reported hepatotoxicity of gasoline fumes in experimental studies still remains unclear. In this study, we present insights into 72 male albino rats. rats were randomized six groups. Group I (control) was exposed to distilled water while groups II, III, IV, V and VI daily for 1, 3, 5, 7 9 hours respectively 10 weeks. Serum hepatic oxidative stress markers, activity mixed function oxygenase (MFO) membrane-bound ATPase enzymes liver as well histopathological...

Exposures to Artificial Light at Night (ALAN) is on the increase with resultant varied physiological impact related light spectrum via non-visual pathway. This study examined effects of various spectra ALAN Testosterone (Te), Progesterone (Pr) and Estradiol (Es) in rats exposed Blue (BL), Green (GL), Yellow (YL), Red (RL), White (WL) Darkness (DD) wave-lengths while Ambient (CL) served as control. Dams their post-natal day 1 pups were housed cages wavelengths for 12 hours: (6:00pm–6:00am)...

The search for medicinal plants with novel properties therapeutical potentials is a continuum. preliminary phytochemical analysis, antimicrobial and proximate contents of Costus spectabilis leaf root harvested from different soil types were studied following standard protocols. ethyl ethanoate extracts assayed against six microbial cultures Staphylococcus aureus (ATCC 29523), Pseudomonas aeruginosa 27853), Bacillus subtilis 6633), Aspergillus niger, Candida albicans, clavatus using the agar...

A total of 286 individuals from 3 selected communities (Areedi-Aje, Ipakodo/Ojokodo, and Ijebu-Igbo) Ijebu-North, southwestern Nigeria were examined for Loa loa microfilaremia using finger prick blood smear, between December 2008 March 2009. Rapid assessment procedure loiasis (RAPLOA) was used to obtain information, 187 Ijebu-Igbo residents, on adverse reactions experienced retrospective treatments with ivermectin history eye worm. Only 33.9% the respondents reported having had a worm while...

There is an increasing overdependence and use of atrazine herbicide for the control pre-and post-emergence broad leaf weeds on maize farms in rural agricultural communities Nigeria. We carried out a survey residue 69 hand-dug wells (HDW), 40 boreholes (BH) 4 streams from all 6 (Awa, Mamu, Ijebu-Igbo, Ago-Iwoye, Oru Ilaporu) Ijebu North Local Government Area, Southwest The effect highest concentration detected water each hypothalamic-pituitary-adrenal (HPA) axis albino rats was investigated....

Abstract Background Hunteria umbellatta (HU) is a predominant plant with share of therapeutic properties against various human diseases no scientific report its in vitro ethno-toxicology coupled molecular implication the literature. This study, therefore, evaluated toxicological activity and quantification expression specific swarming gene, lateral flagellar (Laf A) adhesion gene (ExsE) Vibrio parahaemolyticus (VP) treated methanol seed stem extracts HU at 500, 250, 125, 62.5, 31.25, 15.625,...