A5100398580- Metal-Catalyzed Oxygenation Mechanisms
- Metal-Organic Frameworks: Synthesis and Applications
- Porphyrin Metabolism and Disorders
- Microbial bioremediation and biosurfactants
- Heme Oxygenase-1 and Carbon Monoxide
- Asymmetric Hydrogenation and Catalysis
- Microbial metabolism and enzyme function
- Magnetism in coordination complexes
- Amino Acid Enzymes and Metabolism
- Hemoglobin structure and function
- Advanced Sensor and Energy Harvesting Materials
- Titanium Alloys Microstructure and Properties
- Catalytic Processes in Materials Science
- Nuclear Materials and Properties
- Microbial Natural Products and Biosynthesis
- Fluorine in Organic Chemistry
- Metal complexes synthesis and properties
- Carbon Nanotubes in Composites
- Polyoxometalates: Synthesis and Applications
- Additive Manufacturing Materials and Processes
- Enzyme Structure and Function
- Aerogels and thermal insulation
- Catalysis for Biomass Conversion
- Surface Chemistry and Catalysis
- Thermal properties of materials
Dalian Polytechnic University
2024
University of Georgia
2023-2024
East China University of Science and Technology
2023-2024
China General Nuclear Power Corporation (China)
2022-2024
Wuhan University
2024
The University of Texas at San Antonio
2016-2023
Beijing Institute of Technology
2023
Beijing University of Technology
2023
Shanxi Normal University
2022
China Academy of Launch Vehicle Technology
2022
UiO-66-encapsulated nanopalladium (Pd@UiO-66) catalysts were used as highly efficient and stable for continuous catalytic upgrading of ethanol to n-butanol. The best Pd@UiO-66 catalyst exhibited 49.8% conversion, 48.6% selectivity toward n-butanol, thereby 24.2% n-butanol yield at relatively low temperature (523 K) pressure (2 MPa) during a 200 h long-term evaluation. high activity are primarily ascribed the close synergy dispersed Pd nanoparticles coordinatively unsaturated Zr sites on Zr6...
Cysteamine dioxygenase (ADO) has been reported to exhibit two distinct biological functions with a nonheme iron center. It catalyzes oxidation of both cysteamine in sulfur metabolism and N-terminal cysteine-containing proteins or peptides, such as regulator G protein signaling 5 (RGS5). thereby preserves oxygen homeostasis variety physiological processes. However, little is known about its catalytic center how it interacts these types primary substrates addition O2. Here, using electron...
Abstract Correction fuses have been widely used in the information battlefield recent years due to their advantages of low cost, convenient replacement, and high cost-effectiveness. The rotation projectile equipped with a correction fuse has complex angular motion its rotational stability characteristics during correction. In response more complicated situations such as marine weather, ocean currents, tides, etc., maritime combat environments, capability is limited, atmospheric environment...
We investigated the segmental mobility distribution at poly(methyl methacrylate) film surface within depth of 9.0 nm, by measuring reorganization fluorinated tracer-labeled PMMA using three different surface-sensitive techniques with various analytical capabilities, including contact angle measurements, sum frequency generation (SFG) vibrational spectra and angle-resolved X-ray photoelectron spectroscopy (XPS). The onset temperature chain end (Tonset) depths was identified is shown to depend...
Cysteamine dioxygenase (ADO) plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis humans by oxidizing the sulfur of cysteamine N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as cosubstrate. However, only that processes both small-molecule protein substrates, how ADO handles diverse substrates disparate sizes achieve various reactions is not understood. The knowledge gap mainly due three-dimensional structure being solved,...
The P450 enzyme CYP121 from
Abstract Cysteamine dioxygenase (ADO) is a thiol whose study has been stagnated by the ambiguity as to whether or not it possesses an anticipated protein‐derived cofactor. Reported herein discovery and elucidation of Cys‐Tyr cofactor in human ADO, crosslinked between Cys220 Tyr222 through thioether (C−S) bond. By genetically incorporating unnatural amino acid, 3,5‐difluoro‐tyrosine (F 2 ‐Tyr), specifically into autocatalytic oxidative carbon–fluorine bond activation fluoride release were...
Two new sets of UiO-Zr metal–organic framework (MOF) bearing mixed linkers BDC-(SCH3)2 and BDC-(SOCH3)2 that have different band gaps edges were prepared through post oxidation direct methods, namely, UiO-66-(SCH3)2-xh (x = 4, 9, 12 hours) UiO-66-(SOCH3)x(SCH3)2–x 0, 0.4, 0.6, 2), respectively. These composites with stoichiometric components fully characterized via proton nuclear magnetic resonance (1H NMR) spectroscopy, powder X-ray diffraction (PXRD), transmission electron microscopy...
Organic single crystal/polymer hybrid actuators that can be applied in extreme conditions such as polar regions and space are extremely important rare. Herein, we report an simple but efficient strategy to fabricate organic crystalline materials with low-temperature, humidity actuation, waveguide properties. First, needle-like crystals composed of 10-(trifluoromethyl)anthracene-9-carbonitrile (TFMAC) exhibited excellent elastic properties the temperature range 77–423 K. Second, prepared a by...
CYP121 is a P450 enzyme from Mycobacterium tuberculosis that catalyzes C–C coupling reaction between the two aromatic rings on its native substrate cyclo(l-Tyr-l-Tyr) (cYY) to form mycocyclosin, necessary product for cell survival. Unlike typical enzymes hydroxylation, believed behave like peroxidase and conduct radical-mediated bond formation. Here, we probe whether phenolic hydrogen of site postulated atom abstraction radical We synthesized singly O-methylated analogue, cYF-4-OMe,...
LmbB2 is a peroxygenase-like enzyme that hydroxylates l-tyrosine to l-3,4-dihydroxyphenylalanine (DOPA) in the presence of hydrogen peroxide. However, its heme cofactor ligated by proximal histidine, not cysteine. We show can oxidize analogues with ring-deactivated substituents such as 3-nitro-, 3-fluoro-, 3-chloro-, and 3-iodo-l-tyrosine. also found 4-hydroxyl group substrate essential for reacting heme-based oxidant activating aromatic C–H bond. The most interesting observation this study...
The synthesis of quinolinic acid from tryptophan is a critical step in the de novo biosynthesis nicotinamide adenine dinucleotide (NAD
The heme-dependent l-tyrosine hydroxylases (TyrHs) in natural product biosynthesis constitute a new enzyme family contrast to the nonheme iron enzymes for DOPA production. A representative TyrH exhibits dual reactivity of C-H and C-F bond cleavage when challenged with 3-fluoro-l-tyrosine (3-F-Tyr) as substrate. However, little is known about how mediates two distinct reactions. Herein, from thermophilic bacterium Streptomyces sclerotialus (SsTyrH) was functionally structurally characterized....
Rufomycins constitute a class of cyclic heptapeptides isolated from actinomycetes. They are secondary metabolites that show promising treatment against Mycobacterium tuberculosis infections by inhibiting novel drug target. Several nonproteinogenic amino acids integrated into rufomycins, including conserved 3-nitro-tyrosine. RufO, cytochrome P450 (CYP)-like enzyme, was proposed to catalyze the formation 3-nitro-tyrosine in presence O2 and NO. To define its biological function, interaction...
Material and structure made by additive manufacturing (AM) have received much attention lately due to their flexibility ability customize complex structures. This study first implements multiple objective topology optimization simulations based on a projectile perforation model, new topologic is obtained. Then two types of 316L stainless steel projectiles (the solid the topology) are printed in selective laser melt (SLM) machine evaluate penetration performance ballistic test. The experiment...
Abstract A new supramolecular nanocage, VMOP‐ 31 , based on polyoxovanadate as the molecular building block, has been designed and synthesized under solvothermal conditions. The structure of was determined by single‐crystal powder X‐ray diffraction, FTIR spectroscopy, UV/Vis spectrophotometry, thermogravimetric analysis. nanocage exhibits octahedral geometry is constructed six {V 5 O 9 Cl(COO) 4 } at vertices eight TATB (H 3 TATB=4,4′,4′′‐( s ‐triazine‐2,4,6‐triyl)tribenzoic acid) ligands...
Two histidine-ligated heme-dependent monooxygenase proteins, TyrH and SfmD, have recently been found to resemble enzymes from the dioxygenase superfamily currently named after tryptophan 2,3-dioxygenase (TDO), that is, TDO superfamily. These latest findings prompted us revisit structure function of The in this share a similar core architecture heme. Their primary functions are promote O-atom transfer an aromatic metabolite. indoleamine (IDO), founding members, dioxygenation through two-step...