A5028258130- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- SARS-CoV-2 detection and testing
- Sodium Intake and Health
- Respiratory viral infections research
- Chemokine receptors and signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Hepatitis B Virus Studies
- Immune cells in cancer
- Animal Virus Infections Studies
- Genetics and Neurodevelopmental Disorders
- SARS-CoV-2 and COVID-19 Research
- Neonatal Respiratory Health Research
Instituto de Investigaciones Biomédicas en Retrovirus y Sida
2022-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2022-2023
University of Buenos Aires
2022-2023
Joslin Diabetes Center
2023
Harvard University
2023
Monocytes can differentiate into macrophages (Mo-Macs) or dendritic cells (Mo-DCs). The cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the differentiation of monocytes Mo-Macs, while combination GM-CSF/interleukin (IL)-4 is widely used to generate Mo-DCs for clinical applications and study human DC biology. Here, we report that pharmacological inhibition nuclear receptor peroxisome proliferator-activated gamma (PPARγ) in presence GM-CSF absence IL-4 monocyte...
There is a paucity of reports on the characteristics severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in infants, because most studies have grouped infants with older children. We analyzed viral loads 45318 SARS-CoV-2-positive nasopharyngeal swab samples obtained Buenos Aires, Argentina. Infants younger than 6 months presented higher any other age group. Children showed significantly lower loads, similar to those founds adults. This observation raises new questions...
High salt (NaCl) concentrations are found in a number of tissues under physiological and pathological conditions. Here, we analyzed the effects induced by high on function human neutrophils. The culture neutrophils medium supplemented with (50 mM NaCl) for short periods (30-120 min) inhibited ability conventional agonists to induce production IL-8 activation respiratory burst. By contrast, exposure longer (6-18 h) resulted revealed levels IL-8, burst, marked synergistic effect TNF-α LPS....
Type 2 diabetes is partly characterized by decreased β-cell mass and function which have been linked to cellular senescence. Despite a low basal proliferative rate of adult β-cells, they can respond growth stimuli, but this capacity decreases with age correlates increased expression senescence effector, p16Ink4a. We hypothesized that selective deletion p16Ink4a-positive cells would enhance the remaining β-cells due elimination local senescence-associated secretory phenotype (SASP). aimed...
Solid organ transplant recipients (SOTR) commonly develop an unsatisfactory humoral response to vaccines compared immunocompetent individuals (IC). We have previously evaluated the in liver (LTR) who received two-dose against SARS-CoV-2 and reported that 38 % of LTR did not produce anti-Spike antibodies. Thus, we set out evaluate after third dose vaccines. For this purpose, samples from a cohort 81 27 IC were extracted between 21 90 days dose. Serology for IgG antibodies neutralizing Wuhan,...