A5070668922- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Mosquito-borne diseases and control
- Respiratory viral infections research
- Diabetes and associated disorders
- Animal Virus Infections Studies
- Hepatitis B Virus Studies
- Insect symbiosis and bacterial influences
- Inflammatory Biomarkers in Disease Prognosis
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 detection and testing
- Neonatal Respiratory Health Research
- Higher Education and Sustainability
- Education and Teacher Training
- COVID-19 epidemiological studies
- HIV-related health complications and treatments
- Viral Infections and Immunology Research
- HIV Research and Treatment
- Viral Infections and Vectors
- Hepatitis C virus research
Consejo Nacional de Investigaciones Científicas y Técnicas
2021-2022
University of Buenos Aires
2021-2022
Instituto de Investigaciones Biomédicas en Retrovirus y Sida
2021-2022
Hospital Clínico Universitario de Valencia
1992
Heterologous vaccination against coronavirus disease 2019 (COVID-19) provides a rational strategy to rapidly increase coverage in many regions of the world. Although data regarding messenger RNA (mRNA) and ChAdOx1 vaccine combinations are available, there is limited information about combination these platforms with other vaccines widely used developing countries, such as BBIBP-CorV Sputnik V. Here, we assess immunogenicity reactogenicity 15 1,314 participants. We evaluate immunoglobulin G...
Abstract Severe coronavirus disease 2019 (COVID-19) is associated with an overactive inflammatory response mediated by macrophages. Here, we analyzed the phenotype and function of neutrophils in patients COVID-19. We found that from severe COVID-19 express high levels CD11b CD66b, spontaneously produce CXCL8 CCL2, show a strong association platelets. Production correlated plasma concentrations lactate dehydrogenase D-dimer. Whole blood assays revealed clear immunoglobulin G (IgG) immune...
There is a paucity of reports on the characteristics severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in infants, because most studies have grouped infants with older children. We analyzed viral loads 45318 SARS-CoV-2-positive nasopharyngeal swab samples obtained Buenos Aires, Argentina. Infants younger than 6 months presented higher any other age group. Children showed significantly lower loads, similar to those founds adults. This observation raises new questions...
Summary Severe COVID‐19 is associated with a systemic inflammatory response and progressive CD4 + T‐cell lymphopenia dysfunction. We evaluated whether platelets might contribute to dysfunction in COVID‐19. observed high frequency of T cell–platelet aggregates inpatients that inversely correlated lymphocyte counts. Platelets from but not healthy donors (HD) inhibited the upregulation CD25 expression tumour necrosis factor (TNF)‐α production by cells. In addition, interferon (IFN)‐γ was...
Shortages of component two Sputnik V vaccine (rAd5) are delaying the possibility achieving full immunisation. The immunogenic response associated with use alternative schemes to complete scheme was not explored.We did non-inferiority randomized clinical trials outcomes measures blinded investigators on adults aged 21-65 years, vaccinated a single dose rAd26 ≥ 30 days before screening and no history SARS-CoV-2. Participants were assigned (1:1:1:1:1) receive either rAd5; ChAdOx1; rAd26;...
Zika virus (ZIKV) is a flavivirus transmitted by mosquitoes of the genus Aedes, but unlike other flaviviruses, ZIKV can be sexually vaginal intercourse. The healthy pH ranges from 4.0 to 6.0, reaching values 6.0-7.0 after semen deposition. Here, we report that low extracellular (range 6.2-6.6) dramatically increase infection on cell lines different origin including some derived female genital tract and monocyte-derived macrophages. Furthermore, significantly increased human ectocervix...
Abstract Background Monocyte activation is a driver of inflammation in the course chronic HIV infection. Prostaglandin E2 (PGE2) known to mediate anti-inflammatory effects, notably inhibition tumor necrosis factor-α (TNF-α) production by monocytes. We aim investigate effects PGE2 on monocytes infection and mechanisms through which modulates their inflammatory signature. Methods recruited group people with (PWH) matched healthy uninfected persons. compared plasma levels PGE2, monocyte...