A5107517189- Pharmacology and Obesity Treatment
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Eicosanoids and Hypertension Pharmacology
- Pain Mechanisms and Treatments
- Diet and metabolism studies
- Stress Responses and Cortisol
- Lanthanide and Transition Metal Complexes
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience and Neuropharmacology Research
- Wound Healing and Treatments
- Fatty Acid Research and Health
- Metal complexes synthesis and properties
- Protein Interaction Studies and Fluorescence Analysis
- Alcoholism and Thiamine Deficiency
- Pediatric Pain Management Techniques
- Magnesium in Health and Disease
- Oral and gingival health research
- Surgical Sutures and Adhesives
- Drug Solubulity and Delivery Systems
- Pharmacological Effects and Toxicity Studies
- SARS-CoV-2 and COVID-19 Research
- Vanadium and Halogenation Chemistry
- Cyclopropane Reaction Mechanisms
- Biochemical effects in animals
National University of La Rioja
2010-2025
Czech Academy of Sciences, Institute of Biotechnology
2025
Ministerio de Salud
2022
Universidad de La Rioja
2022
Instituto de Física La Plata
2019
Consejo Nacional de Investigaciones Científicas y Técnicas
2019
Universidad Nacional de La Plata
2019
Instituto de Investigaciones en Ciencias de la Salud
2010-2012
Heterologous vaccination against coronavirus disease 2019 (COVID-19) provides a rational strategy to rapidly increase coverage in many regions of the world. Although data regarding messenger RNA (mRNA) and ChAdOx1 vaccine combinations are available, there is limited information about combination these platforms with other vaccines widely used developing countries, such as BBIBP-CorV Sputnik V. Here, we assess immunogenicity reactogenicity 15 1,314 participants. We evaluate immunoglobulin G...
Abstract Objectives Current pharmacological treatments for neuropathic pain have limited efficacy and may cause undesirable side effects. Cannabidiol (CBD)-enriched cannabis oil omega-3 fatty acids (ω-3) emerged as potential therapeutic options due to their analgesic anti-inflammatory properties. This study aimed assess the antinociceptive effects of combining CBD-enriched ω-3 in rat models acute pain. Methods Using hot plate test chronic constriction injury (CCI) model pain, thermal...
Abstract Objectives Recent evidence associates omega-3 fatty acids (O3) with pain reduction. The aim of this work was to evaluate the antinociceptive effect O3, either alone or in combination morphine after acute and chronic administration rats. As well, a new pharmaceutical mixture that allows concomitant O3 as an oral solution developed. Methods Animals were fed on control experimental diet supplemented O3. They subjected hot-plate test assess analgesic tolerance morphine. open-field...
Abstract Objective The aim of this work was to assess the preventive effect an eicosapentaenoic acid/docosahexaenoic acid-concentrate fish oil on neuropathic pain development and regenerative features sciatic nerve in rats. Methods In present study, rats with chronic constriction injury (CCI) sham-operated ones received enriched omega-3 fatty acids (0.36 or 0.72 g/kg per day, oral) saline solution for 21 days, thermal hyperalgesia mechanical allodynia being assessed before 3, 7, 14 days...
Abstract The development of new treatments capable controlling infections and pain related to burns continues be a challenge. Antimicrobials are necessary tools, but these can cytotoxic for regenerating cells. In this study, antibiotic-anesthetic (AA) smart systems obtained by ionic complexation polyelectrolytes with ciprofloxacin lidocaine were as films hydrogels. Ionic sodium alginate hyaluronate decreased cytotoxicity above 70% in primary culture isolated fibroblasts (p < 0.05)....
The antidepressant effect of simple Zn(II) salts has been proved in several animal models depression. In this study, a coordination metal complex having sulfur containing ligand is tested as for the first time. Forced swimming test method on male Wistar rats shows decrease immobility and an increase behavior after treatment with [Zn(S-Met)2] (S-Met=S-methyl-l-cysteine) being more effective remarkable than ZnCl2. thiobarbituric acid pyranine consumption (hydroxyl peroxyl radicals,...
The treatment of acute and chronic severe pain remains a common major challenge faced by clinicians working with the general population, even after application recent advances to treatments, there may still continue be manifestations adverse effects. Chronic affects personal social life patient, often also their families. In some cases, an patient continues experience pain, which can result diseases such as cancer. Morphine is recommended first choice opioid in moderate pain. However,...
The treatment of acute and chronic severe pain remains a common major challenge faced by clinicians working with the general population, even after application recent advances to treatments, there may still continue be manifestations adverse effects.