Laura Pala

ORCID: 0000-0003-0386-8457
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About
Contact & Profiles
Research Areas
  • Diabetes Treatment and Management
  • Diabetes Management and Research
  • Pancreatic function and diabetes
  • Metabolism, Diabetes, and Cancer
  • Diabetes and associated disorders
  • Pharmacology and Obesity Treatment
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Eating Disorders and Behaviors
  • Diet and metabolism studies
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Peptidase Inhibition and Analysis
  • Adipokines, Inflammation, and Metabolic Diseases
  • Growth Hormone and Insulin-like Growth Factors
  • Obesity, Physical Activity, Diet
  • Neuropeptides and Animal Physiology
  • Cardiovascular Function and Risk Factors
  • Cancer, Hypoxia, and Metabolism
  • Lipid metabolism and disorders
  • Liver Disease Diagnosis and Treatment
  • Atherosclerosis and Cardiovascular Diseases
  • Diabetes Management and Education
  • Cardiac Imaging and Diagnostics
  • Oral microbiology and periodontitis research
  • Health and Lifestyle Studies
  • Blood Pressure and Hypertension Studies

Azienda Ospedaliero-Universitaria Careggi
2014-2023

University of Florence
2008-2022

Endocrinology Research Center
2013

Hypoglycemic treatments could modulate the risk for fractures in many ways. Most studies have not explored effect on incidence of bone individual oral hypoglycemic agents, rather all as a whole. The aim this case-control study, nested within retrospective cohort, is assessment associated with exposure to insulin or different agents.A study cohort 1,945 diabetic outpatients follow-up 4.1 +/- 2.3 years was performed, comparing 83 case subjects and 249 control matched age, sex, duration...

10.2337/dc07-1736 article EN Diabetes Care 2008-01-28

OBJECTIVE Recent epidemiological studies suggested that some insulin analogues could be associated with increased risk of cancer. The present study is aimed at assessing the long-term association different cancer incidence. RESEARCH DESIGN AND METHODS A nested case-control dataset was generated from cohort (n = 1,340 insulin-treated diabetic outpatients) by sampling control subjects sets. For each case subject, (up to five) were chosen randomly those members who are for same follow-up time...

10.2337/dc10-0476 article EN cc-by-nc-nd Diabetes Care 2010-06-14

Obesity represents the second preventable mortality cause worldwide, and is very often associated with type 2 Diabetes Mellitus (T2DM). The first line treatment lifestyle modification to weight-loss, but for those who fail achieve goal or have difficulty in maintaining achieved results, pharmacological needed. Few drugs are available today, because of their side effects.We aim review actual management obese patients, highlighting differences between Food Drug Administration - European...

10.2174/0929867326666190124121725 article EN Current Medicinal Chemistry 2019-01-25

Background: The International Diabetes Federation (IDF) proposed to modify the diagnostic criteria for metabolic syndrome (MS) previously issued by National Cholesterol Education Program (NCEP). Aim of present investigation is compare predictive value diabetes NCEP and IDF definitions MS in a large sample predominantly Caucasian subjects. Methods: A prospective observational study was performed on cohort (n = 3096) enrolled diabetes‐screening programme, FIrenze‐Bagno Ripoli study. All...

10.1111/j.1463-1326.2007.00724.x article EN Diabetes Obesity and Metabolism 2007-04-05

Diabet. Med. 27, 691–695 (2010) Abstract Aim The reduced levels of glucagon‐like peptide 1 (GLP‐1) after an oral glucose load in Type 2 diabetic patients could be dependent either on a synthesis or increased degradation; but GLP‐1 and dipeptidyl peptidase IV (DPP‐IV) during tolerance test (OGTT) have not been studied together. aim the present study was to investigate DPP‐IV OGTT with different degrees tolerance. Methods Fifty six subjects (34 female, 22 male) matched for sex, age, body mass...

10.1111/j.1464-5491.2010.03010.x article EN Diabetic Medicine 2010-05-20

Background and Aims . The secretion of several adipocytokines, such as adiponectin, retinol-binding protein 4 (RBP4), adipocyte fatty acid binding (aFABP), visfatin, is altered in subjects with abdominal adiposity; these endocrine alterations could contribute to increased cardiovascular risk. aim the study was assess relationship among RBP4, aFABP, incident disease. Methods Results A case-control study, nested within a prospective cohort, on 2945 enrolled for diabetes screening program...

10.1155/2012/253428 article EN cc-by Journal of Nutrition and Metabolism 2011-08-22

Cardiovascular disease (CVD) is prevalent in women after menopause, which may be associated with obesity, insulin resistance and metaflammation. Despite the recognized role of immunological mechanisms vascular remodeling, dendritic cells (DCs) still unclear. The aim was to characterize monocyte-derived DCs (Mo-DC) post-menopausal patients type 2 diabetes (T2DM) obese woman, without clinical manifestations atherosclerosis.

10.1016/j.diabres.2020.108528 article EN cc-by Diabetes Research and Clinical Practice 2020-11-04

To investigate the efficacy of a combination continuous glucose monitoring (CGM) and subcutaneous insulin infusion (CSII) versus an optimized degludec-based multiple daily injections (MDI) regimen + self-monitoring blood (SMBG) in people with type 1 diabetes regard to optimizing control.The trial included 28 individuals who underwent 4-week run-in phase, were then randomized 1:1 to: (a) CSII CGM followed by MDI SMBG or (b) basal-bolus CGM.In patients → arm, significant reduction glycated...

10.1111/dom.14028 article EN Diabetes Obesity and Metabolism 2020-03-13
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