A5032669867- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Transplantation: Methods and Outcomes
- Congenital Heart Disease Studies
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiovascular Issues in Pregnancy
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiac Imaging and Diagnostics
- Elasticity and Material Modeling
- Cardiac tumors and thrombi
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Coronary Artery Anomalies
- MicroRNA in disease regulation
- Organ Transplantation Techniques and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Acute Lymphoblastic Leukemia research
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2022
Nicolaus Copernicus University
2020
NorthEast Regional Epilepsy Group
2018
Fondazione IRCCS Istituto Nazionale dei Tumori
2016-2017
Mylan (Switzerland)
2017
Sterling Hospitals
2017
University of Udine
2017
N.N. Alexandrov National Cancer Centre
2017
Barro Colorado Island
2015
Rationale: Aging represents a major risk factor for coronary artery disease and aortic aneurysm formation. MicroRNAs (miRs) have emerged as key regulators of biological processes, but their role in age-associated vascular pathologies is unknown. Objective: We aim to identify miRs the vasculature that are regulated by age play age-induced pathologies. Methods Results: Expression profiling tissue young versus old mice identified several miRs. Among significantly miRs, increased expression...
Purpose: We describe an approach for anticoagulation and transfusions in veno-venous–extracorporeal membrane oxygenation (VV-ECMO), evaluating factors associated with higher transfusion requirements, their impact on mortality. Methods: Observational study consecutive adults supported VV-ECMO acute respiratory distress syndrome (ARDS). targeted activated partial thromboplastin time of 40 to 50 seconds a hematocrit 24% 30%. Univariate multiple analyses were done evaluate requirements the...
Cardiac progenitors, such as cardiospheres and cardiosphere-derived cells, represent an attractive cell source for cardiac regeneration. The PIWI-interacting RNAs, piRNAs, are intriguing class of small non-coding implicated in the regulation epigenetic state, maintenance genomic integrity stem functions. Although RNAs exploiting field cardiovascular research, piRNA signatures progenitors has not been evaluated yet.We profiled, through microarrays, 15,311 piRNAs expressed cardiospheres, cells...
To evaluate incidence, risk factors, and outcomes of postoperative neurological complications in patients undergoing cardiac surgery.A total 2121 underwent surgery between August, 2008 December, 2013; 91/2121 (4.3%) brain computed tomography (70/91, 77%) or magnetic resonance imaging (21/91, 23%) scan because major stroke (37/2121, 1.7%) a spectrum transient episodes as well ischemic attacks delirium /psychosis/seizures (54/2121, 2.5%). The mean age was 65.3 ± 12.1 years 60 (65.9%) were...
During veno-arterial extracorporeal membrane oxygenation (VA-ECMO), the increase of left ventricular (LV) afterload can potentially LV stress, exacerbate myocardial ischemia and delay recovery from cardiogenic shock (CS). Several strategies unloading have been proposed. Systematic review meta-analysis in accordance with Preferred Reporting Items for Reviews Meta-Analyses (PRISMA) statement included adult patients studies published between January 2000 March 2019. The search was conducted...
Objectives Primary graft failure (PGF) after heart transplantation is a detrimental complication, and carries high morbidity mortality. The aim of this study was to analyze the results our multidisciplinary approach in supporting patients affected with PGF transplantation. Methods Out 114 consecutive receiving orthotopic between January 2006 July 2013, 18 (15.7%) developed requiring veno-arterial extracorporeal membrane oxygenator (VA-ECMO) support. Fourteen were male mean age 49 ± 11 years....
BacKgroUND: acute respiratory distress syndrome (arDs) survivors are affected with long-term physical/mental impairments, improvements limited mostly to the first year after intensive care (ICU) discharge.Furthermore, caregivers of icU patients exhibit psychological problems family-member recovery.We evaluated physical and mental recovery arDs treated veno-venous extracorporeal membrane oxygenation (VV-ecMo), impact on their caregivers.MetHoDs: single-center prospective evaluation a...
An ascending thoracic aortic aneurysm (ATAA) is a heterogeneous disease showing different patterns of dilatation and valve morphologies, each with distinct clinical course. This study aimed to explore the morphology associations between shape function in population ATAA, while further assessing novel risk models surgery not based on size. Shape variability n = 106 patients ATAA morphologies (i.e., bicuspid versus tricuspid valve) was estimated by statistical analysis (SSA) compute mean its...